Peringatan Keamanan

Symptoms of overdose may include eye irritation, constipation, abdominal cramps, nausea, vomiting, diarrhea, and hypersensitivity. However, as colesevelam is not absorbed, the risk of systemic toxicity is low. Doses in excess of 4.5 g per day have not been tested.

Colesevelam

DB00930

small molecule approved

Deskripsi

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Not hydrolyzed by digestive enzymes and is not absorbed.

Metabolisme

Not applicable (not hydrolyzed by digestive enzymes and not absorbed).

Rute Eliminasi

Excretion: In 16 healthy volunteers, an average of 0.05% of administered radioactivity from a single 14C-labeled colesevelam hydrochloride dose was excreted in the urine.

Interaksi Makanan

2 Data
  • 1. Drink plenty of fluids.
  • 2. Take with food.

Interaksi Obat

338 Data
Cyclosporine The serum concentration of Cyclosporine can be decreased when it is combined with Colesevelam.
Glimepiride Colesevelam can cause a decrease in the absorption of Glimepiride resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenytoin The serum concentration of Phenytoin can be decreased when it is combined with Colesevelam.
Fosphenytoin The serum concentration of Fosphenytoin can be decreased when it is combined with Colesevelam.
Olmesartan Colesevelam can cause a decrease in the absorption of Olmesartan resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amiodarone The excretion of Amiodarone can be increased when combined with Colesevelam.
Pravastatin Colesevelam can cause a decrease in the absorption of Pravastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lovastatin Colesevelam can cause a decrease in the absorption of Lovastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cerivastatin Colesevelam can cause a decrease in the absorption of Cerivastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Simvastatin Colesevelam can cause a decrease in the absorption of Simvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Atorvastatin Colesevelam can cause a decrease in the absorption of Atorvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluvastatin Colesevelam can cause a decrease in the absorption of Fluvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosuvastatin Colesevelam can cause a decrease in the absorption of Rosuvastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mevastatin Colesevelam can cause a decrease in the absorption of Mevastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pitavastatin Colesevelam can cause a decrease in the absorption of Pitavastatin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ursodeoxycholic acid Colesevelam can cause a decrease in the absorption of Ursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycochenodeoxycholic Acid Colesevelam can cause a decrease in the absorption of Glycochenodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic Acid Colesevelam can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycocholic acid Colesevelam can cause a decrease in the absorption of Glycocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deoxycholic acid Colesevelam can cause a decrease in the absorption of Deoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurocholic acid Colesevelam can cause a decrease in the absorption of Taurocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chenodeoxycholic acid Colesevelam can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurochenodeoxycholic acid Colesevelam can cause a decrease in the absorption of Taurochenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tauroursodeoxycholic acid Colesevelam can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bamet-UD2 Colesevelam can cause a decrease in the absorption of Bamet-UD2 resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dehydrocholic acid Colesevelam can cause a decrease in the absorption of Dehydrocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hyodeoxycholic Acid Colesevelam can cause a decrease in the absorption of Hyodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deferasirox Colesevelam can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ezetimibe Colesevelam can cause a decrease in the absorption of Ezetimibe resulting in a reduced serum concentration and potentially a decrease in efficacy.
Leflunomide Colesevelam may increase the excretion rate of Leflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Teriflunomide Colesevelam may increase the excretion rate of Teriflunomide which could result in a lower serum level and potentially a reduction in efficacy.
Lomitapide Colesevelam can cause a decrease in the absorption of Lomitapide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methotrexate Colesevelam may increase the excretion rate of Methotrexate which could result in a lower serum level and potentially a reduction in efficacy.
Niacin Colesevelam can cause a decrease in the absorption of Niacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Propranolol Colesevelam can cause a decrease in the absorption of Propranolol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raloxifene Colesevelam can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vancomycin The therapeutic efficacy of Vancomycin can be decreased when used in combination with Colesevelam.
Norethisterone The serum concentration of Norethisterone can be decreased when it is combined with Colesevelam.
Ethinylestradiol Colesevelam can cause a decrease in the absorption of Ethinylestradiol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glipizide The serum concentration of Glipizide can be decreased when it is combined with Colesevelam.
Glyburide The serum concentration of Glyburide can be decreased when it is combined with Colesevelam.
Mycophenolate mofetil Colesevelam can cause a decrease in the absorption of Mycophenolate mofetil resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolic acid Colesevelam can cause a decrease in the absorption of Mycophenolic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Digoxin Colesevelam can cause a decrease in the absorption of Digoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigitoxin Colesevelam can cause a decrease in the absorption of Acetyldigitoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deslanoside Colesevelam can cause a decrease in the absorption of Deslanoside resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ouabain Colesevelam can cause a decrease in the absorption of Ouabain resulting in a reduced serum concentration and potentially a decrease in efficacy.
Digitoxin Colesevelam can cause a decrease in the absorption of Digitoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oleandrin Colesevelam can cause a decrease in the absorption of Oleandrin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cymarin Colesevelam can cause a decrease in the absorption of Cymarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Proscillaridin Colesevelam can cause a decrease in the absorption of Proscillaridin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Metildigoxin Colesevelam can cause a decrease in the absorption of Metildigoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanatoside C Colesevelam can cause a decrease in the absorption of Lanatoside C resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gitoformate Colesevelam can cause a decrease in the absorption of Gitoformate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigoxin Colesevelam can cause a decrease in the absorption of Acetyldigoxin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Peruvoside Colesevelam can cause a decrease in the absorption of Peruvoside resulting in a reduced serum concentration and potentially a decrease in efficacy.
Desogestrel Colesevelam can cause a decrease in the absorption of Desogestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Megestrol acetate Colesevelam can cause a decrease in the absorption of Megestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levonorgestrel Colesevelam can cause a decrease in the absorption of Levonorgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Medroxyprogesterone acetate Colesevelam can cause a decrease in the absorption of Medroxyprogesterone acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Estradiol Colesevelam can cause a decrease in the absorption of Estradiol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ethynodiol diacetate Colesevelam can cause a decrease in the absorption of Ethynodiol diacetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mifepristone Colesevelam can cause a decrease in the absorption of Mifepristone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norgestimate Colesevelam can cause a decrease in the absorption of Norgestimate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Drospirenone Colesevelam can cause a decrease in the absorption of Drospirenone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cyproterone acetate Colesevelam can cause a decrease in the absorption of Cyproterone acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gestodene Colesevelam can cause a decrease in the absorption of Gestodene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dienogest Colesevelam can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norethynodrel Colesevelam can cause a decrease in the absorption of Norethynodrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norgestrel Colesevelam can cause a decrease in the absorption of Norgestrel resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gestrinone Colesevelam can cause a decrease in the absorption of Gestrinone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lynestrenol Colesevelam can cause a decrease in the absorption of Lynestrenol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ormeloxifene Colesevelam can cause a decrease in the absorption of Ormeloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chlormadinone Colesevelam can cause a decrease in the absorption of Chlormadinone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norgestrienone Colesevelam can cause a decrease in the absorption of Norgestrienone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quingestanol Colesevelam can cause a decrease in the absorption of Quingestanol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Demegestone Colesevelam can cause a decrease in the absorption of Demegestone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nomegestrol acetate Colesevelam can cause a decrease in the absorption of Nomegestrol acetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norethindrone enanthate Colesevelam can cause a decrease in the absorption of Norethindrone enanthate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Estetrol Colesevelam can cause a decrease in the absorption of Estetrol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hydroxyprogesterone caproate The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Colesevelam.
Clofibrate Colesevelam can cause a decrease in the absorption of Clofibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fenofibrate Colesevelam can cause a decrease in the absorption of Fenofibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemfibrozil Colesevelam can cause a decrease in the absorption of Gemfibrozil resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bezafibrate Colesevelam can cause a decrease in the absorption of Bezafibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Etofibrate Colesevelam can cause a decrease in the absorption of Etofibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofibrate Colesevelam can cause a decrease in the absorption of Ciprofibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Simfibrate Colesevelam can cause a decrease in the absorption of Simfibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ronifibrate Colesevelam can cause a decrease in the absorption of Ronifibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium clofibrate Colesevelam can cause a decrease in the absorption of Aluminium clofibrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clofibride Colesevelam can cause a decrease in the absorption of Clofibride resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fenofibric acid Colesevelam can cause a decrease in the absorption of Fenofibric acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Icosapent Colesevelam can cause a decrease in the absorption of Icosapent resulting in a reduced serum concentration and potentially a decrease in efficacy.
Indomethacin Colesevelam can cause a decrease in the absorption of Indomethacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nabumetone Colesevelam can cause a decrease in the absorption of Nabumetone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ketorolac Colesevelam can cause a decrease in the absorption of Ketorolac resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tenoxicam Colesevelam can cause a decrease in the absorption of Tenoxicam resulting in a reduced serum concentration and potentially a decrease in efficacy.
Celecoxib Colesevelam can cause a decrease in the absorption of Celecoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolmetin Colesevelam can cause a decrease in the absorption of Tolmetin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rofecoxib Colesevelam can cause a decrease in the absorption of Rofecoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

Bile acids

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 54 • International brands: 0
Produk
  • Apo-colesevelam
    Tablet • 625 mg • Oral • Canada • Generic • Approved
  • Cholestagel
    Tablet, film coated • 625 mg • Oral • EU • Approved
  • Cholestagel
    Tablet, film coated • 625 mg • Oral • EU • Approved
  • Cholestagel
    Tablet, film coated • 625 mg • Oral • EU • Approved
  • Cholestagel
    Tablet, film coated • 625 mg • Oral • EU • Approved
  • Colesevelam
    Tablet • 625 mg/1 • Oral • US • Generic • Approved
  • Colesevelam
    Tablet, film coated • 625 mg/1 • Oral • US • Generic • Approved
  • Colesevelam HCL
    Tablet, film coated • 625 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 54 produk.

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