Levosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ivabradine | Ivabradine may increase the QTc-prolonging activities of Levosimendan. |
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Levosimendan is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Levosimendan is combined with Levodopa. |
| Risperidone | Levosimendan may increase the hypotensive activities of Risperidone. |
| Nicorandil | Nicorandil may increase the hypotensive activities of Levosimendan. |
| Lidocaine | Lidocaine may increase the arrhythmogenic activities of Levosimendan. |
| Mexiletine | Mexiletine may increase the arrhythmogenic activities of Levosimendan. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Levosimendan. |
| Magnesium sulfate | Magnesium sulfate may increase the arrhythmogenic activities of Levosimendan. |
| Carteolol | Levosimendan may increase the arrhythmogenic activities of Carteolol. |
| Tocainide | Levosimendan may increase the arrhythmogenic activities of Tocainide. |
| Deslanoside | Levosimendan may increase the arrhythmogenic activities of Deslanoside. |
| Metipranolol | Levosimendan may increase the arrhythmogenic activities of Metipranolol. |
| Aprindine | Levosimendan may increase the arrhythmogenic activities of Aprindine. |
| Nimesulide | Levosimendan may increase the arrhythmogenic activities of Nimesulide. |
| Cyclandelate | Levosimendan may increase the arrhythmogenic activities of Cyclandelate. |
| Flunarizine | Levosimendan may increase the arrhythmogenic activities of Flunarizine. |
| Seletracetam | Levosimendan may increase the arrhythmogenic activities of Seletracetam. |
| Nylidrin | Levosimendan may increase the arrhythmogenic activities of Nylidrin. |
| Dotarizine | Levosimendan may increase the arrhythmogenic activities of Dotarizine. |
| Xylometazoline | Levosimendan may increase the arrhythmogenic activities of Xylometazoline. |
| Sparteine | Levosimendan may increase the arrhythmogenic activities of Sparteine. |
| Tranilast | Levosimendan may increase the arrhythmogenic activities of Tranilast. |
| Fasudil | Levosimendan may increase the arrhythmogenic activities of Fasudil. |
| Agmatine | Levosimendan may increase the arrhythmogenic activities of Agmatine. |
| Azelnidipine | Levosimendan may increase the arrhythmogenic activities of Azelnidipine. |
| Darodipine | Levosimendan may increase the arrhythmogenic activities of Darodipine. |
| Niludipine | Levosimendan may increase the arrhythmogenic activities of Niludipine. |
| Tropisetron | Levosimendan may increase the arrhythmogenic activities of Tropisetron. |
| Carboxyamidotriazole | Levosimendan may increase the arrhythmogenic activities of Carboxyamidotriazole. |
| Vinpocetine | Levosimendan may increase the arrhythmogenic activities of Vinpocetine. |
| Spiradoline | Levosimendan may increase the arrhythmogenic activities of Spiradoline. |
| Cymarin | Levosimendan may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Levosimendan may increase the arrhythmogenic activities of Metildigoxin. |
| Tiracizine | Levosimendan may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Levosimendan may increase the arrhythmogenic activities of Ethacizine. |
| Hydroquinine | Levosimendan may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Levosimendan may increase the arrhythmogenic activities of Bioallethrin. |
| Tertatolol | Levosimendan may increase the arrhythmogenic activities of Tertatolol. |
| Caroverine | Levosimendan may increase the arrhythmogenic activities of Caroverine. |
| Fosfructose | Levosimendan may increase the arrhythmogenic activities of Fosfructose. |
| WIN 55212-2 | Levosimendan may increase the arrhythmogenic activities of WIN 55212-2. |
| Fish oil | Levosimendan may increase the arrhythmogenic activities of Fish oil. |
| Emopamil | Levosimendan may increase the arrhythmogenic activities of Emopamil. |
| Lomerizine | Levosimendan may increase the arrhythmogenic activities of Lomerizine. |
| Tetrandrine | Levosimendan may increase the arrhythmogenic activities of Tetrandrine. |
| Hydroquinidine | Levosimendan may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Levosimendan may increase the arrhythmogenic activities of SOR-C13. |
| Dofetilide | Dofetilide may increase the arrhythmogenic activities of Levosimendan. |
| Disopyramide | Disopyramide may increase the arrhythmogenic activities of Levosimendan. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Levosimendan. |
| Sotalol | Sotalol may increase the arrhythmogenic activities of Levosimendan. |
| Quinidine | Quinidine may increase the arrhythmogenic activities of Levosimendan. |
| Procainamide | Levosimendan may increase the arrhythmogenic activities of Procainamide. |
| Bepridil | Levosimendan may increase the arrhythmogenic activities of Bepridil. |
| Dronedarone | Levosimendan may increase the arrhythmogenic activities of Dronedarone. |
| Terodiline | Levosimendan may increase the arrhythmogenic activities of Terodiline. |
| Betaxolol | Betaxolol may increase the arrhythmogenic activities of Levosimendan. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Levosimendan. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Levosimendan. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Levosimendan. |
| Propranolol | Propranolol may increase the arrhythmogenic activities of Levosimendan. |
| Atropine | Atropine may increase the arrhythmogenic activities of Levosimendan. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Levosimendan. |
| Loperamide | Loperamide may increase the arrhythmogenic activities of Levosimendan. |
| Nifedipine | Levosimendan may increase the arrhythmogenic activities of Nifedipine. |
| Propafenone | Levosimendan may increase the arrhythmogenic activities of Propafenone. |
| Acebutolol | Levosimendan may increase the arrhythmogenic activities of Acebutolol. |
| Flecainide | Levosimendan may increase the arrhythmogenic activities of Flecainide. |
| Mibefradil | Levosimendan may increase the arrhythmogenic activities of Mibefradil. |
| Oxprenolol | Levosimendan may increase the arrhythmogenic activities of Oxprenolol. |
| Prenylamine | Levosimendan may increase the arrhythmogenic activities of Prenylamine. |
| Fluspirilene | Levosimendan may increase the arrhythmogenic activities of Fluspirilene. |
| Azimilide | Levosimendan may increase the arrhythmogenic activities of Azimilide. |
| Tedisamil | Levosimendan may increase the arrhythmogenic activities of Tedisamil. |
| Nilvadipine | Levosimendan may increase the arrhythmogenic activities of Nilvadipine. |
| Fendiline | Levosimendan may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Levosimendan may increase the arrhythmogenic activities of Eperisone. |
| Melperone | Levosimendan may increase the arrhythmogenic activities of Melperone. |
| Benidipine | Levosimendan may increase the arrhythmogenic activities of Benidipine. |
| Otilonium | Levosimendan may increase the arrhythmogenic activities of Otilonium. |
| Nizofenone | Levosimendan may increase the arrhythmogenic activities of Nizofenone. |
| Bunaftine | Levosimendan may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Levosimendan may increase the arrhythmogenic activities of Lorcainide. |
| Penfluridol | Levosimendan may increase the arrhythmogenic activities of Penfluridol. |
| Dexverapamil | Levosimendan may increase the arrhythmogenic activities of Dexverapamil. |
| Esmolol | Esmolol may increase the arrhythmogenic activities of Levosimendan. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Levosimendan. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Levosimendan. |
| Timolol | Timolol may increase the arrhythmogenic activities of Levosimendan. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Levosimendan. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Levosimendan. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Levosimendan. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Levosimendan. |
| Ethosuximide | Ethosuximide may increase the arrhythmogenic activities of Levosimendan. |
| Nicardipine | Nicardipine may increase the arrhythmogenic activities of Levosimendan. |
| Verapamil | Verapamil may increase the arrhythmogenic activities of Levosimendan. |
| Losartan | Losartan may increase the arrhythmogenic activities of Levosimendan. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Levosimendan. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Levosimendan. |