Bitolterol

DB00901

small molecule withdrawn

Deskripsi

Bitolterol mesylate was used to treat bronchospasms in asthma and COPD. It is a beta-2-adrenergic receptor agonist. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001.

Struktur Molekul 2D

Berat 461.5494
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

786 Data
Valsartan Bitolterol may decrease the antihypertensive activities of Valsartan.
Ramipril Bitolterol may decrease the antihypertensive activities of Ramipril.
Reserpine Bitolterol may decrease the antihypertensive activities of Reserpine.
Remikiren Bitolterol may decrease the antihypertensive activities of Remikiren.
Isradipine Bitolterol may decrease the antihypertensive activities of Isradipine.
Olmesartan Bitolterol may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Bitolterol may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Bitolterol may decrease the antihypertensive activities of Diltiazem.
Minoxidil Bitolterol may decrease the antihypertensive activities of Minoxidil.
Treprostinil Bitolterol may decrease the antihypertensive activities of Treprostinil.
Amlodipine Bitolterol may decrease the antihypertensive activities of Amlodipine.
Nimodipine Bitolterol may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Bitolterol may decrease the antihypertensive activities of Nisoldipine.
Fosinopril Bitolterol may decrease the antihypertensive activities of Fosinopril.
Trandolapril Bitolterol may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Bitolterol may decrease the antihypertensive activities of Lercanidipine.
Benazepril Bitolterol may decrease the antihypertensive activities of Benazepril.
Bosentan Bitolterol may decrease the antihypertensive activities of Bosentan.
Enalapril Bitolterol may decrease the antihypertensive activities of Enalapril.
Candoxatril Bitolterol may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Bitolterol may decrease the antihypertensive activities of Mecamylamine.
Losartan Bitolterol may decrease the antihypertensive activities of Losartan.
Moexipril Bitolterol may decrease the antihypertensive activities of Moexipril.
Eplerenone Bitolterol may decrease the antihypertensive activities of Eplerenone.
Lisinopril Bitolterol may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Bitolterol may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Bitolterol may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Bitolterol may decrease the antihypertensive activities of Cryptenamine.
Perindopril Bitolterol may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Bitolterol may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Bitolterol may decrease the antihypertensive activities of Fenoldopam.
Tadalafil Bitolterol may decrease the antihypertensive activities of Tadalafil.
Eprosartan Bitolterol may decrease the antihypertensive activities of Eprosartan.
Quinapril Bitolterol may decrease the antihypertensive activities of Quinapril.
Telmisartan Bitolterol may decrease the antihypertensive activities of Telmisartan.
Methyldopa Bitolterol may decrease the antihypertensive activities of Methyldopa.
Irbesartan Bitolterol may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Bitolterol may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Bitolterol may decrease the antihypertensive activities of Deserpidine.
Pentolinium Bitolterol may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Bitolterol may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Bitolterol may decrease the antihypertensive activities of Diazoxide.
Captopril Bitolterol may decrease the antihypertensive activities of Captopril.
Epoprostenol Bitolterol may decrease the antihypertensive activities of Epoprostenol.
Bepridil Bitolterol may decrease the antihypertensive activities of Bepridil.
Hydralazine Bitolterol may decrease the antihypertensive activities of Hydralazine.
Cilazapril Bitolterol may decrease the antihypertensive activities of Cilazapril.
Saprisartan Bitolterol may decrease the antihypertensive activities of Saprisartan.
Spirapril Bitolterol may decrease the antihypertensive activities of Spirapril.
Mibefradil Bitolterol may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Bitolterol may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Bitolterol may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Bitolterol may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Bitolterol may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Bitolterol may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Bitolterol may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Bitolterol may decrease the antihypertensive activities of Pinacidil.
Temocapril Bitolterol may decrease the antihypertensive activities of Temocapril.
Riociguat Bitolterol may decrease the antihypertensive activities of Riociguat.
Macitentan Bitolterol may decrease the antihypertensive activities of Macitentan.
Hexamethonium Bitolterol may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Bitolterol may decrease the antihypertensive activities of Aliskiren.
Nicorandil Bitolterol may decrease the antihypertensive activities of Nicorandil.
Efonidipine Bitolterol may decrease the antihypertensive activities of Efonidipine.
Lacidipine Bitolterol may decrease the antihypertensive activities of Lacidipine.
Manidipine Bitolterol may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Bitolterol may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Bitolterol may decrease the antihypertensive activities of Enalaprilat.
Selexipag Bitolterol may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Bitolterol may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Bitolterol may decrease the antihypertensive activities of Imidapril.
BQ-123 Bitolterol may decrease the antihypertensive activities of BQ-123.
Tetrahydropalmatine Bitolterol may decrease the antihypertensive activities of Tetrahydropalmatine.
Cicletanine Bitolterol may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Bitolterol may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Bitolterol may decrease the antihypertensive activities of Zofenopril.
Guanoxan Bitolterol may decrease the antihypertensive activities of Guanoxan.
Delapril Bitolterol may decrease the antihypertensive activities of Delapril.
Vincamine Bitolterol may decrease the antihypertensive activities of Vincamine.
Linsidomine Bitolterol may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Bitolterol may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Bitolterol may decrease the antihypertensive activities of Tolonidine.
Endralazine Bitolterol may decrease the antihypertensive activities of Endralazine.
Cadralazine Bitolterol may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Bitolterol may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Bitolterol may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Bitolterol may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Bitolterol may decrease the antihypertensive activities of Guanoclor.
Muzolimine Bitolterol may decrease the antihypertensive activities of Muzolimine.
Xipamide Bitolterol may decrease the antihypertensive activities of Xipamide.
Candesartan Bitolterol may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Bitolterol may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Bitolterol may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Bitolterol may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Bitolterol may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Bitolterol may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Bitolterol may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Bitolterol may decrease the antihypertensive activities of Quinaprilat.
Felodipine Bitolterol may decrease the antihypertensive activities of Felodipine.
Levamlodipine Bitolterol may decrease the antihypertensive activities of Levamlodipine.

Target Protein

Beta-3 adrenergic receptor ADRB3
Beta-2 adrenergic receptor ADRB2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 8564625
    Bierman CW, Kemp JP, Nathan RA: Efficacy and safety of inhaled bitolterol mesylate via metered-dose inhaler in children with asthma. Ann Allergy Asthma Immunol. 1996 Jan;76(1):27-35.
  • PMID: 3278878
    Friedel HA, Brogden RN: Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible obstructive airways disease. Drugs. 1988 Jan;35(1):22-41.
  • PMID: 8129213
    Nathan RA, Bronsky EA, Dockhorn RJ, Kemp JP: Multicenter dose-ranging study of bitolterol mesylate solution for nebulization in children with asthma. Ann Allergy. 1994 Mar;72(3):209-16.
  • PMID: 10155050
    Messina MS: Retrospective study of bitolterol mesylate in the treatment of conditions associated with reversible bronchospasm. Adv Ther. 1995 May-Jun;12(3):157-63.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Tornalate

Sekuens Gen/Protein (FASTA)

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