Peringatan Keamanan

Oral, mouse: LD50 = 750 mg/kg; Oral, rat: LD50 = 500 mg/kg.

Dinoprostone

DB00917

small molecule approved

Deskripsi

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Struktur Molekul 2D

Berat 352.4651
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Less than 5 minutes.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Metabolisme

Rapid metabolism of dinoprostone occurs primarily in the local tissues; any systemic absorption of the medication is cleared mainly in the maternal lungs and, secondarily, at sites such as the liver and kidneys.

Rute Eliminasi

The major route of elimination of the products of PGE2 metabolism is the kidneys.

Interaksi Obat

310 Data
Carboprost tromethamine Carboprost tromethamine may increase the uterotonic activities of Dinoprostone.
Oxytocin The risk or severity of adverse effects can be increased when Dinoprostone is combined with Oxytocin.
Aspartame The excretion of Dinoprostone can be decreased when combined with Aspartame.
Pravastatin The excretion of Dinoprostone can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Dinoprostone can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Dinoprostone can be decreased when combined with Cefotiam.
Liothyronine The excretion of Dinoprostone can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Dinoprostone can be decreased when combined with Conjugated estrogens.
Indomethacin The excretion of Dinoprostone can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Dinoprostone can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Dinoprostone can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Dinoprostone can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Dinoprostone can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Dinoprostone can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Dinoprostone can be decreased when combined with Zidovudine.
Guanidine The excretion of Dinoprostone can be decreased when combined with Guanidine.
Piroxicam The excretion of Dinoprostone can be decreased when combined with Piroxicam.
Methotrexate The excretion of Dinoprostone can be decreased when combined with Methotrexate.
Cephalexin The excretion of Dinoprostone can be decreased when combined with Cephalexin.
Enalapril The excretion of Dinoprostone can be decreased when combined with Enalapril.
Diclofenac The excretion of Dinoprostone can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Dinoprostone can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Dinoprostone can be decreased when combined with Leucovorin.
Furosemide The excretion of Dinoprostone can be decreased when combined with Furosemide.
Esomeprazole The excretion of Dinoprostone can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Dinoprostone can be decreased when combined with Tetracycline.
Phenylbutazone The excretion of Dinoprostone can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Dinoprostone can be decreased when combined with Cefaclor.
Bumetanide The excretion of Dinoprostone can be decreased when combined with Bumetanide.
Quinidine The excretion of Dinoprostone can be decreased when combined with Quinidine.
Succinic acid The excretion of Succinic acid can be decreased when combined with Dinoprostone.
Citrulline The excretion of Citrulline can be decreased when combined with Dinoprostone.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Dinoprostone.
Tenofovir disoproxil The excretion of Tenofovir disoproxil can be decreased when combined with Dinoprostone.
Piperacillin The excretion of Piperacillin can be decreased when combined with Dinoprostone.
Trifluridine The excretion of Trifluridine can be decreased when combined with Dinoprostone.
Allopurinol The excretion of Allopurinol can be decreased when combined with Dinoprostone.
Cefdinir The excretion of Cefdinir can be decreased when combined with Dinoprostone.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Dinoprostone.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Dinoprostone.
Fluorescein The excretion of Fluorescein can be decreased when combined with Dinoprostone.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Dinoprostone.
Estradiol The excretion of Estradiol can be decreased when combined with Dinoprostone.
Quinapril The excretion of Quinapril can be decreased when combined with Dinoprostone.
Famotidine The excretion of Famotidine can be decreased when combined with Dinoprostone.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Dinoprostone.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Dinoprostone.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Dinoprostone.
Captopril The excretion of Captopril can be decreased when combined with Dinoprostone.
Sitagliptin The excretion of Sitagliptin can be decreased when combined with Dinoprostone.
Cefazolin The excretion of Cefazolin can be decreased when combined with Dinoprostone.
Ceftizoxime The excretion of Ceftizoxime can be decreased when combined with Dinoprostone.
Cefacetrile The excretion of Cefacetrile can be decreased when combined with Dinoprostone.
Ceftibuten The excretion of Ceftibuten can be decreased when combined with Dinoprostone.
Tazobactam The excretion of Tazobactam can be decreased when combined with Dinoprostone.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Dinoprostone.
Cholic Acid The excretion of Cholic Acid can be decreased when combined with Dinoprostone.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Dinoprostone.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Dinoprostone.
Taurocholic acid The excretion of Taurocholic acid can be decreased when combined with Dinoprostone.
Doripenem The excretion of Doripenem can be decreased when combined with Dinoprostone.
Saxagliptin The excretion of Saxagliptin can be decreased when combined with Dinoprostone.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Dinoprostone.
Cefaloridine The excretion of Cefaloridine can be decreased when combined with Dinoprostone.
Avibactam The excretion of Avibactam can be decreased when combined with Dinoprostone.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Dinoprostone.
Silibinin The excretion of Silibinin can be decreased when combined with Dinoprostone.
Tenofovir alafenamide The excretion of Tenofovir alafenamide can be decreased when combined with Dinoprostone.
Baricitinib The serum concentration of Baricitinib can be increased when it is combined with Dinoprostone.
Relebactam The excretion of Relebactam can be decreased when combined with Dinoprostone.
Tenofovir The excretion of Tenofovir can be decreased when combined with Dinoprostone.
Salicylic acid The excretion of Dinoprostone can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Dinoprostone can be decreased when combined with Acetylsalicylic acid.
Ketoprofen The excretion of Dinoprostone can be decreased when combined with Ketoprofen.
Minocycline The excretion of Dinoprostone can be decreased when combined with Minocycline.
Probenecid The excretion of Dinoprostone can be decreased when combined with Probenecid.
Ibuprofen The excretion of Dinoprostone can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Dinoprostone can be decreased when combined with Novobiocin.
Melatonin The excretion of Dinoprostone can be decreased when combined with Melatonin.
Ouabain The excretion of Dinoprostone can be decreased when combined with Ouabain.
Cefadroxil The excretion of Dinoprostone can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Dinoprostone can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Dinoprostone can be decreased when combined with Cefamandole.
Cefoperazone The excretion of Dinoprostone can be decreased when combined with Cefoperazone.
Liotrix The excretion of Dinoprostone can be decreased when combined with Liotrix.
Cilastatin The excretion of Dinoprostone can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Dinoprostone can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Dinoprostone can be decreased when combined with Topiroxostat.
Benzoic acid The excretion of Dinoprostone can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Dinoprostone can be decreased when combined with Caprylic acid.
Ataluren The excretion of Dinoprostone can be decreased when combined with Ataluren.
Teriflunomide The excretion of Dinoprostone can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Dinoprostone can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Dinoprostone can be decreased when combined with Dolutegravir.
Lenvatinib The excretion of Dinoprostone can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Dinoprostone can be decreased when combined with Cabotegravir.
Apalutamide The serum concentration of Dinoprostone can be decreased when it is combined with Apalutamide.
Letermovir The excretion of Dinoprostone can be decreased when combined with Letermovir.
Pradigastat The excretion of Dinoprostone can be decreased when combined with Pradigastat.
Enasidenib The excretion of Dinoprostone can be decreased when combined with Enasidenib.

Target Protein

Prostaglandin F2-alpha receptor PTGFR
Prostaglandin E2 receptor EP2 subtype PTGER2
Prostaglandin E2 receptor EP1 subtype PTGER1
Prostaglandin E2 receptor EP3 subtype PTGER3
Prostaglandin E2 receptor EP4 subtype PTGER4
Prostaglandin D2 receptor 2 PTGDR2

Referensi & Sumber

Synthesis reference: Yu-Wen Su, Meng-Hwan Lee, "Composition for inhibiting nitric oxide and/or prostaglandin E2 synthesis and method for inhibiting inflammation." U.S. Patent US20080268078, issued October 30, 2008.

Contoh Produk & Brand

Produk: 10 • International brands: 3
Produk
  • Cervidil
    Insert, extended release • 10 mg/1 • Vaginal • US • Approved
  • Cervidil
    Insert • 10 mg/241mg • Vaginal • US • Approved
  • Cervidil
    Insert • 10 mg / insert • Vaginal • Canada • Approved
  • Dinoprostone
    Insert • 10 mg/241mg • Vaginal • US • Approved
  • Prepidil
    Gel • 0.5 mg/3g • Vaginal • US • Approved
  • Prepidil Gel
    Gel • 0.5 mg / 2.5 mL • Endocervical • Canada • Approved
  • Prostin E2
    Suppository • 20 mg/1 • Vaginal • US • Approved
  • Prostin E2 Tablets
    Tablet • 0.5 mg • Oral • Canada • Approved
Menampilkan 8 dari 10 produk.
International Brands
  • Propess — Ferring Pharmaceuticals
  • Prostarmon E — DCPC
  • PROSTIN

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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