Peringatan Keamanan

Symptoms of overdose include retinal toxicity, glaucoma, and subcapsular cataract.

Rimexolone

DB00896

small molecule approved

Deskripsi

Rimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.

Struktur Molekul 2D

Berat 370.533
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The serum half-life of rimexolone could not be reliably estimated due to the large number of samples below the quantitation limit of the assay (80 pg/mL). However, based on the time required to reach steady-state, the half-life appears to be short (1-2 hours).
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Systemically absorbed.

Metabolisme

Undergoes extensive metabolism. Following intravenous administration of radiolabeled rimexolone in rats, more than 80% of the dose was excreted in the feces as rimexolone and metabolites. Metabolites have been shown to be either less active than rimexolone or inactive in human glucocorticoid receptor binding assays.

Rute Eliminasi

Following IV administration of radio-labelled rimexolone to rats, greater than 80% of the dose is excreted via the feces as rimexolone and metabolites.

Interaksi Obat

241 Data
Trastuzumab The risk or severity of neutropenia can be increased when Trastuzumab is combined with Rimexolone.
Tacrolimus Tacrolimus may increase the immunosuppressive activities of Rimexolone.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Rimexolone.
Lefamulin The metabolism of Lefamulin can be increased when combined with Rimexolone.
Elexacaftor The serum concentration of Elexacaftor can be decreased when it is combined with Rimexolone.
Phenylephrine The risk or severity of hypertension can be increased when Rimexolone is combined with Phenylephrine.
Aminoglutethimide The therapeutic efficacy of Rimexolone can be decreased when used in combination with Aminoglutethimide.
Insulin human The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin human.
Insulin lispro The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin lispro.
Insulin glargine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin glargine.
Insulin pork The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin pork.
Troglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Troglitazone.
Glimepiride The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glimepiride.
Sulfisoxazole The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Sulfisoxazole.
Disopyramide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Disopyramide.
Acarbose The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Acarbose.
Metformin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Metformin.
Sulfadiazine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Sulfadiazine.
Rosiglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Rosiglitazone.
Acetohexamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Acetohexamide.
Quinine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Quinine.
Miglitol The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Miglitol.
Chlorpropamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Chlorpropamide.
Nateglinide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Nateglinide.
Pentamidine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Pentamidine.
Mifepristone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Mifepristone.
Tolazamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Tolazamide.
Repaglinide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Repaglinide.
Phenformin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Phenformin.
Sulfamethoxazole The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Sulfamethoxazole.
Glyburide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glyburide.
Glipizide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glipizide.
Gliclazide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Gliclazide.
Tolbutamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Tolbutamide.
Pioglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Pioglitazone.
Bromocriptine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Bromocriptine.
Gliquidone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Gliquidone.
Mitiglinide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Mitiglinide.
Sitagliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Sitagliptin.
Sunitinib The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Sunitinib.
Exenatide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Exenatide.
Mecasermin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Mecasermin.
Pramlintide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Pramlintide.
Glisoxepide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glisoxepide.
Insulin aspart The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin aspart.
Insulin detemir The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin detemir.
Insulin glulisine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin glulisine.
Glymidine The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glymidine.
AICA ribonucleotide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with AICA ribonucleotide.
Buformin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Buformin.
Vildagliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Vildagliptin.
Voglibose The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Voglibose.
NN344 The risk or severity of hyperglycemia can be increased when Rimexolone is combined with NN344.
AMG-222 The risk or severity of hyperglycemia can be increased when Rimexolone is combined with AMG-222.
Bisegliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Bisegliptin.
Alogliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Alogliptin.
Dapagliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Dapagliflozin.
Saxagliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Saxagliptin.
Liraglutide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Liraglutide.
Gosogliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Gosogliptin.
Linagliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Linagliptin.
Canagliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Canagliflozin.
Glibornuride The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Glibornuride.
Benfluorex The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Benfluorex.
Empagliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Empagliflozin.
Albiglutide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Albiglutide.
Dulaglutide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Dulaglutide.
Lobeglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Lobeglitazone.
Netoglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Netoglitazone.
Rivoglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Rivoglitazone.
Ciglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Ciglitazone.
Lixisenatide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Lixisenatide.
Insulin beef The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin beef.
Insulin degludec The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin degludec.
Insulin peglispro The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin peglispro.
Insulin tregopil The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Insulin tregopil.
Ipragliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Ipragliflozin.
Dutogliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Dutogliptin.
Allicin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Allicin.
Tofogliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Tofogliflozin.
Ertugliflozin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Ertugliflozin.
2,4-thiazolidinedione The risk or severity of hyperglycemia can be increased when Rimexolone is combined with 2,4-thiazolidinedione.
Teneligliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Teneligliptin.
Omarigliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Omarigliptin.
Carmegliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Carmegliptin.
Gemigliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Gemigliptin.
Anagliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Anagliptin.
Evogliptin The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Evogliptin.
Sotagliflozin The serum concentration of Sotagliflozin can be decreased when it is combined with Rimexolone.
Balaglitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Balaglitazone.
Remogliflozin etabonate The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Remogliflozin etabonate.
Carbutamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Carbutamide.
Guar gum The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Guar gum.
Metahexamide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Metahexamide.
Semaglutide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Semaglutide.
Taspoglutide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Taspoglutide.
Englitazone The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Englitazone.
Tirzepatide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Tirzepatide.
Gastric inhibitory polypeptide The risk or severity of hyperglycemia can be increased when Rimexolone is combined with Gastric inhibitory polypeptide.
Isoniazid The serum concentration of Isoniazid can be decreased when it is combined with Rimexolone.

Target Protein

Glucocorticoid receptor NR3C1
Steroid hormone receptor ERR1 ESRRA

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Vexol
    Suspension / drops • 10 mg/1mL • Ophthalmic • US • Approved
  • Vexol Ophthalmic Suspension - 1%
    Suspension • 1 % • Ophthalmic • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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