Peringatan Keamanan

Symptoms of overdose include drowsiness, slurred speech, motor inco-ordination, coma, and respiratory depression.

Triazolam

DB00897

small molecule approved investigational

Deskripsi

Withdrawn in the United Kingdom due to risk of psychiatric adverse drug reactions. This drug continues to be available in the U.S. Internationally, triazolam is a Schedule IV drug under the Convention on Psychotropic Substances.

Struktur Molekul 2D

Berat 343.21
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1.5-5.5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Bioavailability is 44% (oral) and 53% (sublingual).

Metabolisme

Hepatic. Small amounts of unmetabolized triazolam appear in the urine.

Rute Eliminasi

Triazolam and its metabolites, principally as conjugated glucuronides, which are presumably inactive, are excreted primarily in the urine. Only small amounts of unmetabolized triazolam appear in the urine. The two primary metabolites accounted for 79.9% of urinary excretion.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Ingesting alcohol may increase the risk of complex behaviors like sleep-driving, which the patient does not remember.
  • 2. Avoid grapefruit products. Grapefruit may reduce the CYP3A4 metabolism of triazolam, which increases the serum concentration of triazolam.

Interaksi Obat

1633 Data
Buprenorphine Triazolam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Hydrocodone Triazolam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Magnesium sulfate The therapeutic efficacy of Triazolam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Triazolam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Triazolam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Mirtazapine Triazolam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Orphenadrine Triazolam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Triazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Pramipexole Triazolam may increase the sedative activities of Pramipexole.
Ropinirole Triazolam may increase the sedative activities of Ropinirole.
Rotigotine Triazolam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Triazolam.
Suvorexant Triazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Thalidomide Triazolam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Triazolam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Triazolam is combined with Clozapine.
Methadone Triazolam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Sodium oxybate Triazolam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Triazolam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Triazolam can be increased when used in combination with Yohimbine.
Erythromycin The serum concentration of Triazolam can be increased when it is combined with Erythromycin.
Sirolimus The serum concentration of Triazolam can be increased when it is combined with Sirolimus.
Dirithromycin The serum concentration of Triazolam can be increased when it is combined with Dirithromycin.
Telithromycin The serum concentration of Triazolam can be increased when it is combined with Telithromycin.
Candicidin The serum concentration of Triazolam can be increased when it is combined with Candicidin.
Clarithromycin The serum concentration of Triazolam can be increased when it is combined with Clarithromycin.
Josamycin The serum concentration of Triazolam can be increased when it is combined with Josamycin.
Everolimus The serum concentration of Triazolam can be increased when it is combined with Everolimus.
Epothilone D The serum concentration of Triazolam can be increased when it is combined with Epothilone D.
Patupilone The serum concentration of Triazolam can be increased when it is combined with Patupilone.
6-Deoxyerythronolide B The serum concentration of Triazolam can be increased when it is combined with 6-Deoxyerythronolide B.
Ixabepilone The serum concentration of Triazolam can be increased when it is combined with Ixabepilone.
KOS-1584 The serum concentration of Triazolam can be increased when it is combined with KOS-1584.
Ridaforolimus The serum concentration of Triazolam can be increased when it is combined with Ridaforolimus.
Temsirolimus The serum concentration of Triazolam can be increased when it is combined with Temsirolimus.
AVE9633 The serum concentration of Triazolam can be increased when it is combined with AVE9633.
Coltuximab ravtansine The serum concentration of Triazolam can be increased when it is combined with Coltuximab ravtansine.
Cethromycin The serum concentration of Triazolam can be increased when it is combined with Cethromycin.
Mitemcinal The serum concentration of Triazolam can be increased when it is combined with Mitemcinal.
Brefeldin A The serum concentration of Triazolam can be increased when it is combined with Brefeldin A.
Solithromycin The serum concentration of Triazolam can be increased when it is combined with Solithromycin.
Kitasamycin The serum concentration of Triazolam can be increased when it is combined with Kitasamycin.
Carbomycin The serum concentration of Triazolam can be increased when it is combined with Carbomycin.
Doramectin The serum concentration of Triazolam can be increased when it is combined with Doramectin.
Eprinomectin The serum concentration of Triazolam can be increased when it is combined with Eprinomectin.
Oleandomycin The serum concentration of Triazolam can be increased when it is combined with Oleandomycin.
Selamectin The serum concentration of Triazolam can be increased when it is combined with Selamectin.
Tildipirosin The serum concentration of Triazolam can be increased when it is combined with Tildipirosin.
Tilmicosin The serum concentration of Triazolam can be increased when it is combined with Tilmicosin.
Tylosin The serum concentration of Triazolam can be increased when it is combined with Tylosin.
Tylvalosin The serum concentration of Triazolam can be increased when it is combined with Tylvalosin.
Bryostatin 1 The serum concentration of Triazolam can be increased when it is combined with Bryostatin 1.
Lorvotuzumab mertansine The serum concentration of Triazolam can be increased when it is combined with Lorvotuzumab mertansine.
Epofolate The serum concentration of Triazolam can be increased when it is combined with Epofolate.
Sagopilone The serum concentration of Triazolam can be increased when it is combined with Sagopilone.
Troleandomycin The serum concentration of Triazolam can be increased when it is combined with Troleandomycin.
Miocamycin The serum concentration of Triazolam can be increased when it is combined with Miocamycin.
Flurithromycin The serum concentration of Triazolam can be increased when it is combined with Flurithromycin.
Rokitamycin The serum concentration of Triazolam can be increased when it is combined with Rokitamycin.
Midecamycin The serum concentration of Triazolam can be increased when it is combined with Midecamycin.
Clindamycin The serum concentration of Triazolam can be increased when it is combined with Clindamycin.
Mepartricin The serum concentration of Triazolam can be increased when it is combined with Mepartricin.
Flumazenil Flumazenil may decrease the sedative activities of Triazolam.
Saquinavir The serum concentration of Triazolam can be increased when it is combined with Saquinavir.
Itraconazole The metabolism of Triazolam can be decreased when combined with Itraconazole.
Simeprevir The serum concentration of Triazolam can be increased when it is combined with Simeprevir.
Ethanol Triazolam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Triazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
Trazodone The risk or severity of adverse effects can be increased when Triazolam is combined with Trazodone.
Sibutramine The risk or severity of adverse effects can be increased when Triazolam is combined with Sibutramine.
Escitalopram The risk or severity of adverse effects can be increased when Triazolam is combined with Escitalopram.
Levomilnacipran The risk or severity of adverse effects can be increased when Triazolam is combined with Levomilnacipran.
Ritanserin The risk or severity of adverse effects can be increased when Triazolam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Triazolam is combined with Alaproclate.
Fluvoxamine The risk or severity of adverse effects can be increased when Triazolam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Triazolam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Triazolam is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Triazolam is combined with Paroxetine.
Zimelidine The risk or severity of adverse effects can be increased when Triazolam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Triazolam is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Triazolam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Triazolam is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Triazolam is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Triazolam is combined with Indalpine.
Benzatropine Benzatropine may decrease the excretion rate of Triazolam which could result in a higher serum level.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Triazolam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Triazolam.
Propantheline Propantheline may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine may decrease the excretion rate of Triazolam which could result in a higher serum level.
Flavoxate Triazolam may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Aclidinium Triazolam may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Target Protein

Translocator protein TSPO
GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Artikel (PubMed)

Contoh Produk & Brand

Produk: 55 • International brands: 5
Produk
  • Alti-triazolam Tab 0.125mg
    Tablet • .125 mg / tab • Oral • Canada • Generic • Approved
  • Alti-triazolam Tab 0.25mg
    Tablet • .25 mg / tab • Oral • Canada • Generic • Approved
  • Halcion
    Tablet • 0.125 mg/1 • Oral • US • Approved
  • Halcion
    Tablet • 0.25 mg/1 • Oral • US • Approved
  • Halcion
    Tablet • .125 mg/1 • Oral • US • Approved
  • Halcion
    Tablet • 0.25 mg/1 • Oral • US • Approved
  • Halcion
    Tablet • 0.25 mg • Oral • Canada • Approved
  • Halcion
    Tablet • 0.125 mg • Oral • Canada • Approved
Menampilkan 8 dari 55 produk.
International Brands
  • Apo-Triazo — Apotex
  • Arring — YungShin
  • Asasion — Choseido Pharmaceutical Co., Ltd
  • Ascomarna — Nisshin Seiyaku K.K
  • Songar — Valeas S.p.A.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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