Remifentanil

DB00899

small molecule approved

Deskripsi

Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.

Struktur Molekul 2D

Berat 376.4467
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1-20 minutes
Volume Distribusi * 350 mL/kg * 452 ± 144 mL/kg [neonates] * 223 ± 30.6 mL/kg [adolescents]
Klirens (Clearance) * 40 mL/min/kg [young, healthy adults]

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases.

Rute Eliminasi

Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the sedative and CNS depressant effects of remifentanil.

Interaksi Obat

1359 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Remifentanil is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Remifentanil is combined with Levodopa.
Risperidone Remifentanil may increase the hypotensive activities of Risperidone.
Ceritinib Remifentanil may increase the bradycardic activities of Ceritinib.
Ivabradine Remifentanil may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Remifentanil.
Valsartan Remifentanil may decrease the antihypertensive activities of Valsartan.
Ramipril Remifentanil may decrease the antihypertensive activities of Ramipril.
Esmolol Remifentanil may decrease the antihypertensive activities of Esmolol.
Betaxolol Remifentanil may decrease the antihypertensive activities of Betaxolol.
Remikiren Remifentanil may decrease the antihypertensive activities of Remikiren.
Bethanidine Remifentanil may decrease the antihypertensive activities of Bethanidine.
Guanadrel Remifentanil may decrease the antihypertensive activities of Guanadrel.
Metoprolol Remifentanil may decrease the antihypertensive activities of Metoprolol.
Isradipine Remifentanil may decrease the antihypertensive activities of Isradipine.
Olmesartan Remifentanil may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Remifentanil may decrease the antihypertensive activities of Nitroprusside.
Atenolol Remifentanil may decrease the antihypertensive activities of Atenolol.
Diltiazem Remifentanil may decrease the antihypertensive activities of Diltiazem.
Minoxidil Remifentanil may decrease the antihypertensive activities of Minoxidil.
Timolol Remifentanil may decrease the antihypertensive activities of Timolol.
Treprostinil Remifentanil may decrease the antihypertensive activities of Treprostinil.
Amlodipine Remifentanil may decrease the antihypertensive activities of Amlodipine.
Nimodipine Remifentanil may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Remifentanil may decrease the antihypertensive activities of Nisoldipine.
Prazosin Remifentanil may decrease the antihypertensive activities of Prazosin.
Fosinopril Remifentanil may decrease the antihypertensive activities of Fosinopril.
Trandolapril Remifentanil may decrease the antihypertensive activities of Trandolapril.
Lercanidipine Remifentanil may decrease the antihypertensive activities of Lercanidipine.
Benazepril Remifentanil may decrease the antihypertensive activities of Benazepril.
Bosentan Remifentanil may decrease the antihypertensive activities of Bosentan.
Propranolol Remifentanil may decrease the antihypertensive activities of Propranolol.
Enalapril Remifentanil may decrease the antihypertensive activities of Enalapril.
Doxazosin Remifentanil may decrease the antihypertensive activities of Doxazosin.
Labetalol Remifentanil may decrease the antihypertensive activities of Labetalol.
Bisoprolol Remifentanil may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Remifentanil may decrease the antihypertensive activities of Candoxatril.
Guanabenz Remifentanil may decrease the antihypertensive activities of Guanabenz.
Losartan Remifentanil may decrease the antihypertensive activities of Losartan.
Moexipril Remifentanil may decrease the antihypertensive activities of Moexipril.
Phentolamine Remifentanil may decrease the antihypertensive activities of Phentolamine.
Lisinopril Remifentanil may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Remifentanil may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Remifentanil may decrease the antihypertensive activities of Cryptenamine.
Perindopril Remifentanil may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Remifentanil may decrease the antihypertensive activities of Candesartan cilexetil.
Tolazoline Remifentanil may decrease the antihypertensive activities of Tolazoline.
Fenoldopam Remifentanil may decrease the antihypertensive activities of Fenoldopam.
Tadalafil Remifentanil may decrease the antihypertensive activities of Tadalafil.
Eprosartan Remifentanil may decrease the antihypertensive activities of Eprosartan.
Quinapril Remifentanil may decrease the antihypertensive activities of Quinapril.
Omapatrilat Remifentanil may decrease the antihypertensive activities of Omapatrilat.
Phenoxybenzamine Remifentanil may decrease the antihypertensive activities of Phenoxybenzamine.
Telmisartan Remifentanil may decrease the antihypertensive activities of Telmisartan.
Methyldopa Remifentanil may decrease the antihypertensive activities of Methyldopa.
Felodipine Remifentanil may decrease the antihypertensive activities of Felodipine.
Irbesartan Remifentanil may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Remifentanil may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Remifentanil may decrease the antihypertensive activities of Deserpidine.
Carvedilol Remifentanil may decrease the antihypertensive activities of Carvedilol.
Bretylium Remifentanil may decrease the antihypertensive activities of Bretylium.
Terazosin Remifentanil may decrease the antihypertensive activities of Terazosin.
Guanethidine Remifentanil may decrease the antihypertensive activities of Guanethidine.
Rescinnamine Remifentanil may decrease the antihypertensive activities of Rescinnamine.
Acebutolol Remifentanil may decrease the antihypertensive activities of Acebutolol.
Captopril Remifentanil may decrease the antihypertensive activities of Captopril.
Nadolol Remifentanil may decrease the antihypertensive activities of Nadolol.
Epoprostenol Remifentanil may decrease the antihypertensive activities of Epoprostenol.
Bepridil Remifentanil may decrease the antihypertensive activities of Bepridil.
Hydralazine Remifentanil may decrease the antihypertensive activities of Hydralazine.
Bevantolol Remifentanil may decrease the antihypertensive activities of Bevantolol.
Practolol Remifentanil may decrease the antihypertensive activities of Practolol.
Cilazapril Remifentanil may decrease the antihypertensive activities of Cilazapril.
Saprisartan Remifentanil may decrease the antihypertensive activities of Saprisartan.
Spirapril Remifentanil may decrease the antihypertensive activities of Spirapril.
Mibefradil Remifentanil may decrease the antihypertensive activities of Mibefradil.
Dexpropranolol Remifentanil may decrease the antihypertensive activities of Dexpropranolol.
Debrisoquine Remifentanil may decrease the antihypertensive activities of Debrisoquine.
Celiprolol Remifentanil may decrease the antihypertensive activities of Celiprolol.
Nebivolol Remifentanil may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Remifentanil may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Remifentanil may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Remifentanil may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Remifentanil may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Remifentanil may decrease the antihypertensive activities of Pinacidil.
Bupranolol Remifentanil may decrease the antihypertensive activities of Bupranolol.
Temocapril Remifentanil may decrease the antihypertensive activities of Temocapril.
Riociguat Remifentanil may decrease the antihypertensive activities of Riociguat.
Macitentan Remifentanil may decrease the antihypertensive activities of Macitentan.
Indoramin Remifentanil may decrease the antihypertensive activities of Indoramin.
Indenolol Remifentanil may decrease the antihypertensive activities of Indenolol.
Aliskiren Remifentanil may decrease the antihypertensive activities of Aliskiren.
Trimazosin Remifentanil may decrease the antihypertensive activities of Trimazosin.
Manidipine Remifentanil may decrease the antihypertensive activities of Manidipine.
Niguldipine Remifentanil may decrease the antihypertensive activities of Niguldipine.
Moxonidine Remifentanil may decrease the antihypertensive activities of Moxonidine.
Rauwolfia serpentina root Remifentanil may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Remifentanil may decrease the antihypertensive activities of Enalaprilat.
Selexipag Remifentanil may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Remifentanil may decrease the antihypertensive activities of Angiotensin 1-7.

Target Protein

Mu-type opioid receptor OPRM1
Delta-type opioid receptor OPRD1
Kappa-type opioid receptor OPRK1

Referensi & Sumber

Synthesis reference: Jacob Mathew, J. Killgore, "New methods for the synthesis of alfentanil, sufentanil, and remifentanil." U.S. Patent US20060149071, issued July 06, 2006.

Contoh Produk & Brand

Produk: 32 • International brands: 0
Produk
  • Remifentanil for Injection
    Powder, for solution • 1 mg / vial • Intravenous • Canada • Approved
  • Remifentanil for Injection
    Powder, for solution • 2 mg / vial • Intravenous • Canada • Approved
  • Remifentanil for Injection
    Powder, for solution • 1 mg / vial • Intravenous • Canada • Approved
  • Remifentanil for Injection
    Powder, for solution • 2 mg / vial • Intravenous • Canada • Approved
  • Remifentanil Hydrochloride
    Injection, powder, lyophilized, for solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Remifentanil Hydrochloride
    Injection, powder, lyophilized, for solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Remifentanil Hydrochloride
    Injection, powder, lyophilized, for solution • 1 mg/1mL • Intravenous • US • Generic • Approved
  • Remifentanil Hydrochloride
    Injection, powder, lyophilized, for solution • 1 mg/1mL • Intravenous • US • Generic • Approved
Menampilkan 8 dari 32 produk.

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