Peringatan Keamanan

Symptoms of overdose include reduced cardiac output and hypotension.

Isosorbide dinitrate

DB00883

small molecule approved investigational

Deskripsi

A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action.

Struktur Molekul 2D

Berat 236.1363
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 1 hour
Volume Distribusi * 2 to 4 L/kg
Klirens (Clearance) -

Absorpsi

Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.

Metabolisme

Hepatic

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food. Food decreases drug absorption.

Interaksi Obat

394 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Isosorbide dinitrate is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Isosorbide dinitrate is combined with Levodopa.
Risperidone Isosorbide dinitrate may increase the hypotensive activities of Risperidone.
Prilocaine The risk or severity of methemoglobinemia can be increased when Isosorbide dinitrate is combined with Prilocaine.
Dapoxetine Dapoxetine may increase the orthostatic hypotensive and hypotensive activities of Isosorbide dinitrate.
Riociguat Isosorbide dinitrate may increase the hypotensive activities of Riociguat.
Rosiglitazone The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Rosiglitazone.
Aripiprazole Aripiprazole may increase the hypotensive activities of Isosorbide dinitrate.
Aripiprazole lauroxil Aripiprazole lauroxil may increase the hypotensive activities of Isosorbide dinitrate.
Molsidomine Molsidomine may increase the hypotensive activities of Isosorbide dinitrate.
Nicorandil Nicorandil may increase the hypotensive activities of Isosorbide dinitrate.
Dipyridamole The risk or severity of hypotension can be increased when Dipyridamole is combined with Isosorbide dinitrate.
Ibudilast The risk or severity of hypotension can be increased when Ibudilast is combined with Isosorbide dinitrate.
Udenafil The risk or severity of hypotension can be increased when Udenafil is combined with Isosorbide dinitrate.
Doxofylline The risk or severity of hypotension can be increased when Doxofylline is combined with Isosorbide dinitrate.
Mirodenafil The risk or severity of hypotension can be increased when Mirodenafil is combined with Isosorbide dinitrate.
Fostamatinib The risk or severity of hypotension can be increased when Fostamatinib is combined with Isosorbide dinitrate.
Tadalafil The risk or severity of hypotension can be increased when Tadalafil is combined with Isosorbide dinitrate.
Vardenafil The risk or severity of hypotension can be increased when Vardenafil is combined with Isosorbide dinitrate.
Avanafil Avanafil may increase the hypotensive activities of Isosorbide dinitrate.
Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Isosorbide dinitrate.
Ethanol Ethanol may increase the hypotensive and vasodilatory activities of Isosorbide dinitrate.
Linezolid Linezolid may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Furazolidone Furazolidone may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Tranylcypromine Tranylcypromine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Phenelzine Phenelzine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Minaprine Minaprine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Selegiline Selegiline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Procarbazine Procarbazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Moclobemide Moclobemide may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Isocarboxazid Isocarboxazid may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Rasagiline Rasagiline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Pargyline Pargyline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Clorgiline Clorgiline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Iproniazid Iproniazid may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Nialamide Nialamide may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Safinamide Safinamide may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Methylene blue Methylene blue may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Hydracarbazine Hydracarbazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Pirlindole Pirlindole may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Toloxatone Toloxatone may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Benmoxin Benmoxin may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Mebanazine Mebanazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Octamoxin Octamoxin may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Pheniprazine Pheniprazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Phenoxypropazine Phenoxypropazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Pivhydrazine Pivhydrazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Safrazine Safrazine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Caroxazone Caroxazone may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Harmaline Harmaline may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Brofaromine Brofaromine may increase the orthostatic hypotensive activities of Isosorbide dinitrate.
Secobarbital Secobarbital may increase the hypotensive activities of Isosorbide dinitrate.
Methohexital Methohexital may increase the hypotensive activities of Isosorbide dinitrate.
Thiopental Thiopental may increase the hypotensive activities of Isosorbide dinitrate.
Methylphenobarbital Methylphenobarbital may increase the hypotensive activities of Isosorbide dinitrate.
Thiamylal Thiamylal may increase the hypotensive activities of Isosorbide dinitrate.
Amobarbital Amobarbital may increase the hypotensive activities of Isosorbide dinitrate.
Hexobarbital Hexobarbital may increase the hypotensive activities of Isosorbide dinitrate.
Barbital Barbital may increase the hypotensive activities of Isosorbide dinitrate.
Barbexaclone Barbexaclone may increase the hypotensive activities of Isosorbide dinitrate.
Pentobarbital Pentobarbital may increase the hypotensive activities of Isosorbide dinitrate.
Primidone Primidone may increase the hypotensive activities of Isosorbide dinitrate.
Butabarbital Butabarbital may increase the hypotensive activities of Isosorbide dinitrate.
Streptokinase The risk or severity of adverse effects can be increased when Streptokinase is combined with Isosorbide dinitrate.
Methyclothiazide The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Isosorbide dinitrate.
Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Isosorbide dinitrate.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Isosorbide dinitrate.
Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Isosorbide dinitrate.
Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Isosorbide dinitrate.
Triamterene The risk or severity of adverse effects can be increased when Triamterene is combined with Isosorbide dinitrate.
Pramipexole The risk or severity of adverse effects can be increased when Pramipexole is combined with Isosorbide dinitrate.
Spironolactone The risk or severity of adverse effects can be increased when Spironolactone is combined with Isosorbide dinitrate.
Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Isosorbide dinitrate.
Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Isosorbide dinitrate.
Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Isosorbide dinitrate.
Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Isosorbide dinitrate.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Isosorbide dinitrate.
Dexmedetomidine The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Isosorbide dinitrate.
Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Isosorbide dinitrate.
Furosemide The risk or severity of adverse effects can be increased when Furosemide is combined with Isosorbide dinitrate.
Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Isosorbide dinitrate.
Tamsulosin The risk or severity of adverse effects can be increased when Tamsulosin is combined with Isosorbide dinitrate.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Isosorbide dinitrate.
Apomorphine The risk or severity of adverse effects can be increased when Apomorphine is combined with Isosorbide dinitrate.
Mannitol The risk or severity of adverse effects can be increased when Mannitol is combined with Isosorbide dinitrate.
Propofol The risk or severity of adverse effects can be increased when Propofol is combined with Isosorbide dinitrate.
Bumetanide The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Bumetanide.
Remifentanil The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Remifentanil.
Etacrynic acid The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Etacrynic acid.
Levosimendan The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Levosimendan.
Levobupivacaine The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Levobupivacaine.
Thalidomide The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Thalidomide.
Iloprost Iloprost may increase the hypotensive activities of Isosorbide dinitrate.
Papaverine The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Papaverine.
Amifostine The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Amifostine.
Diclofenamide The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Diclofenamide.
Desflurane The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Desflurane.
Carbetocin The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Carbetocin.
Nesiritide The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Nesiritide.

Target Protein

Atrial natriuretic peptide receptor 1 NPR1

Referensi & Sumber

Synthesis reference: Gunter Cordes, Ulrich Munch, Ewald Giesselmann, "Supersaturated isosorbide dinitrate solution, process for its production and its use." U.S. Patent US4156736, issued August, 1976.

Contoh Produk & Brand

Produk: 191 • International brands: 6
Produk
  • BiDil
    Tablet, film coated • - • Oral • US • Approved
  • BiDil
    Tablet, film coated • - • Oral • US • Approved
  • BiDil
    Tablet, film coated • - • Oral • US • Approved
  • Cedocard-SR Srt 20mg
    Tablet, extended release • 20 mg • Oral • Canada • Approved
  • Cedocard-SR Srt 40mg
    Tablet, extended release • 40 mg • Oral • Canada • Approved
  • Coradur Tab 20mg
    Tablet, extended release • 20 mg • Oral • Canada • Approved
  • Coronex
    Tablet • 10 mg • Oral • Canada • Approved
  • Coronex
    Tablet • 30 mg • Oral • Canada • Approved
Menampilkan 8 dari 191 produk.
International Brands
  • Carvasin — Ayerst
  • Flindix — Vitória
  • Isoket — Schwarz
  • Isorbid — Armstrong
  • Nitrosorbide — Lusofarmaco
  • Sorbidilat — Actavis

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul