Peringatan Keamanan

Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock.

Phenoxybenzamine

DB00925

small molecule approved

Deskripsi

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Struktur Molekul 2D

Berat 303.826
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 24 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

735 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Phenoxybenzamine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Phenoxybenzamine is combined with Levodopa.
Risperidone Phenoxybenzamine may increase the hypotensive activities of Risperidone.
Amifostine Phenoxybenzamine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Phenoxybenzamine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Phenoxybenzamine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Phenoxybenzamine.
Obinutuzumab Phenoxybenzamine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Phenoxybenzamine.
Rituximab Phenoxybenzamine may increase the hypotensive activities of Rituximab.
Yohimbine Yohimbine may decrease the antihypertensive activities of Phenoxybenzamine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Phenoxybenzamine.
Siponimod Siponimod may decrease the antihypertensive activities of Phenoxybenzamine.
Valsartan Phenoxybenzamine may decrease the antihypertensive activities of Valsartan.
Ramipril Phenoxybenzamine may decrease the antihypertensive activities of Ramipril.
Torasemide Phenoxybenzamine may decrease the antihypertensive activities of Torasemide.
Olmesartan Phenoxybenzamine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Phenoxybenzamine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Phenoxybenzamine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Phenoxybenzamine may decrease the antihypertensive activities of Minoxidil.
Fosinopril Phenoxybenzamine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Phenoxybenzamine may decrease the antihypertensive activities of Trandolapril.
Metolazone Phenoxybenzamine may decrease the antihypertensive activities of Metolazone.
Benazepril Phenoxybenzamine may decrease the antihypertensive activities of Benazepril.
Enalapril Phenoxybenzamine may decrease the antihypertensive activities of Enalapril.
Mecamylamine Phenoxybenzamine may decrease the antihypertensive activities of Mecamylamine.
Losartan Phenoxybenzamine may decrease the antihypertensive activities of Losartan.
Moexipril Phenoxybenzamine may decrease the antihypertensive activities of Moexipril.
Furosemide Phenoxybenzamine may decrease the antihypertensive activities of Furosemide.
Eplerenone Phenoxybenzamine may decrease the antihypertensive activities of Eplerenone.
Sufentanil Sufentanil may decrease the antihypertensive activities of Phenoxybenzamine.
Lisinopril Phenoxybenzamine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Phenoxybenzamine may decrease the antihypertensive activities of Nitroglycerin.
Isoflurane Isoflurane may decrease the antihypertensive activities of Phenoxybenzamine.
Perindopril Phenoxybenzamine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Phenoxybenzamine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Phenoxybenzamine may decrease the antihypertensive activities of Fenoldopam.
Propofol Propofol may decrease the antihypertensive activities of Phenoxybenzamine.
Eprosartan Phenoxybenzamine may decrease the antihypertensive activities of Eprosartan.
Quinapril Phenoxybenzamine may decrease the antihypertensive activities of Quinapril.
Remifentanil Remifentanil may decrease the antihypertensive activities of Phenoxybenzamine.
Remikiren Phenoxybenzamine may decrease the antihypertensive activities of Remikiren.
Guanadrel Phenoxybenzamine may decrease the antihypertensive activities of Guanadrel.
Bosentan Phenoxybenzamine may decrease the antihypertensive activities of Bosentan.
Candoxatril Phenoxybenzamine may decrease the antihypertensive activities of Candoxatril.
Metyrosine Phenoxybenzamine may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Phenoxybenzamine may decrease the antihypertensive activities of Cryptenamine.
Omapatrilat Omapatrilat may decrease the antihypertensive activities of Phenoxybenzamine.
Telmisartan Phenoxybenzamine may decrease the antihypertensive activities of Telmisartan.
Irbesartan Phenoxybenzamine may decrease the antihypertensive activities of Irbesartan.
Deserpidine Phenoxybenzamine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Phenoxybenzamine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Phenoxybenzamine may decrease the antihypertensive activities of Trimethaphan.
Bretylium Phenoxybenzamine may decrease the antihypertensive activities of Bretylium.
Guanethidine Phenoxybenzamine may decrease the antihypertensive activities of Guanethidine.
Rescinnamine Phenoxybenzamine may decrease the antihypertensive activities of Rescinnamine.
Captopril Phenoxybenzamine may decrease the antihypertensive activities of Captopril.
Hydralazine Phenoxybenzamine may decrease the antihypertensive activities of Hydralazine.
Cilazapril Phenoxybenzamine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Phenoxybenzamine may decrease the antihypertensive activities of Saprisartan.
Spirapril Phenoxybenzamine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Phenoxybenzamine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Phenoxybenzamine may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Phenoxybenzamine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Phenoxybenzamine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Phenoxybenzamine may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Phenoxybenzamine may decrease the antihypertensive activities of Pinacidil.
Temocapril Phenoxybenzamine may decrease the antihypertensive activities of Temocapril.
Riociguat Phenoxybenzamine may decrease the antihypertensive activities of Riociguat.
Macitentan Phenoxybenzamine may decrease the antihypertensive activities of Macitentan.
Hexamethonium Phenoxybenzamine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Phenoxybenzamine may decrease the antihypertensive activities of Aliskiren.
Rauwolfia serpentina root Phenoxybenzamine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Phenoxybenzamine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Phenoxybenzamine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Phenoxybenzamine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Phenoxybenzamine may decrease the antihypertensive activities of Imidapril.
BQ-123 Phenoxybenzamine may decrease the antihypertensive activities of BQ-123.
Cicletanine Phenoxybenzamine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Phenoxybenzamine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Phenoxybenzamine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Phenoxybenzamine may decrease the antihypertensive activities of Guanoxan.
Delapril Phenoxybenzamine may decrease the antihypertensive activities of Delapril.
Vincamine Phenoxybenzamine may decrease the antihypertensive activities of Vincamine.
Linsidomine Phenoxybenzamine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Phenoxybenzamine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Phenoxybenzamine may decrease the antihypertensive activities of Tolonidine.
Endralazine Phenoxybenzamine may decrease the antihypertensive activities of Endralazine.
Cadralazine Phenoxybenzamine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Phenoxybenzamine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Phenoxybenzamine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Phenoxybenzamine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Phenoxybenzamine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Phenoxybenzamine may decrease the antihypertensive activities of Muzolimine.
Xipamide Phenoxybenzamine may decrease the antihypertensive activities of Xipamide.
Candesartan Phenoxybenzamine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Phenoxybenzamine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Phenoxybenzamine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Phenoxybenzamine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Phenoxybenzamine may decrease the antihypertensive activities of Ramiprilat.

Target Protein

D(2) dopamine receptor DRD2
Alpha-1A adrenergic receptor ADRA1A
Alpha-2A adrenergic receptor ADRA2A
Alpha-2C adrenergic receptor ADRA2C
Alpha-2B adrenergic receptor ADRA2B
Beta-2 adrenergic receptor ADRB2
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
Calmodulin CALM1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 88984
    Caine M, Perlberg S, Meretyk S: A placebo-controlled double-blind study of the effect of phenoxybenzamine in benign prostatic obstruction. Br J Urol. 1978 Dec;50(7):551-4.
  • PMID: 11395517
    Frang H, Cockcroft V, Karskela T, Scheinin M, Marjamaki A: Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors. J Biol Chem. 2001 Aug 17;276(33):31279-84. Epub 2001 Jun 6.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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