Peringatan Keamanan

Side effects include pancreatitis, peripheral neuropathy, diarrhea, hyperuricemia and hepatic dysfunction

Didanosine

DB00900

small molecule approved

Deskripsi

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.

Struktur Molekul 2D

Berat 236.2273
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 30 minutes in plasma and more than 12 hours in intracellular environment.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly absorbed (bioavailability 30-40%) with peak plasma concentrations appearing within 0.5 and 1.5 hrs.

Metabolisme

Rapidly metabolized intracellularly to its active moiety, 2,3-dideoxyadenosine-5-triphosphate (ddA-TP). It is then further metabolized hepatically to yield hypoxanthine, xanthine, and uric acid.

Rute Eliminasi

Based on data from in vitro and animal studies, it is presumed that the metabolism of didanosine in man occurs by the same pathways responsible for the elimination of endogenous purines. Purines are eliminated by the kidneys.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.

Interaksi Obat

960 Data
Fluconazole Didanosine can cause a decrease in the absorption of Fluconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Voriconazole Didanosine can cause a decrease in the absorption of Voriconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ketoconazole Didanosine can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Miconazole Didanosine can cause a decrease in the absorption of Miconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Didanosine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Posaconazole Didanosine can cause a decrease in the absorption of Posaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abafungin Didanosine can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ravuconazole Didanosine can cause a decrease in the absorption of Ravuconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albaconazole Didanosine can cause a decrease in the absorption of Albaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bifonazole Didanosine can cause a decrease in the absorption of Bifonazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Isavuconazole Didanosine can cause a decrease in the absorption of Isavuconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levoketoconazole Didanosine can cause a decrease in the absorption of Levoketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Moxifloxacin Didanosine can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Grepafloxacin Didanosine can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Didanosine can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Didanosine can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Didanosine can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Didanosine can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Didanosine can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Didanosine can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Didanosine can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Didanosine can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Didanosine can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Didanosine can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levofloxacin Didanosine can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Didanosine can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Didanosine can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Didanosine can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Didanosine can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Didanosine can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Didanosine can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Didanosine can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Didanosine can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Didanosine can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Didanosine can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Didanosine can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Didanosine can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Didanosine can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Didanosine can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Didanosine can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Didanosine can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Didanosine can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Didanosine can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Didanosine can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Didanosine can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Indinavir Didanosine can cause a decrease in the absorption of Indinavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tenofovir disoproxil The serum concentration of Didanosine can be increased when it is combined with Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Didanosine can be increased when it is combined with Tenofovir alafenamide.
Tenofovir The serum concentration of Didanosine can be increased when it is combined with Tenofovir.
Methadone The serum concentration of Didanosine can be decreased when it is combined with Methadone.
Allopurinol The serum concentration of Didanosine can be increased when it is combined with Allopurinol.
Stavudine The risk or severity of adverse effects can be increased when Stavudine is combined with Didanosine.
Ribavirin The serum concentration of dideoxyadenosine 5’-triphosphate, an active metabolite of Didanosine, can be increased when used in combination with Ribavirin.
Atazanavir The serum concentration of Atazanavir can be decreased when it is combined with Didanosine.
Darunavir The absorption of Didanosine can be decreased when combined with Darunavir.
Febuxostat The serum concentration of Didanosine can be increased when it is combined with Febuxostat.
Oxypurinol The serum concentration of Didanosine can be increased when it is combined with Oxypurinol.
Hydroxyurea The risk or severity of adverse effects can be increased when Hydroxyurea is combined with Didanosine.
Lopinavir The serum concentration of Didanosine can be decreased when it is combined with Lopinavir.
Tipranavir The serum concentration of Didanosine can be decreased when it is combined with Tipranavir.
Ganciclovir The risk or severity of cytopenia can be increased when Ganciclovir is combined with Didanosine.
Valganciclovir The risk or severity of cytopenia can be increased when Valganciclovir is combined with Didanosine.
Ethanol The risk or severity of adverse effects can be increased when Ethanol is combined with Didanosine.
Cyclosporine Cyclosporine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Didanosine which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Didanosine which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Didanosine which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Didanosine which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Didanosine which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Didanosine which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Didanosine which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Didanosine which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Didanosine which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Didanosine which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Didanosine which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Didanosine which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Didanosine which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Didanosine which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Didanosine which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Didanosine which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Didanosine which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Didanosine which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Didanosine which could result in a higher serum level.

Target Protein

Reverse transcriptase/RNaseH pol
Gag-Pol polyprotein gag-pol
Purine nucleoside phosphorylase PNP

Referensi & Sumber

Synthesis reference: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Rapolu Raji Reddy, Dasari Muralidhara Reddy, Kesireddy Subash Chander Reddy, "Novel Process for the Preparation of Didanosine Using Novel Intermediates." U.S. Patent US20080293938, issued November 27, 2008.

Contoh Produk & Brand

Produk: 40 • International brands: 0
Produk
  • Didanosine
    Capsule, delayed release pellets • 250 mg/1 • Oral • US • Generic • Approved
  • Didanosine
    Capsule, delayed release pellets • 400 mg/1 • Oral • US • Generic • Approved
  • Didanosine
    Capsule, delayed release pellets • 250 mg/1 • Oral • US • Generic • Approved
  • Didanosine
    Powder, for solution • 10 mg/1mL • Oral • US • Generic • Approved
  • Didanosine
    Powder, for solution • 10 mg/1mL • Oral • US • Generic • Approved
  • Didanosine
    Tablet, for suspension • 100 mg/1 • Oral • US • Generic • Approved
  • Didanosine
    Tablet, for suspension • 150 mg/1 • Oral • US • Generic • Approved
  • Didanosine
    Tablet, for suspension • 200 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 40 produk.

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