Metacycline

DB00931

small molecule approved investigational

Deskripsi

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.

Struktur Molekul 2D

Berat 442.424
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 14 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

58% absorbed

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

348 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Metacycline.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Metacycline.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Metacycline.
Cisatracurium Metacycline may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Metacycline.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Metacycline.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Metacycline.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Metacycline.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Metacycline.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Metacycline.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Metacycline.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Metacycline.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Metacycline.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Metacycline.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Metacycline.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Metacycline.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Metacycline.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Metacycline.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Metacycline.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Metacycline.
Bismuth subsalicylate The serum concentration of Metacycline can be decreased when it is combined with Bismuth subsalicylate.
Mecamylamine Metacycline may increase the neuromuscular blocking activities of Mecamylamine.
Mipomersen Metacycline may increase the hepatotoxic activities of Mipomersen.
Quinapril Quinapril can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose The serum concentration of Metacycline can be decreased when it is combined with Iron sucrose.
Flucloxacillin The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Metacycline.
Piperacillin The therapeutic efficacy of Piperacillin can be decreased when used in combination with Metacycline.
Ampicillin The therapeutic efficacy of Ampicillin can be decreased when used in combination with Metacycline.
Phenoxymethylpenicillin The therapeutic efficacy of Phenoxymethylpenicillin can be decreased when used in combination with Metacycline.
Dicloxacillin The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Metacycline.
Carbenicillin The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Metacycline.
Nafcillin The therapeutic efficacy of Nafcillin can be decreased when used in combination with Metacycline.
Oxacillin The therapeutic efficacy of Oxacillin can be decreased when used in combination with Metacycline.
Hetacillin The therapeutic efficacy of Hetacillin can be decreased when used in combination with Metacycline.
Benzylpenicilloyl polylysine The therapeutic efficacy of Benzylpenicilloyl polylysine can be decreased when used in combination with Metacycline.
Mezlocillin The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Metacycline.
Cyclacillin The therapeutic efficacy of Cyclacillin can be decreased when used in combination with Metacycline.
Benzylpenicillin The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Metacycline.
Amoxicillin The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Metacycline.
Azlocillin The therapeutic efficacy of Azlocillin can be decreased when used in combination with Metacycline.
Cloxacillin The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Metacycline.
Amdinocillin The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Metacycline.
Bacampicillin The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Metacycline.
Meticillin The therapeutic efficacy of Meticillin can be decreased when used in combination with Metacycline.
Pivampicillin The therapeutic efficacy of Pivampicillin can be decreased when used in combination with Metacycline.
Pivmecillinam The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Metacycline.
Ticarcillin The therapeutic efficacy of Ticarcillin can be decreased when used in combination with Metacycline.
Azidocillin The therapeutic efficacy of Azidocillin can be decreased when used in combination with Metacycline.
Carindacillin The therapeutic efficacy of Carindacillin can be decreased when used in combination with Metacycline.
Procaine benzylpenicillin The therapeutic efficacy of Procaine benzylpenicillin can be decreased when used in combination with Metacycline.
Sultamicillin The therapeutic efficacy of Sultamicillin can be decreased when used in combination with Metacycline.
Temocillin The therapeutic efficacy of Temocillin can be decreased when used in combination with Metacycline.
Epicillin The therapeutic efficacy of Epicillin can be decreased when used in combination with Metacycline.
Pheneticillin The therapeutic efficacy of Pheneticillin can be decreased when used in combination with Metacycline.
Carfecillin The therapeutic efficacy of Carfecillin can be decreased when used in combination with Metacycline.
Propicillin The therapeutic efficacy of Propicillin can be decreased when used in combination with Metacycline.
Clometocillin The therapeutic efficacy of Clometocillin can be decreased when used in combination with Metacycline.
Sulbenicillin The therapeutic efficacy of Sulbenicillin can be decreased when used in combination with Metacycline.
Penamecillin The therapeutic efficacy of Penamecillin can be decreased when used in combination with Metacycline.
Talampicillin The therapeutic efficacy of Talampicillin can be decreased when used in combination with Metacycline.
Aspoxicillin The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Metacycline.
Metampicillin The therapeutic efficacy of Metampicillin can be decreased when used in combination with Metacycline.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Metacycline.
Bismuth subcitrate potassium The serum concentration of Metacycline can be decreased when it is combined with Bismuth subcitrate potassium.
Strontium ranelate The serum concentration of Metacycline can be decreased when it is combined with Strontium ranelate.
Calcium glucoheptonate The serum concentration of Metacycline can be decreased when it is combined with Calcium glucoheptonate.
Calcium glubionate anhydrous The serum concentration of Metacycline can be decreased when it is combined with Calcium glubionate anhydrous.
Calcium gluconate The serum concentration of Metacycline can be decreased when it is combined with Calcium gluconate.
Calcium citrate The serum concentration of Metacycline can be decreased when it is combined with Calcium citrate.
Calcium Phosphate The serum concentration of Metacycline can be decreased when it is combined with Calcium Phosphate.
Calcium lactate The serum concentration of Metacycline can be decreased when it is combined with Calcium lactate.
Calcium lactate gluconate The serum concentration of Metacycline can be decreased when it is combined with Calcium lactate gluconate.
Calcium pangamate The serum concentration of Metacycline can be decreased when it is combined with Calcium pangamate.
Calcium levulinate The serum concentration of Metacycline can be decreased when it is combined with Calcium levulinate.
Calcium acetate The serum concentration of Metacycline can be decreased when it is combined with Calcium acetate.
Calcium chloride The serum concentration of Metacycline can be decreased when it is combined with Calcium chloride.
Calcium The serum concentration of Metacycline can be decreased when it is combined with Calcium.
Calcium cation The serum concentration of Metacycline can be decreased when it is combined with Calcium cation.
Calcium polycarbophil The serum concentration of Metacycline can be decreased when it is combined with Calcium polycarbophil.
Colestipol Colestipol can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colesevelam Colesevelam can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholestyramine Cholestyramine can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium sulfate Magnesium sulfate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium salicylate Magnesium salicylate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium chloride Magnesium chloride can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium citrate Magnesium citrate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium aspartate Magnesium aspartate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium gluconate Magnesium gluconate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium orotate Magnesium orotate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium levulinate Magnesium levulinate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium lactate Magnesium lactate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium oxide Magnesium oxide can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magaldrate Magaldrate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium hydroxide Magnesium hydroxide can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium trisilicate Magnesium trisilicate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium carbonate Magnesium carbonate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium silicate Magnesium silicate can cause a decrease in the absorption of Metacycline resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

16S ribosomal RNA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16816396
    Agwuh KN, MacGowan A: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1.
  • PMID: 18585209
    Li J, Chen L, Wang X, Jin H, Ding L, Zhang K, Zhang H: Determination of tetracyclines residues in honey by on-line solid-phase extraction high-performance liquid chromatography. Talanta. 2008 Jun 15;75(5):1245-52. doi: 10.1016/j.talanta.2008.01.027. Epub 2008 Jan 20.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Rondomycin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul