Peringatan Keamanan

Deaths have been reported from overdose with amantadine. The lowest reported acute lethal dose was 2 grams. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Pulmonary edema and respiratory distress (including ARDS) have been reported. Renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur. Central nervous system effects that have been reported include insomnia, anxiety, aggressive behavior, hypertonia, hyperkinesia, tremor, confusion, disorientation, depersonalization, fear, delirium, hallucination, psychotic reactions, lethargy, somnolence and coma. Seizures may be exacerbated in patients with prior history of seizure disorders. Hyperthermia has also been observed in cases where a drug overdose has occurred.

Amantadine

DB00915

small molecule approved

Deskripsi

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Struktur Molekul 2D

Berat 151.2487
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Mean half-lives ranged from 10 to 14 hours, however renal function impairment causes a severe increase in half life to 7 to 10 days.
Volume Distribusi * 3 to 8 L/kg [healthy subjects]
Klirens (Clearance) * 0.2 - 0.3 L/hr/kg * 0.10 +/- 0.04 L/hr/kg [healthy, elderly male]

Absorpsi

Amantadine is well absorbed orally from the gastrointestinal tract.

Metabolisme

No appreciable metabolism, although negligible amounts of an acetyl metabolite have been identified.

Rute Eliminasi

It is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

1451 Data
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Amantadine.
Methylphenidate The risk or severity of adverse effects can be increased when Methylphenidate is combined with Amantadine.
Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Amantadine.
Metoclopramide The therapeutic efficacy of Amantadine can be decreased when used in combination with Metoclopramide.
Bupropion The excretion of Amantadine can be decreased when combined with Bupropion.
Memantine The risk or severity of adverse effects can be increased when Amantadine is combined with Memantine.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Amantadine.
Glycopyrronium Amantadine may increase the anticholinergic activities of Glycopyrronium.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Amantadine is combined with Botulinum toxin type A.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Amantadine is combined with Botulinum toxin type B.
Mirtazapine Amantadine may increase the serotonergic activities of Mirtazapine.
Diamorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Diamorphine.
Desomorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Desomorphine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Amantadine is combined with Carfentanil, C-11.
Morphine The risk or severity of adverse effects can be increased when Amantadine is combined with Morphine.
Oxycodone The risk or severity of adverse effects can be increased when Amantadine is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Amantadine is combined with Butorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Amantadine is combined with Dextropropoxyphene.
Pentazocine The risk or severity of adverse effects can be increased when Amantadine is combined with Pentazocine.
Naltrexone The risk or severity of adverse effects can be increased when Amantadine is combined with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Amantadine is combined with Sufentanil.
Alfentanil The risk or severity of adverse effects can be increased when Amantadine is combined with Alfentanil.
Nalbuphine The risk or severity of adverse effects can be increased when Amantadine is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Amantadine is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Amantadine is combined with Remifentanil.
Buprenorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Buprenorphine.
Diphenoxylate The risk or severity of adverse effects can be increased when Amantadine is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Amantadine is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Amantadine is combined with Dezocine.
Levacetylmethadol The risk or severity of adverse effects can be increased when Amantadine is combined with Levacetylmethadol.
Methadyl acetate The risk or severity of adverse effects can be increased when Amantadine is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Dihydroetorphine.
Bezitramide The risk or severity of adverse effects can be increased when Amantadine is combined with Bezitramide.
Ethylmorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Amantadine is combined with Dextromoramide.
Carfentanil The risk or severity of adverse effects can be increased when Amantadine is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Amantadine is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Amantadine is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Dihydromorphine.
Tapentadol The risk or severity of serotonin syndrome can be increased when Amantadine is combined with Tapentadol.
Ketobemidone The risk or severity of adverse effects can be increased when Amantadine is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Amantadine is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Amantadine is combined with Lofentanil.
Normethadone The risk or severity of adverse effects can be increased when Amantadine is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Amantadine is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Amantadine is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Amantadine is combined with Nicomorphine.
Meptazinol The risk or severity of adverse effects can be increased when Amantadine is combined with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Amantadine is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Amantadine is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Amantadine is combined with Tilidine.
Hydromorphone The risk or severity of adverse effects can be increased when Amantadine is combined with Hydromorphone.
Methadone The risk or severity of adverse effects can be increased when Amantadine is combined with Methadone.
Opium The risk or severity of adverse effects can be increased when Amantadine is combined with Opium.
Codeine The risk or severity of adverse effects can be increased when Amantadine is combined with Codeine.
Meperidine The risk or severity of adverse effects can be increased when Amantadine is combined with Meperidine.
Fentanyl The risk or severity of adverse effects can be increased when Amantadine is combined with Fentanyl.
Benzhydrocodone The risk or severity of adverse effects can be increased when Amantadine is combined with Benzhydrocodone.
Naloxegol The risk or severity of adverse effects can be increased when Amantadine is combined with Naloxegol.
Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Amantadine.
Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Amantadine.
Butalbital The risk or severity of adverse effects can be increased when Butalbital is combined with Amantadine.
Talbutal The risk or severity of adverse effects can be increased when Talbutal is combined with Amantadine.
Ipratropium The risk or severity of adverse effects can be increased when Ipratropium is combined with Amantadine.
Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Amantadine.
Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Amantadine.
Oxyphencyclimine The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Amantadine.
Procyclidine The risk or severity of adverse effects can be increased when Procyclidine is combined with Amantadine.
Metocurine iodide The risk or severity of adverse effects can be increased when Metocurine iodide is combined with Amantadine.
Methscopolamine bromide The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Amantadine.
Metharbital The risk or severity of adverse effects can be increased when Metharbital is combined with Amantadine.
Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Amantadine.
Tridihexethyl The risk or severity of adverse effects can be increased when Tridihexethyl is combined with Amantadine.
Anisotropine methylbromide The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Amantadine.
Cisatracurium The risk or severity of adverse effects can be increased when Cisatracurium is combined with Amantadine.
Thiopental The risk or severity of adverse effects can be increased when Thiopental is combined with Amantadine.
Pirenzepine The risk or severity of adverse effects can be increased when Pirenzepine is combined with Amantadine.
Homatropine methylbromide The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Amantadine.
Atracurium besylate The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Amantadine.
Scopolamine The risk or severity of adverse effects can be increased when Scopolamine is combined with Amantadine.
Benzquinamide The risk or severity of adverse effects can be increased when Benzquinamide is combined with Amantadine.
Clidinium The risk or severity of adverse effects can be increased when Clidinium is combined with Amantadine.
Propiomazine The risk or severity of adverse effects can be increased when Propiomazine is combined with Amantadine.
Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Amantadine.
Tropicamide The risk or severity of adverse effects can be increased when Tropicamide is combined with Amantadine.
Biperiden The risk or severity of adverse effects can be increased when Biperiden is combined with Amantadine.
Methylphenobarbital The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Amantadine.
Methantheline The risk or severity of adverse effects can be increased when Amantadine is combined with Methantheline.
Cycrimine The risk or severity of adverse effects can be increased when Amantadine is combined with Cycrimine.
Cyclopentolate The risk or severity of adverse effects can be increased when Amantadine is combined with Cyclopentolate.
Oxybutynin The risk or severity of adverse effects can be increased when Amantadine is combined with Oxybutynin.
Pentolinium The risk or severity of adverse effects can be increased when Amantadine is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Amantadine is combined with Trimethaphan.
Phenobarbital The risk or severity of adverse effects can be increased when Amantadine is combined with Phenobarbital.
Mivacurium The risk or severity of adverse effects can be increased when Amantadine is combined with Mivacurium.
Diphenidol The risk or severity of adverse effects can be increased when Amantadine is combined with Diphenidol.
Fenoterol The risk or severity of adverse effects can be increased when Amantadine is combined with Fenoterol.
Metocurine The risk or severity of adverse effects can be increased when Amantadine is combined with Metocurine.
Vecuronium The risk or severity of adverse effects can be increased when Amantadine is combined with Vecuronium.

Target Protein

Matrix protein 2 M
Glutamate receptor ionotropic, NMDA 3A GRIN3A
D(2) dopamine receptor DRD2
Neuronal acetylcholine receptor subunit alpha-7 CHRNA7
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4
Neuronal acetylcholine receptor subunit alpha-3 CHRNA3

Referensi & Sumber

Synthesis reference: Haaf, W.; U.S. Patent 3,152,180; October 6, 1964; assigned to Studiengesellschaft Kohle mbH, Germany.

Contoh Produk & Brand

Produk: 127 • International brands: 4
Produk
  • Amantadine
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine
    Tablet • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine
    Tablet • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine
    Solution • 50 mg/5mL • Oral • US • Generic • Approved
  • Amantadine HCl
    Capsule • 100 mg/1 • Oral • US • Generic • Approved
  • Amantadine HCl
    Capsule, liquid filled • 100 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 127 produk.
International Brands
  • PK-Merz
  • Symadine
  • Viregyt
  • Virosol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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