Almotriptan

DB00918

small molecule approved investigational

Deskripsi

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Almotriptan does not prevent migraine attacks.

Struktur Molekul 2D

Berat 335.464
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3-4 hours
Volume Distribusi * 180 to 200 L
Klirens (Clearance) * 57 L/h [healthy] * 34.2 L/h [moderate renal impairment (creatinine clearance between 31 and 71 mL/min)] * 9.8 L/h [severe renal impairment (creatinine clearance between 10 and 30 mL/min)]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Almotriptan is eliminated primarily by renal excretion (about 75% of the oral dose), with approximately 40% of an administered dose excreted unchanged in urine. Approximately 13% of the administered dose is excreted via feces, both unchanged and metabolized.

Farmakogenomik

1 Varian
GNB3 (rs5443)

Patients with this genotype have an increased likelihood of responding to almotriptan when treating cluster headache.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1801 Data
Valsartan Almotriptan may decrease the antihypertensive activities of Valsartan.
Ramipril Almotriptan may decrease the antihypertensive activities of Ramipril.
Remikiren Almotriptan may decrease the antihypertensive activities of Remikiren.
Guanadrel Almotriptan may decrease the antihypertensive activities of Guanadrel.
Olmesartan Almotriptan may decrease the antihypertensive activities of Olmesartan.
Minoxidil Almotriptan may decrease the antihypertensive activities of Minoxidil.
Treprostinil The metabolism of Almotriptan can be decreased when combined with Treprostinil.
Prazosin Almotriptan may decrease the antihypertensive activities of Prazosin.
Trandolapril Almotriptan may decrease the antihypertensive activities of Trandolapril.
Benazepril Almotriptan may decrease the antihypertensive activities of Benazepril.
Candoxatril Almotriptan may decrease the antihypertensive activities of Candoxatril.
Moexipril Almotriptan may decrease the antihypertensive activities of Moexipril.
Nitroglycerin Almotriptan may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Almotriptan may decrease the antihypertensive activities of Cryptenamine.
Eprosartan Almotriptan may decrease the antihypertensive activities of Eprosartan.
Quinapril Almotriptan may decrease the antihypertensive activities of Quinapril.
Telmisartan Almotriptan may decrease the antihypertensive activities of Telmisartan.
Deserpidine Almotriptan may decrease the antihypertensive activities of Deserpidine.
Pentolinium Almotriptan may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Almotriptan may decrease the antihypertensive activities of Trimethaphan.
Bretylium Almotriptan may decrease the antihypertensive activities of Bretylium.
Terazosin Almotriptan may decrease the antihypertensive activities of Terazosin.
Cilazapril Almotriptan may decrease the antihypertensive activities of Cilazapril.
Saprisartan Almotriptan may decrease the antihypertensive activities of Saprisartan.
Spirapril Almotriptan may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Almotriptan may decrease the antihypertensive activities of Dexpropranolol.
Diethylnorspermine Almotriptan may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Almotriptan may decrease the antihypertensive activities of Temocapril.
Trimazosin Almotriptan may decrease the antihypertensive activities of Trimazosin.
Rauwolfia serpentina root Almotriptan may decrease the antihypertensive activities of Rauwolfia serpentina root.
Angiotensin 1-7 Almotriptan may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Almotriptan may decrease the antihypertensive activities of Imidapril.
BQ-123 Almotriptan may decrease the antihypertensive activities of BQ-123.
Dihydralazine Almotriptan may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Almotriptan may decrease the antihypertensive activities of Zofenopril.
Guanoxan Almotriptan may decrease the antihypertensive activities of Guanoxan.
Delapril Almotriptan may decrease the antihypertensive activities of Delapril.
Vincamine Almotriptan may decrease the antihypertensive activities of Vincamine.
Linsidomine Almotriptan may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Almotriptan may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Almotriptan may decrease the antihypertensive activities of Tolonidine.
Endralazine Almotriptan may decrease the antihypertensive activities of Endralazine.
Cadralazine Almotriptan may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Almotriptan may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Almotriptan may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Almotriptan may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Almotriptan may decrease the antihypertensive activities of Guanoclor.
Tocopherylquinone Almotriptan may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Almotriptan may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Almotriptan may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Almotriptan may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Almotriptan may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Almotriptan may decrease the antihypertensive activities of Quinaprilat.
Enalapril Almotriptan may decrease the antihypertensive activities of Enalapril.
Captopril Almotriptan may decrease the antihypertensive activities of Captopril.
Nimodipine Almotriptan may decrease the antihypertensive activities of Nimodipine.
Bosentan Almotriptan may decrease the antihypertensive activities of Bosentan.
Doxazosin Almotriptan may decrease the antihypertensive activities of Doxazosin.
Nitrendipine Almotriptan may decrease the antihypertensive activities of Nitrendipine.
Carvedilol Almotriptan may decrease the antihypertensive activities of Carvedilol.
Nebivolol Almotriptan may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Almotriptan may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Almotriptan may decrease the antihypertensive activities of Ambrisentan.
Pinacidil Almotriptan may decrease the antihypertensive activities of Pinacidil.
Aliskiren Almotriptan may decrease the antihypertensive activities of Aliskiren.
Lacidipine Almotriptan may decrease the antihypertensive activities of Lacidipine.
Niguldipine Almotriptan may decrease the antihypertensive activities of Niguldipine.
Naftopidil Almotriptan may decrease the antihypertensive activities of Naftopidil.
Dexniguldipine Almotriptan may decrease the antihypertensive activities of Dexniguldipine.
Amlodipine Almotriptan may decrease the antihypertensive activities of Amlodipine.
Levamlodipine Almotriptan may decrease the antihypertensive activities of Levamlodipine.
Lercanidipine Almotriptan may decrease the antihypertensive activities of Lercanidipine.
Azilsartan medoxomil Almotriptan may decrease the antihypertensive activities of Azilsartan medoxomil.
Diazoxide Almotriptan may decrease the antihypertensive activities of Diazoxide.
Buprenorphine Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Hydrocodone Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Magnesium sulfate The therapeutic efficacy of Almotriptan can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Almotriptan may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Orphenadrine Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Pramipexole Almotriptan may increase the sedative activities of Pramipexole.
Ropinirole Almotriptan may increase the sedative activities of Ropinirole.
Rotigotine Almotriptan may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Almotriptan.
Sodium oxybate Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Almotriptan.
Thalidomide Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Bethanidine Almotriptan may decrease the antihypertensive activities of Bethanidine.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Almotriptan.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Almotriptan.

Target Protein

5-hydroxytryptamine receptor 1D HTR1D
5-hydroxytryptamine receptor 1B HTR1B

Referensi & Sumber

Synthesis reference: Ramasubramanian Sridharan, Vandanapu Purushotham, Kori Algooram, Nitin Pradhan, "Crystalline forms of almotriptan and processes for their preparation." U.S. Patent US20070112055, issued May 17, 2007.

Contoh Produk & Brand

Produk: 24 • International brands: 1
Produk
  • Almotriptan
    Tablet, film coated • 6.25 mg/1 • Oral • US • Generic • Approved
  • Almotriptan
    Tablet, film coated • 12.5 mg/1 • Oral • US • Generic • Approved
  • Almotriptan
    Tablet • 12.5 mg • Oral • Canada • Approved
  • Almotriptan
    Tablet • 12.5 mg • Oral • Canada • Approved
  • Almotriptan Malate
    Tablet, film coated • 6.25 mg/1 • Oral • US • Generic • Approved
  • Almotriptan Malate
    Tablet, film coated • 12.5 mg/1 • Oral • US • Generic • Approved
  • Almotriptan Malate
    Tablet, film coated • 6.25 mg/1 • Oral • US • Generic • Approved
  • Almotriptan Malate
    Tablet, film coated • 12.5 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 24 produk.
International Brands
  • Almogran

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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