Peringatan Keamanan

mptoms most often accompanying tiagabine overdose, alone or in combination with other drugs, have included: seizures including status epilepticus in patients with and without underlying seizure disorders, nonconvulsive status epilepticus, coma, ataxia, confusion, somnolence, drowsiness, impaired speech, agitation, lethargy, myoclonus, spike wave stupor, tremors, disorientation, vomiting, hostility, and temporary paralysis. Respiratory depression was seen in a number of patients, including children, in the context of seizures.

Tiagabine

DB00906

small molecule approved investigational

Deskripsi

Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.

Struktur Molekul 2D

Berat 375.548
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 7-9 hours
Volume Distribusi -
Klirens (Clearance) * 109 mL/min [Healthy subjects]

Absorpsi

Tiagabine is nearly completely absorbed (>95%).

Metabolisme

Tiagabine is likely metabolized primarily by the 3A isoform subfamily of hepatic cytochrome P450.

Rute Eliminasi

Approximately 2% of an oral dose of tiagabine is excreted unchanged, with 25% and 63% of the remaining dose excreted into the urine and feces, respectively, primarily as metabolites.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase drowsiness and dizziness.
  • 2. Take with food.

Interaksi Obat

921 Data
Buprenorphine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Hydrocodone Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Magnesium sulfate The therapeutic efficacy of Tiagabine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Tiagabine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Mirtazapine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Orphenadrine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Pramipexole Tiagabine may increase the sedative activities of Pramipexole.
Ropinirole Tiagabine may increase the sedative activities of Ropinirole.
Rotigotine Tiagabine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Tiagabine.
Sodium oxybate Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Thalidomide Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Mefloquine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Mefloquine.
Mianserin The therapeutic efficacy of Tiagabine can be decreased when used in combination with Mianserin.
Orlistat Orlistat can cause a decrease in the absorption of Tiagabine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Topotecan Tiagabine may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tiagabine.
Zidovudine The metabolism of Tiagabine can be increased when combined with Zidovudine.
Lamotrigine The metabolism of Tiagabine can be increased when combined with Lamotrigine.
Testosterone propionate The metabolism of Tiagabine can be increased when combined with Testosterone propionate.
Tetracosactide The risk or severity of liver damage can be increased when Tetracosactide is combined with Tiagabine.
Ethanol Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Fluvoxamine The risk or severity of adverse effects can be increased when Tiagabine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Tiagabine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Tiagabine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Tiagabine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Tiagabine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Tiagabine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Tiagabine is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Tiagabine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Tiagabine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Tiagabine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Tiagabine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Tiagabine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Tiagabine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Tiagabine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Tiagabine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Tiagabine is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Tiagabine.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Tiagabine.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Tiagabine.
Cocaine The risk or severity of methemoglobinemia can be increased when Tiagabine is combined with Cocaine.
Maprotiline The risk or severity of CNS depression can be increased when Tiagabine is combined with Maprotiline.
Desipramine The risk or severity of CNS depression can be increased when Tiagabine is combined with Desipramine.
Pizotifen The risk or severity of CNS depression can be increased when Tiagabine is combined with Pizotifen.
Dosulepin The risk or severity of CNS depression can be increased when Tiagabine is combined with Dosulepin.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Tiagabine.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Tiagabine.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Tiagabine.
Nicardipine The metabolism of Tiagabine can be decreased when combined with Nicardipine.
Quinidine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Quinidine.
Doxepin The risk or severity of CNS depression can be increased when Tiagabine is combined with Doxepin.
Quetiapine The risk or severity of CNS depression can be increased when Tiagabine is combined with Quetiapine.
Zopiclone The risk or severity of adverse effects can be increased when Tiagabine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Tiagabine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Tiagabine.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Tiagabine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Tiagabine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Tiagabine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Tiagabine.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Tiagabine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Tiagabine.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Tiagabine.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Tiagabine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Tiagabine.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Tiagabine.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Tiagabine.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Tiagabine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Tiagabine.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Tiagabine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Tiagabine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Tiagabine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Tiagabine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Tiagabine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Tiagabine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Tiagabine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Tiagabine.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Tiagabine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Tiagabine.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Tiagabine.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Tiagabine.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Tiagabine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Tiagabine.
Clozapine The metabolism of Tiagabine can be decreased when combined with Clozapine.
Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Tiagabine.

Target Protein

Sodium- and chloride-dependent GABA transporter 1 SLC6A1

Referensi & Sumber

Synthesis reference: Henning Petersen, Peter Nielsen, Michael Cain, Subhash Patel, "Crystalline Tiagabine monohydrate, its preparation and use." U.S. Patent US5354760, issued April, 1991.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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