Peringatan Keamanan

Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.

Ceforanide

DB00923

small molecule approved

Deskripsi

Ceforanide is administered parenterally. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, another second-generation cephalosporin antibiotic, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.

Struktur Molekul 2D

Berat 519.554
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.6 to 2.98 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed following intramuscular injection.

Metabolisme

The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

796 Data
Probenecid The serum concentration of Ceforanide can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Ceforanide.
Tenofovir disoproxil Ceforanide may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide Ceforanide may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir Ceforanide may increase the nephrotoxic activities of Tenofovir.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ceforanide.
Cyclosporine The risk or severity of nephrotoxicity can be increased when Cyclosporine is combined with Ceforanide.
Icosapent The risk or severity of nephrotoxicity can be increased when Icosapent is combined with Ceforanide.
Cefotiam The risk or severity of nephrotoxicity can be increased when Cefotiam is combined with Ceforanide.
Mesalazine The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Ceforanide.
Cefmenoxime The risk or severity of nephrotoxicity can be increased when Cefmenoxime is combined with Ceforanide.
Cefmetazole The risk or severity of nephrotoxicity can be increased when Cefmetazole is combined with Ceforanide.
Indomethacin The risk or severity of nephrotoxicity can be increased when Indomethacin is combined with Ceforanide.
Triamterene The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Ceforanide.
Cefpiramide The risk or severity of nephrotoxicity can be increased when Cefpiramide is combined with Ceforanide.
Loracarbef The risk or severity of nephrotoxicity can be increased when Loracarbef is combined with Ceforanide.
Cefalotin The risk or severity of nephrotoxicity can be increased when Cefalotin is combined with Ceforanide.
Nabumetone The risk or severity of nephrotoxicity can be increased when Nabumetone is combined with Ceforanide.
Ketorolac The risk or severity of nephrotoxicity can be increased when Ketorolac is combined with Ceforanide.
Tenoxicam The risk or severity of nephrotoxicity can be increased when Tenoxicam is combined with Ceforanide.
Celecoxib The risk or severity of nephrotoxicity can be increased when Celecoxib is combined with Ceforanide.
Cefotaxime The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Ceforanide.
Tolmetin The risk or severity of nephrotoxicity can be increased when Tolmetin is combined with Ceforanide.
Rofecoxib The risk or severity of nephrotoxicity can be increased when Rofecoxib is combined with Ceforanide.
Fenoprofen The risk or severity of nephrotoxicity can be increased when Fenoprofen is combined with Ceforanide.
Valdecoxib The risk or severity of nephrotoxicity can be increased when Valdecoxib is combined with Ceforanide.
Diclofenac The risk or severity of nephrotoxicity can be increased when Diclofenac is combined with Ceforanide.
Sulindac The risk or severity of nephrotoxicity can be increased when Sulindac is combined with Ceforanide.
Bacitracin The risk or severity of nephrotoxicity can be increased when Bacitracin is combined with Ceforanide.
Amphotericin B The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Ceforanide.
Cephaloglycin The risk or severity of nephrotoxicity can be increased when Cephaloglycin is combined with Ceforanide.
Adefovir dipivoxil The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Ceforanide.
Pentamidine The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Ceforanide.
Mefenamic acid The risk or severity of nephrotoxicity can be increased when Mefenamic acid is combined with Ceforanide.
Naproxen The risk or severity of nephrotoxicity can be increased when Naproxen is combined with Ceforanide.
Sulfasalazine The risk or severity of nephrotoxicity can be increased when Sulfasalazine is combined with Ceforanide.
Phenylbutazone The risk or severity of nephrotoxicity can be increased when Phenylbutazone is combined with Ceforanide.
Meloxicam The risk or severity of methemoglobinemia can be increased when Ceforanide is combined with Meloxicam.
Carprofen The risk or severity of nephrotoxicity can be increased when Carprofen is combined with Ceforanide.
Tacrolimus The risk or severity of nephrotoxicity can be increased when Tacrolimus is combined with Ceforanide.
Etacrynic acid The risk or severity of nephrotoxicity can be increased when Etacrynic acid is combined with Ceforanide.
Salicylic acid The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Salicylic acid.
Acetylsalicylic acid The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Acetylsalicylic acid.
Hydrochlorothiazide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Hydrochlorothiazide.
Balsalazide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Balsalazide.
Cefditoren The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefditoren.
Atazanavir The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Atazanavir.
Colistimethate The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Colistimethate.
Cefuroxime The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefuroxime.
Cefapirin The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefapirin.
Cefprozil The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefprozil.
Olsalazine The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Olsalazine.
Lumiracoxib The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Lumiracoxib.
Cefamandole The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefamandole.
Cefazolin The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefazolin.
Cefonicid The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefonicid.
Cefoperazone The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefoperazone.
Cefoxitin The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefoxitin.
Ceftizoxime The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Ceftizoxime.
Magnesium salicylate The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Magnesium salicylate.
Salsalate The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Choline magnesium trisalicylate.
Cefepime The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefepime.
Cefacetrile The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefacetrile.
Cefpodoxime The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefpodoxime.
Antrafenine The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Antrafenine.
Aminophenazone The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Aminophenazone.
Antipyrine The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Antipyrine.
Tiaprofenic acid The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Tiaprofenic acid.
Lopinavir The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Lopinavir.
Etoricoxib The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Etoricoxib.
Hydrolyzed Cephalothin The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Hydrolyzed Cephalothin.
Cephalothin Group The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cephalothin Group.
Oxyphenbutazone The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Oxyphenbutazone.
Latamoxef The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Latamoxef.
Nimesulide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Nimesulide.
Benoxaprofen The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Benoxaprofen.
Metamizole The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Metamizole.
Zomepirac The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Zomepirac.
Ceftobiprole The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Ceftobiprole.
Cimicoxib The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cimicoxib.
Ceftaroline fosamil The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Ceftaroline fosamil.
Lornoxicam The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Lornoxicam.
Zaltoprofen The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Zaltoprofen.
Azapropazone The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Azapropazone.
Parecoxib The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Parecoxib.
Salicylamide The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Salicylamide.
Kebuzone The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Kebuzone.
Isoxicam The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Isoxicam.
Indoprofen The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Indoprofen.
Ibuproxam The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Ibuproxam.
Floctafenine The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Floctafenine.
Fenbufen The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Fenbufen.
Etofenamate The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Etofenamate.
Epirizole The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Epirizole.
Cefaloridine The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefaloridine.
Cefminox The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Cefminox.
Dexibuprofen The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Dexibuprofen.
Droxicam The risk or severity of nephrotoxicity can be increased when Ceforanide is combined with Droxicam.

Target Protein

Penicillin-binding protein 2 pbpA

Referensi & Sumber

Artikel (PubMed)
  • PMID: 3140456
    Crowle AJ, Sbarbaro JA, May MH: Effects of isoniazid and of ceforanide against virulent tubercle bacilli in cultured human macrophages. Tubercle. 1988 Mar;69(1):15-25.
  • PMID: 3315624
    Campoli-Richards DM, Lackner TE, Monk JP: Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Drugs. 1987 Oct;34(4):411-37.
  • PMID: 3814386
    Cone LA, Barton SM, Woodard DR: Treatment of scleroma with ceforanide. Arch Otolaryngol Head Neck Surg. 1987 Apr;113(4):374-6.
  • PMID: 6762529
    Barriere SL, Mills J: Ceforanide: antibacterial activity, pharmacology, and clinical efficacy. Pharmacotherapy. 1982 Nov-Dec;2(6):322-7.

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Produk: 0 • International brands: 1
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