Oral, rat LD50: > 10 g/kg. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Chlorothiazide is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Chlorothiazide is combined with Levodopa. |
| Risperidone | Chlorothiazide may increase the hypotensive activities of Risperidone. |
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Chlorothiazide. |
| Amifostine | Chlorothiazide may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Chlorothiazide. |
| Forasartan | Chlorothiazide may increase the hypotensive and Electrolyte Disturbance activities of Forasartan. |
| Tasosartan | Chlorothiazide may increase the hypotensive and Electrolyte Disturbance activities of Tasosartan. |
| Saralasin | Chlorothiazide may increase the hypotensive and Electrolyte Disturbance activities of Saralasin. |
| Fimasartan | Chlorothiazide may increase the hypotensive and Electrolyte Disturbance activities of Fimasartan. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Chlorothiazide. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Chlorothiazide. |
| Obinutuzumab | Chlorothiazide may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Chlorothiazide. |
| Rituximab | Chlorothiazide may increase the hypotensive activities of Rituximab. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Chlorothiazide. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Chlorothiazide. |
| Eletriptan | Eletriptan may decrease the antihypertensive activities of Chlorothiazide. |
| Methysergide | Methysergide may decrease the antihypertensive activities of Chlorothiazide. |
| Cabergoline | Cabergoline may decrease the antihypertensive activities of Chlorothiazide. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Chlorothiazide. |
| Dihydroergotamine | Dihydroergotamine may decrease the antihypertensive activities of Chlorothiazide. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Chlorothiazide. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Chlorothiazide. |
| Mirtazapine | Mirtazapine may decrease the antihypertensive activities of Chlorothiazide. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Chlorothiazide. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Chlorothiazide. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Chlorothiazide. |
| Lisuride | Lisuride may decrease the antihypertensive activities of Chlorothiazide. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Chlorothiazide. |
| Ergotamine | Ergotamine may decrease the antihypertensive activities of Chlorothiazide. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Chlorothiazide. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Chlorothiazide. |
| Trimipramine | Trimipramine may decrease the antihypertensive activities of Chlorothiazide. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Chlorothiazide. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Chlorothiazide. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Chlorothiazide. |
| Benzphetamine | Benzphetamine may decrease the antihypertensive activities of Chlorothiazide. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Chlorothiazide. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Chlorothiazide. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Chlorothiazide. |
| Methoxyflurane | Methoxyflurane may decrease the antihypertensive activities of Chlorothiazide. |
| Ergoloid mesylate | Ergoloid mesylate may decrease the antihypertensive activities of Chlorothiazide. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Chlorothiazide. |
| Propafenone | Propafenone may decrease the antihypertensive activities of Chlorothiazide. |
| Pergolide | Pergolide may decrease the antihypertensive activities of Chlorothiazide. |
| Finasteride | Finasteride may decrease the antihypertensive activities of Chlorothiazide. |
| Ergometrine | Ergometrine may decrease the antihypertensive activities of Chlorothiazide. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Chlorothiazide. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Chlorothiazide. |
| Yohimbine | Yohimbine may decrease the antihypertensive activities of Chlorothiazide. |
| MMDA | MMDA may decrease the antihypertensive activities of Chlorothiazide. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Chlorothiazide. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Chlorothiazide. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Chlorothiazide. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Chlorothiazide. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Chlorothiazide. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Chlorothiazide. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Chlorothiazide. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Chlorothiazide. |
| Periciazine | Periciazine may decrease the antihypertensive activities of Chlorothiazide. |
| Acepromazine | Acepromazine may decrease the antihypertensive activities of Chlorothiazide. |
| Thioproperazine | Thioproperazine may decrease the antihypertensive activities of Chlorothiazide. |
| Zuclopenthixol | Zuclopenthixol may decrease the antihypertensive activities of Chlorothiazide. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Chlorothiazide. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Chlorothiazide. |
| Lysergic acid diethylamide | Lysergic acid diethylamide may decrease the antihypertensive activities of Chlorothiazide. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Chlorothiazide. |
| Dronedarone | Dronedarone may decrease the antihypertensive activities of Chlorothiazide. |
| Flibanserin | Flibanserin may decrease the antihypertensive activities of Chlorothiazide. |
| Iloperidone | Iloperidone may decrease the antihypertensive activities of Chlorothiazide. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Chlorothiazide. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Chlorothiazide. |
| Cariprazine | Cariprazine may decrease the antihypertensive activities of Chlorothiazide. |
| Mianserin | Mianserin may decrease the antihypertensive activities of Chlorothiazide. |
| Nylidrin | Nylidrin may decrease the antihypertensive activities of Chlorothiazide. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Chlorothiazide. |
| Asenapine | Asenapine may decrease the antihypertensive activities of Chlorothiazide. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Chlorothiazide. |
| Vilazodone | Vilazodone may decrease the antihypertensive activities of Chlorothiazide. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Chlorothiazide. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Chlorothiazide. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Chlorothiazide. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Chlorothiazide. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Chlorothiazide. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Chlorothiazide. |
| Lurasidone | Lurasidone may decrease the antihypertensive activities of Chlorothiazide. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Chlorothiazide. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Chlorothiazide. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Chlorothiazide. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Chlorothiazide. |
| Butriptyline | Butriptyline may decrease the antihypertensive activities of Chlorothiazide. |
| Cannabidiol | Cannabidiol may decrease the antihypertensive activities of Chlorothiazide. |
| Brexpiprazole | Brexpiprazole may decrease the antihypertensive activities of Chlorothiazide. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Chlorothiazide. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Chlorothiazide. |
| Tianeptine | Tianeptine may decrease the antihypertensive activities of Chlorothiazide. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Chlorothiazide. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Chlorothiazide. |
| Dihydroergocornine | Dihydroergocornine may decrease the antihypertensive activities of Chlorothiazide. |