Peringatan Keamanan

Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.

Methdilazine

DB00902

small molecule approved

Deskripsi

Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.

Struktur Molekul 2D

Berat 296.43
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed in the digestive tract.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

130 Data
Benzylpenicilloyl polylysine Methdilazine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Methdilazine.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Methdilazine.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Methdilazine.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Methdilazine.
Amphetamine Amphetamine may decrease the sedative activities of Methdilazine.
Phentermine Phentermine may decrease the sedative activities of Methdilazine.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Methdilazine.
Benzphetamine Benzphetamine may decrease the sedative activities of Methdilazine.
Diethylpropion Diethylpropion may decrease the sedative activities of Methdilazine.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Methdilazine.
Mephentermine Mephentermine may decrease the sedative activities of Methdilazine.
MMDA MMDA may decrease the sedative activities of Methdilazine.
Midomafetamine Midomafetamine may decrease the sedative activities of Methdilazine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Methdilazine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Methdilazine.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Methdilazine.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Methdilazine.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Methdilazine.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Methdilazine.
Metamfetamine Metamfetamine may decrease the sedative activities of Methdilazine.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Methdilazine.
Ritobegron Ritobegron may decrease the sedative activities of Methdilazine.
Mephedrone Mephedrone may decrease the sedative activities of Methdilazine.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Methdilazine.
Gepefrine Gepefrine may decrease the sedative activities of Methdilazine.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Methdilazine.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Methdilazine.
Pitolisant The therapeutic efficacy of Pitolisant can be decreased when used in combination with Methdilazine.
Lorazepam The therapeutic efficacy of Lorazepam can be decreased when used in combination with Methdilazine.
Pregabalin The therapeutic efficacy of Pregabalin can be decreased when used in combination with Methdilazine.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Methdilazine.
Phenytoin The therapeutic efficacy of Phenytoin can be decreased when used in combination with Methdilazine.
Topiramate The therapeutic efficacy of Topiramate can be decreased when used in combination with Methdilazine.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Methdilazine.
Valproic acid The therapeutic efficacy of Valproic acid can be decreased when used in combination with Methdilazine.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Methdilazine.
Clobazam The therapeutic efficacy of Clobazam can be decreased when used in combination with Methdilazine.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Methdilazine.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Methdilazine.
Methohexital The therapeutic efficacy of Methohexital can be decreased when used in combination with Methdilazine.
Mephenytoin The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Methdilazine.
Lamotrigine The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Methdilazine.
Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Methdilazine.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Methdilazine.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Methdilazine.
Paramethadione The therapeutic efficacy of Paramethadione can be decreased when used in combination with Methdilazine.
Clorazepic acid The therapeutic efficacy of Clorazepic acid can be decreased when used in combination with Methdilazine.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Methdilazine.
Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Methdilazine.
Riluzole The therapeutic efficacy of Riluzole can be decreased when used in combination with Methdilazine.
Ethotoin The therapeutic efficacy of Ethotoin can be decreased when used in combination with Methdilazine.
Oxcarbazepine The therapeutic efficacy of Oxcarbazepine can be decreased when used in combination with Methdilazine.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Methdilazine.
Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Methdilazine.
Diazepam The therapeutic efficacy of Diazepam can be decreased when used in combination with Methdilazine.
Phensuximide The therapeutic efficacy of Phensuximide can be decreased when used in combination with Methdilazine.
Progabide The therapeutic efficacy of Progabide can be decreased when used in combination with Methdilazine.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Methdilazine.
Tiagabine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Methdilazine.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Methdilazine.
Felbamate The therapeutic efficacy of Felbamate can be decreased when used in combination with Methdilazine.
Zaleplon The therapeutic efficacy of Zaleplon can be decreased when used in combination with Methdilazine.
Gabapentin The therapeutic efficacy of Gabapentin can be decreased when used in combination with Methdilazine.
Clonazepam The therapeutic efficacy of Clonazepam can be decreased when used in combination with Methdilazine.
Vigabatrin The therapeutic efficacy of Vigabatrin can be decreased when used in combination with Methdilazine.
Phenacemide The therapeutic efficacy of Phenacemide can be decreased when used in combination with Methdilazine.
Thiamylal The therapeutic efficacy of Thiamylal can be decreased when used in combination with Methdilazine.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Methdilazine.
Levetiracetam The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Methdilazine.
Estazolam The therapeutic efficacy of Estazolam can be decreased when used in combination with Methdilazine.
Fosphenytoin The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Methdilazine.
Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Methdilazine.
Hexobarbital The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Methdilazine.
Barbital The therapeutic efficacy of Barbital can be decreased when used in combination with Methdilazine.
Delorazepam The therapeutic efficacy of Delorazepam can be decreased when used in combination with Methdilazine.
Nitrazepam The therapeutic efficacy of Nitrazepam can be decreased when used in combination with Methdilazine.
7-Nitroindazole The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Methdilazine.
Valpromide The therapeutic efficacy of Valpromide can be decreased when used in combination with Methdilazine.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Methdilazine.
Ezogabine The therapeutic efficacy of Ezogabine can be decreased when used in combination with Methdilazine.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Methdilazine.
Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Methdilazine.
Rufinamide The therapeutic efficacy of Rufinamide can be decreased when used in combination with Methdilazine.
Lacosamide The therapeutic efficacy of Lacosamide can be decreased when used in combination with Methdilazine.
Remacemide The therapeutic efficacy of Remacemide can be decreased when used in combination with Methdilazine.
Clomethiazole The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Methdilazine.
Deramciclane The therapeutic efficacy of Deramciclane can be decreased when used in combination with Methdilazine.
Tramiprosate The therapeutic efficacy of Tramiprosate can be decreased when used in combination with Methdilazine.
Gaboxadol The therapeutic efficacy of Gaboxadol can be decreased when used in combination with Methdilazine.
Sulthiame The therapeutic efficacy of Sulthiame can be decreased when used in combination with Methdilazine.
Perampanel The therapeutic efficacy of Perampanel can be decreased when used in combination with Methdilazine.
Ifenprodil The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Methdilazine.
Barbexaclone The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Methdilazine.
Beclamide The therapeutic efficacy of Beclamide can be decreased when used in combination with Methdilazine.
Cannabidiol The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Methdilazine.
Paraldehyde The therapeutic efficacy of Paraldehyde can be decreased when used in combination with Methdilazine.
Stiripentol The therapeutic efficacy of Stiripentol can be decreased when used in combination with Methdilazine.
Eslicarbazepine acetate The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Methdilazine.
Doramectin The therapeutic efficacy of Doramectin can be decreased when used in combination with Methdilazine.

Target Protein

Histamine H1 receptor HRH1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15782943
    Rani Basu L, Mazumdar K, Dutta NK, Karak P, Dastidar SG: Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiol Res. 2005;160(1):95-100.
  • PMID: 9700532
    Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R: Altered membrane permeability as the basis of bactericidal action of methdilazine. J Antimicrob Chemother. 1998 Jul;42(1):83-6.
  • PMID: 2905130
    Chattopadhyay D, Dastidar SG, Chakrabarty AN: Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung. 1988 Jul;38(7):869-72.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Dilosyn
  • Tacaryl

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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