Peringatan Keamanan

The acute oral LD50 of clomifene is 1700 mg/kg in mice and 5750 mg/kg in rats. The toxic dose in humans is not known. Toxic effects accompanying acute overdosage of clomifene have not been reported. Signs and symptoms of overdosage as a result of the use of more than the recommended dose during clomifene therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain.

Clomifene

DB00882

small molecule approved investigational

Deskripsi

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Struktur Molekul 2D

Berat 405.96
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 5-7 days
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Based on early studies with 14 C-labeled clomifene, the drug was shown to be readily absorbed orally in humans.

Metabolisme

Hepatic

Rute Eliminasi

Based on early studies with 14C-labeled clomiphene citrate, the drug was shown to be readily absorbed orally in humans and excreted principally in the feces. Mean urinary excretion was approximately 8% with fecal excretion of about 42%.

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

238 Data
Ranolazine The serum concentration of Clomifene can be increased when it is combined with Ranolazine.
Ospemifene The risk or severity of adverse effects can be increased when Clomifene is combined with Ospemifene.
Lumacaftor The serum concentration of Clomifene can be decreased when it is combined with Lumacaftor.
Vemurafenib The serum concentration of Clomifene can be increased when it is combined with Vemurafenib.
Apalutamide The serum concentration of Clomifene can be decreased when it is combined with Apalutamide.
Pitolisant The serum concentration of Clomifene can be increased when it is combined with Pitolisant.
Isavuconazole The serum concentration of Clomifene can be increased when it is combined with Isavuconazole.
Isavuconazonium The serum concentration of Clomifene can be increased when it is combined with Isavuconazonium.
Amiodarone The serum concentration of Clomifene can be increased when it is combined with Amiodarone.
Quinidine The serum concentration of Clomifene can be increased when it is combined with Quinidine.
Fluconazole The serum concentration of Clomifene can be increased when it is combined with Fluconazole.
Erythromycin The serum concentration of Clomifene can be increased when it is combined with Erythromycin.
Sildenafil The serum concentration of Clomifene can be increased when it is combined with Sildenafil.
Reserpine The serum concentration of Clomifene can be increased when it is combined with Reserpine.
Sorafenib The serum concentration of Clomifene can be increased when it is combined with Sorafenib.
Loxapine The serum concentration of Clomifene can be increased when it is combined with Loxapine.
Quinine The serum concentration of Clomifene can be increased when it is combined with Quinine.
Ritonavir The serum concentration of Clomifene can be increased when it is combined with Ritonavir.
Toremifene The serum concentration of Clomifene can be increased when it is combined with Toremifene.
Verapamil The serum concentration of Clomifene can be increased when it is combined with Verapamil.
Tamoxifen The serum concentration of Clomifene can be increased when it is combined with Tamoxifen.
Mifepristone The serum concentration of Clomifene can be increased when it is combined with Mifepristone.
Vardenafil The serum concentration of Clomifene can be increased when it is combined with Vardenafil.
Tacrolimus The serum concentration of Clomifene can be increased when it is combined with Tacrolimus.
Conivaptan The serum concentration of Clomifene can be increased when it is combined with Conivaptan.
Zonisamide The serum concentration of Clomifene can be increased when it is combined with Zonisamide.
Tipranavir The serum concentration of Clomifene can be increased when it is combined with Tipranavir.
Ketoconazole The serum concentration of Clomifene can be increased when it is combined with Ketoconazole.
Carvedilol The serum concentration of Clomifene can be increased when it is combined with Carvedilol.
Itraconazole The serum concentration of Clomifene can be increased when it is combined with Itraconazole.
Propafenone The serum concentration of Clomifene can be increased when it is combined with Propafenone.
Clarithromycin The serum concentration of Clomifene can be increased when it is combined with Clarithromycin.
Saquinavir The serum concentration of Clomifene can be increased when it is combined with Saquinavir.
Lapatinib The serum concentration of Clomifene can be increased when it is combined with Lapatinib.
Paliperidone The serum concentration of Clomifene can be increased when it is combined with Paliperidone.
Mibefradil The serum concentration of Clomifene can be increased when it is combined with Mibefradil.
Lopinavir The serum concentration of Clomifene can be increased when it is combined with Lopinavir.
Biricodar The serum concentration of Clomifene can be increased when it is combined with Biricodar.
Dronedarone The serum concentration of Clomifene can be increased when it is combined with Dronedarone.
Nilotinib The serum concentration of Clomifene can be increased when it is combined with Nilotinib.
Elacridar The serum concentration of Clomifene can be increased when it is combined with Elacridar.
Flibanserin The serum concentration of Clomifene can be increased when it is combined with Flibanserin.
Vandetanib The serum concentration of Clomifene can be increased when it is combined with Vandetanib.
Telaprevir The serum concentration of Clomifene can be increased when it is combined with Telaprevir.
Zosuquidar The serum concentration of Clomifene can be increased when it is combined with Zosuquidar.
Tariquidar The serum concentration of Clomifene can be increased when it is combined with Tariquidar.
Temsirolimus The serum concentration of Clomifene can be increased when it is combined with Temsirolimus.
Simeprevir The serum concentration of Clomifene can be increased when it is combined with Simeprevir.
Brefeldin A The serum concentration of Clomifene can be increased when it is combined with Brefeldin A.
Ticagrelor The serum concentration of Clomifene can be increased when it is combined with Ticagrelor.
Ivacaftor The serum concentration of Clomifene can be increased when it is combined with Ivacaftor.
Lomitapide The serum concentration of Clomifene can be increased when it is combined with Lomitapide.
Crizotinib The serum concentration of Clomifene can be increased when it is combined with Crizotinib.
Linagliptin The serum concentration of Clomifene can be increased when it is combined with Linagliptin.
Regorafenib The serum concentration of Clomifene can be increased when it is combined with Regorafenib.
Ponatinib The serum concentration of Clomifene can be increased when it is combined with Ponatinib.
Canagliflozin The serum concentration of Clomifene can be increased when it is combined with Canagliflozin.
Afatinib The serum concentration of Clomifene can be increased when it is combined with Afatinib.
Ledipasvir The serum concentration of Clomifene can be increased when it is combined with Ledipasvir.
Vorapaxar The serum concentration of Clomifene can be increased when it is combined with Vorapaxar.
Suvorexant The serum concentration of Clomifene can be increased when it is combined with Suvorexant.
Netupitant The serum concentration of Clomifene can be increased when it is combined with Netupitant.
Cobicistat The serum concentration of Clomifene can be increased when it is combined with Cobicistat.
Palbociclib The serum concentration of Clomifene can be increased when it is combined with Palbociclib.
Daclatasvir The serum concentration of Clomifene can be increased when it is combined with Daclatasvir.
Niguldipine The serum concentration of Clomifene can be increased when it is combined with Niguldipine.
Rolapitant The serum concentration of Clomifene can be increased when it is combined with Rolapitant.
Venetoclax The serum concentration of Clomifene can be increased when it is combined with Venetoclax.
Velpatasvir The serum concentration of Clomifene can be increased when it is combined with Velpatasvir.
Neratinib The serum concentration of Clomifene can be increased when it is combined with Neratinib.
Valspodar The serum concentration of Clomifene can be increased when it is combined with Valspodar.
Dacomitinib The serum concentration of Clomifene can be increased when it is combined with Dacomitinib.
Glasdegib The serum concentration of Clomifene can be increased when it is combined with Glasdegib.
Voxilaprevir The serum concentration of Clomifene can be increased when it is combined with Voxilaprevir.
Sarecycline The serum concentration of Clomifene can be increased when it is combined with Sarecycline.
Laniquidar The serum concentration of Clomifene can be increased when it is combined with Laniquidar.
Enasidenib The serum concentration of Clomifene can be increased when it is combined with Enasidenib.
Pibrentasvir The serum concentration of Clomifene can be increased when it is combined with Pibrentasvir.
Glecaprevir The serum concentration of Clomifene can be increased when it is combined with Glecaprevir.
Dexniguldipine The serum concentration of Clomifene can be increased when it is combined with Dexniguldipine.
ONT-093 The serum concentration of Clomifene can be increased when it is combined with ONT-093.
Entrectinib The serum concentration of Clomifene can be increased when it is combined with Entrectinib.
Fedratinib The serum concentration of Clomifene can be increased when it is combined with Fedratinib.
Istradefylline The serum concentration of Clomifene can be increased when it is combined with Istradefylline.
Norgestimate The serum concentration of Clomifene can be increased when it is combined with Norgestimate.
Carfilzomib The serum concentration of Clomifene can be increased when it is combined with Carfilzomib.
Asunaprevir The serum concentration of Clomifene can be increased when it is combined with Asunaprevir.
Favipiravir The serum concentration of Clomifene can be increased when it is combined with Favipiravir.
Methylene blue The serum concentration of Clomifene can be increased when it is combined with Methylene blue.
Ripretinib The serum concentration of Clomifene can be increased when it is combined with Ripretinib.
Pralsetinib The serum concentration of Clomifene can be increased when it is combined with Pralsetinib.
Lonafarnib The serum concentration of Clomifene can be increased when it is combined with Lonafarnib.
Clofazimine The serum concentration of Clomifene can be increased when it is combined with Clofazimine.
Arsenic trioxide The serum concentration of Clomifene can be increased when it is combined with Arsenic trioxide.
Mefloquine The serum concentration of Clomifene can be increased when it is combined with Mefloquine.
Cethromycin The serum concentration of Clomifene can be increased when it is combined with Cethromycin.
Ixabepilone The serum concentration of Clomifene can be increased when it is combined with Ixabepilone.
Voclosporin The serum concentration of Clomifene can be increased when it is combined with Voclosporin.
Eliglustat The serum concentration of Clomifene can be increased when it is combined with Eliglustat.
Umbralisib The serum concentration of Clomifene can be increased when it is combined with Umbralisib.

Target Protein

Estrogen receptor ESR1
Sex hormone-binding globulin SHBG

Referensi & Sumber

Synthesis reference: Allen, R.E., Palopoli, F.P., Schumann, E.L. and Van Carnpen, M.G. Jr.; US. Patent 2,914,563; November 24, 1959; assigned to The Wrn. S. Merrell Company.
Artikel (PubMed)
  • PMID: 7710399
    Purvin VA: Visual disturbance secondary to clomiphene citrate. Arch Ophthalmol. 1995 Apr;113(4):482-4.
  • PMID: 14585326
    Hayon T, Atlas L, Levy E, Dvilansky A, Shpilberg O, Nathan I: Multifactorial activities of nonsteroidal antiestrogens against leukemia. Cancer Detect Prev. 2003;27(5):389-96.
  • PMID: 1906682
    Fritz MA, Holmes RT, Keenan EJ: Effect of clomiphene citrate treatment on endometrial estrogen and progesterone receptor induction in women. Am J Obstet Gynecol. 1991 Jul;165(1):177-85.
  • PMID: 20091498
    Hughes E, Brown J, Collins JJ, Vanderkerchove P: Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD000057. doi: 10.1002/14651858.CD000057.pub2.
  • PMID: 19821295
    Brown J, Farquhar C, Beck J, Boothroyd C, Hughes E: Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD002249. doi: 10.1002/14651858.CD002249.pub4.
  • PMID: 17055820
    Authors unspecified: Use of clomiphene citrate in women. Fertil Steril. 2006 Nov;86(5 Suppl 1):S187-93.
  • PMID: 18320435
    Homburg R: Oral agents for ovulation induction--clomiphene citrate versus aromatase inhibitors. Hum Fertil (Camb). 2008 Mar;11(1):17-22. doi: 10.1080/14647270701689670.
  • PMID: 15878925
    Homburg R: Clomiphene citrate--end of an era? A mini-review. Hum Reprod. 2005 Aug;20(8):2043-51. Epub 2005 May 5.

Contoh Produk & Brand

Produk: 27 • International brands: 4
Produk
  • Clomid
    Tablet • 50 mg/1 • Oral • US • Approved
  • Clomid
    Tablet • 50 mg • Oral • Canada • Approved
  • Clomid
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Clomid
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Clomid 50mg
    Tablet • 50 mg / tab • Oral • Canada • Approved
  • Clomiphene Citrate
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Clomiphene Citrate
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
  • Clomiphene Citrate
    Tablet • 50 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 27 produk.
International Brands
  • Androxal
  • Clomifert
  • Clostilbegyt — Egis
  • Omifin — Sanofi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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