Peringatan Keamanan

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

Salicylic acid

DB00936

small molecule approved investigational vet_approved

Deskripsi

A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.

Struktur Molekul 2D

Berat 138.1207
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi The volume of distribution is about 170 mL/kg of body weight.[L32363]
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Salicylic acid is extensively metabolized.L32363

Rute Eliminasi

About 10% is excreted unchanged in the urine.L32363

Interaksi Obat

1675 Data
Amlodipine The metabolism of Salicylic acid can be decreased when combined with Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Salicylic acid.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Salicylic acid.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Salicylic acid.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Salicylic acid.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Salicylic acid.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Salicylic acid.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Salicylic acid.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Salicylic acid.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Salicylic acid.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Salicylic acid.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Salicylic acid.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Salicylic acid.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Salicylic acid.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Salicylic acid.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Salicylic acid.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Salicylic acid.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Salicylic acid.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Salicylic acid.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Salicylic acid.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Salicylic acid.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Salicylic acid.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Salicylic acid.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Salicylic acid.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Salicylic acid.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Salicylic acid.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Salicylic acid.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Salicylic acid.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Salicylic acid.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Salicylic acid.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Salicylic acid.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Salicylic acid.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Salicylic acid.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Salicylic acid.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Salicylic acid.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Salicylic acid.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Salicylic acid.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Salicylic acid.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Salicylic acid.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Salicylic acid.
Diethylpropion The risk or severity of hypertension can be increased when Salicylic acid is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Salicylic acid is combined with Naratriptan.
Frovatriptan The risk or severity of hypertension can be increased when Salicylic acid is combined with Frovatriptan.
Ergoloid mesylate The risk or severity of hypertension can be increased when Salicylic acid is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Salicylic acid is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Salicylic acid is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Salicylic acid is combined with Dutasteride.
Pergolide The risk or severity of hypertension can be increased when Salicylic acid is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Salicylic acid is combined with Desflurane.
Finasteride The risk or severity of hypertension can be increased when Salicylic acid is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Salicylic acid is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Salicylic acid is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Salicylic acid is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Salicylic acid is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Salicylic acid is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Salicylic acid is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Salicylic acid is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Salicylic acid is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Salicylic acid is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Salicylic acid is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Salicylic acid is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Salicylic acid is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Salicylic acid is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Salicylic acid is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Salicylic acid is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Salicylic acid is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Salicylic acid is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Salicylic acid is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Salicylic acid is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Salicylic acid is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Salicylic acid is combined with Indacaterol.
Rotigotine The risk or severity of hypertension can be increased when Salicylic acid is combined with Rotigotine.
Amibegron The risk or severity of hypertension can be increased when Salicylic acid is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Salicylic acid is combined with Naluzotan.
Cariprazine The risk or severity of hypertension can be increased when Salicylic acid is combined with Cariprazine.
Mianserin The risk or severity of hypertension can be increased when Salicylic acid is combined with Mianserin.
Pizotifen The risk or severity of hypertension can be increased when Salicylic acid is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Salicylic acid is combined with Solabegron.
Asenapine The risk or severity of hypertension can be increased when Salicylic acid is combined with Asenapine.
Esmirtazapine The risk or severity of hypertension can be increased when Salicylic acid is combined with Esmirtazapine.
Vilazodone The risk or severity of hypertension can be increased when Salicylic acid is combined with Vilazodone.
Nitrous oxide The risk or severity of hypertension can be increased when Salicylic acid is combined with Nitrous oxide.
Dexmethylphenidate The risk or severity of hypertension can be increased when Salicylic acid is combined with Dexmethylphenidate.

Target Protein

Carbonic anhydrase 6 CA6
Carbonic anhydrase 12 CA12
Carbonic anhydrase 2 CA2
Carbonic anhydrase 4 CA4
Carbonic anhydrase 1 CA1
Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2
Aldo-keto reductase family 1 member C1 AKR1C1

Referensi & Sumber

Synthesis reference: Howard Jones, Robert W. Houser, "Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid." U.S. Patent US4225730, issued August, 1972.
Artikel (PubMed)
  • PMID: 5284360
    Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232-5.
  • PMID: 4505422
    Flower R, Gryglewski R, Herbaczynska-Cedro K, Vane JR: Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nat New Biol. 1972 Jul 26;238(82):104-6.

Contoh Produk & Brand

Produk: 3351 • International brands: 9
Produk
  • 111MedCo 2% Salicylic Acid Cleansing Bar
    Soap • 20 mg/1g • Topical • US • OTC
  • 2% Salicylic Acid FACIAL CLEANSER
    Liquid • - • Topical • US • OTC
  • 24 Alopecia Reliefshampoo
    Shampoo • - • Topical • US • OTC
  • 24 Hour Pimple Punisher
    Cream; Kit • 2 g/100mL • Topical • US • OTC
  • 28 Remedy Acne Pore Deep Cleanser
    Gel • 0.6 g/120mL • Topical • US • OTC
  • 28 Remedy Balancing Toner 10mL
    Cream • 0.001 mg/10mL • Topical • US • OTC
  • 28.5% Salicylic Acid
    Solution • 285 mg/1mL • Topical • US
  • 3 in 1 Cleanser
    Liquid • 1 mg/1mg • Topical • US • OTC
Menampilkan 8 dari 3351 produk.
International Brands
  • Dr. Scholl's Callus Removers
  • Dr. Scholl's Corn Removers
  • Dr. Scholl's Wart Remover Kit
  • Duofil Wart Remover
  • Duoplant
  • Ionil Plus shampoo
  • Salonil
  • Salsonin
  • Stridex

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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