Side effects include hyperkalemia, cough, hypotension, increased SrCr, and dizziness. Dizziness, diarrhea, vision disturbance, hypotension and angioedema
Omapatrilat is an investigational drug that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE). The inhibition of NEP elevates natriuretic peptide levels, increasing excretion of sodium in urine, dilating blood vessels, and reducing preload and ventricular remodeling. This drug from BMS was not approved by the FDA due to angioedema safety concerns.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Omapatrilat. |
| Amifostine | Omapatrilat may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Omapatrilat. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Omapatrilat. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Omapatrilat. |
| Obinutuzumab | Omapatrilat may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Omapatrilat. |
| Rituximab | Omapatrilat may increase the hypotensive activities of Rituximab. |
| Angiotensin 1-7 | Omapatrilat may decrease the antihypertensive activities of Angiotensin 1-7. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Omapatrilat. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Omapatrilat. |
| Siponimod | Siponimod may decrease the antihypertensive activities of Omapatrilat. |
| Reserpine | Omapatrilat may decrease the antihypertensive activities of Reserpine. |
| Torasemide | Omapatrilat may decrease the antihypertensive activities of Torasemide. |
| Nitroprusside | Omapatrilat may decrease the antihypertensive activities of Nitroprusside. |
| Minoxidil | Omapatrilat may decrease the antihypertensive activities of Minoxidil. |
| Clozapine | Clozapine may decrease the antihypertensive activities of Omapatrilat. |
| Imipramine | Imipramine may decrease the antihypertensive activities of Omapatrilat. |
| Chlorpromazine | Chlorpromazine may decrease the antihypertensive activities of Omapatrilat. |
| Doxazosin | Omapatrilat may decrease the antihypertensive activities of Doxazosin. |
| Dexmedetomidine | Dexmedetomidine may decrease the antihypertensive activities of Omapatrilat. |
| Mecamylamine | Omapatrilat may decrease the antihypertensive activities of Mecamylamine. |
| Thioridazine | Thioridazine may decrease the antihypertensive activities of Omapatrilat. |
| Phentolamine | Phentolamine may decrease the antihypertensive activities of Omapatrilat. |
| Sufentanil | Sufentanil may decrease the antihypertensive activities of Omapatrilat. |
| Nitroglycerin | Omapatrilat may decrease the antihypertensive activities of Nitroglycerin. |
| Isoflurane | Isoflurane may decrease the antihypertensive activities of Omapatrilat. |
| Tolazoline | Tolazoline may decrease the antihypertensive activities of Omapatrilat. |
| Fenoldopam | Omapatrilat may decrease the antihypertensive activities of Fenoldopam. |
| Propofol | Propofol may decrease the antihypertensive activities of Omapatrilat. |
| Remifentanil | Remifentanil may decrease the antihypertensive activities of Omapatrilat. |
| Phenoxybenzamine | Omapatrilat may decrease the antihypertensive activities of Phenoxybenzamine. |
| Methyldopa | Omapatrilat may decrease the antihypertensive activities of Methyldopa. |
| Guanfacine | Omapatrilat may decrease the antihypertensive activities of Guanfacine. |
| Bretylium | Omapatrilat may decrease the antihypertensive activities of Bretylium. |
| Halothane | Halothane may decrease the antihypertensive activities of Omapatrilat. |
| Terazosin | Omapatrilat may decrease the antihypertensive activities of Terazosin. |
| Desflurane | Desflurane may decrease the antihypertensive activities of Omapatrilat. |
| Bromocriptine | Bromocriptine may decrease the antihypertensive activities of Omapatrilat. |
| Sevoflurane | Sevoflurane may decrease the antihypertensive activities of Omapatrilat. |
| Clomipramine | Clomipramine may decrease the antihypertensive activities of Omapatrilat. |
| Hydralazine | Omapatrilat may decrease the antihypertensive activities of Hydralazine. |
| Lofexidine | Omapatrilat may decrease the antihypertensive activities of Lofexidine. |
| Rotigotine | Rotigotine may decrease the antihypertensive activities of Omapatrilat. |
| Riociguat | Omapatrilat may decrease the antihypertensive activities of Riociguat. |
| Isoxsuprine | Isoxsuprine may decrease the antihypertensive activities of Omapatrilat. |
| Indoramin | Omapatrilat may decrease the antihypertensive activities of Indoramin. |
| Moxonidine | Omapatrilat may decrease the antihypertensive activities of Moxonidine. |
| Selpercatinib | Selpercatinib may decrease the antihypertensive activities of Omapatrilat. |
| Naxitamab | Naxitamab may decrease the antihypertensive activities of Omapatrilat. |
| Levamlodipine | Omapatrilat may decrease the antihypertensive activities of Levamlodipine. |
| Amphetamine | Amphetamine may decrease the antihypertensive activities of Omapatrilat. |
| Aliskiren | The risk or severity of hypotension, hyperkalemia, and nephrotoxicity can be increased when Aliskiren is combined with Omapatrilat. |
| Allopurinol | The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Omapatrilat. |
| Aprotinin | Aprotinin may decrease the antihypertensive activities of Omapatrilat. |
| Azathioprine | The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Omapatrilat is combined with Azathioprine. |
| Ertugliflozin | The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Ertugliflozin is combined with Omapatrilat. |
| Canagliflozin | The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Canagliflozin is combined with Omapatrilat. |
| Dapagliflozin | The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Dapagliflozin is combined with Omapatrilat. |
| Empagliflozin | The risk or severity of renal failure, hypotension, and hyperkalemia can be increased when Empagliflozin is combined with Omapatrilat. |
| Dapoxetine | Dapoxetine may increase the orthostatic hypotensive activities of Omapatrilat. |
| Drospirenone | Omapatrilat may increase the hyperkalemic activities of Drospirenone. |
| Eplerenone | Eplerenone may increase the hyperkalemic activities of Omapatrilat. |
| Everolimus | The risk or severity of adverse effects can be increased when Everolimus is combined with Omapatrilat. |
| Sirolimus | The risk or severity of adverse effects can be increased when Sirolimus is combined with Omapatrilat. |
| Semuloparin | The risk or severity of hyperkalemia can be increased when Omapatrilat is combined with Semuloparin. |
| Icatibant | Icatibant may decrease the antihypertensive activities of Omapatrilat. |
| Lithium citrate | The serum concentration of Lithium citrate can be increased when it is combined with Omapatrilat. |
| Lithium carbonate | The serum concentration of Lithium carbonate can be increased when it is combined with Omapatrilat. |
| Lithium hydroxide | The serum concentration of Lithium hydroxide can be increased when it is combined with Omapatrilat. |
| Tizanidine | The risk or severity of hypotension can be increased when Tizanidine is combined with Omapatrilat. |
| Tolvaptan | Tolvaptan may increase the hyperkalemic activities of Omapatrilat. |
| Trimethoprim | Trimethoprim may increase the hyperkalemic activities of Omapatrilat. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Omapatrilat. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Omapatrilat. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Omapatrilat. |
| Eletriptan | Eletriptan may decrease the antihypertensive activities of Omapatrilat. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Omapatrilat. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Omapatrilat. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Omapatrilat. |
| Atomoxetine | Atomoxetine may decrease the antihypertensive activities of Omapatrilat. |
| Etomidate | Etomidate may decrease the antihypertensive activities of Omapatrilat. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Omapatrilat. |
| Dihydroergotamine | Dihydroergotamine may decrease the antihypertensive activities of Omapatrilat. |
| Amitriptyline | Amitriptyline may decrease the antihypertensive activities of Omapatrilat. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Omapatrilat. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Omapatrilat. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Omapatrilat. |
| Mirtazapine | Mirtazapine may decrease the antihypertensive activities of Omapatrilat. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Omapatrilat. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Omapatrilat. |
| Promazine | Promazine may decrease the antihypertensive activities of Omapatrilat. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Omapatrilat. |
| Buspirone | Buspirone may decrease the antihypertensive activities of Omapatrilat. |
| Nortriptyline | Nortriptyline may decrease the antihypertensive activities of Omapatrilat. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Omapatrilat. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Omapatrilat. |
| Atropine | Atropine may decrease the antihypertensive activities of Omapatrilat. |
| Lisuride | Lisuride may decrease the antihypertensive activities of Omapatrilat. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Omapatrilat. |