Oral LD50 in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include drowsiness, nausea, vomiting, diarrhea, hyperventilation, tachycardia, sweating, tinnitus, disorientation, stupor, and coma. As a monotherapy, the smallest dosage capable of causing death was reported as 15 grams.
Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of diflunisal. Short-term use does not appear to be associated with increased cardiovascular risk (except when used immediately following coronary artery bypass graft (CABG) surgery). Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Severe hepatic reactions, including cholestasis and/or jaundice, have been reported. May cause rash or hypersensitivity syndrome.
Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Amlodipine | Diflunisal may decrease the antihypertensive activities of Amlodipine. |
| Phentermine | The risk or severity of hypertension can be increased when Phentermine is combined with Diflunisal. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Diflunisal. |
| Eletriptan | The risk or severity of hypertension can be increased when Eletriptan is combined with Diflunisal. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Diflunisal. |
| Ziprasidone | The risk or severity of hypertension can be increased when Ziprasidone is combined with Diflunisal. |
| Methysergide | The risk or severity of hypertension can be increased when Methysergide is combined with Diflunisal. |
| Cabergoline | The risk or severity of hypertension can be increased when Cabergoline is combined with Diflunisal. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Diflunisal. |
| Dihydroergotamine | The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Diflunisal. |
| Methylergometrine | The risk or severity of hypertension can be increased when Methylergometrine is combined with Diflunisal. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Diflunisal. |
| Mirtazapine | The risk or severity of hypertension can be increased when Mirtazapine is combined with Diflunisal. |
| Phenylephrine | The risk or severity of hypertension can be increased when Phenylephrine is combined with Diflunisal. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Diflunisal. |
| Promazine | The risk or severity of hypertension can be increased when Promazine is combined with Diflunisal. |
| Droperidol | The risk or severity of hypertension can be increased when Droperidol is combined with Diflunisal. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Diflunisal. |
| Atropine | The risk or severity of hypertension can be increased when Atropine is combined with Diflunisal. |
| Lisuride | The risk or severity of hypertension can be increased when Lisuride is combined with Diflunisal. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Diflunisal. |
| Metaraminol | The risk or severity of hypertension can be increased when Metaraminol is combined with Diflunisal. |
| Furazolidone | The risk or severity of hypertension can be increased when Furazolidone is combined with Diflunisal. |
| Epinephrine | The risk or severity of hypertension can be increased when Epinephrine is combined with Diflunisal. |
| Thioridazine | The risk or severity of hypertension can be increased when Thioridazine is combined with Diflunisal. |
| Ergotamine | The risk or severity of hypertension can be increased when Ergotamine is combined with Diflunisal. |
| Nicergoline | The risk or severity of hypertension can be increased when Nicergoline is combined with Diflunisal. |
| Sufentanil | The risk or severity of hypertension can be increased when Sufentanil is combined with Diflunisal. |
| Methoxamine | The risk or severity of hypertension can be increased when Methoxamine is combined with Diflunisal. |
| Risperidone | The risk or severity of hypertension can be increased when Risperidone is combined with Diflunisal. |
| Tranylcypromine | The risk or severity of hypertension can be increased when Tranylcypromine is combined with Diflunisal. |
| Isoflurane | The risk or severity of hypertension can be increased when Isoflurane is combined with Diflunisal. |
| Propiomazine | The risk or severity of hypertension can be increased when Propiomazine is combined with Diflunisal. |
| Alfentanil | The risk or severity of hypertension can be increased when Alfentanil is combined with Diflunisal. |
| Minaprine | The risk or severity of hypertension can be increased when Minaprine is combined with Diflunisal. |
| Orciprenaline | The risk or severity of hypertension can be increased when Orciprenaline is combined with Diflunisal. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Phenmetrazine is combined with Diflunisal. |
| Trifluoperazine | The risk or severity of hypertension can be increased when Trifluoperazine is combined with Diflunisal. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Diflunisal. |
| Benzphetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Benzphetamine. |
| Ritodrine | The risk or severity of hypertension can be increased when Diflunisal is combined with Ritodrine. |
| Flupentixol | The risk or severity of hypertension can be increased when Diflunisal is combined with Flupentixol. |
| Remifentanil | The risk or severity of hypertension can be increased when Diflunisal is combined with Remifentanil. |
| Bitolterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Bitolterol. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Diflunisal is combined with Oxymetazoline. |
| Diethylpropion | The risk or severity of hypertension can be increased when Diflunisal is combined with Diethylpropion. |
| Salmeterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Salmeterol. |
| Naratriptan | The risk or severity of hypertension can be increased when Diflunisal is combined with Naratriptan. |
| Frovatriptan | The risk or severity of hypertension can be increased when Diflunisal is combined with Frovatriptan. |
| Methoxyflurane | The risk or severity of hypertension can be increased when Diflunisal is combined with Methoxyflurane. |
| Selegiline | The risk or severity of hypertension can be increased when Diflunisal is combined with Selegiline. |
| Ergoloid mesylate | The risk or severity of hypertension can be increased when Diflunisal is combined with Ergoloid mesylate. |
| Isoprenaline | The risk or severity of hypertension can be increased when Diflunisal is combined with Isoprenaline. |
| Arbutamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Arbutamine. |
| Dutasteride | The risk or severity of hypertension can be increased when Diflunisal is combined with Dutasteride. |
| Halothane | The risk or severity of hypertension can be increased when Diflunisal is combined with Halothane. |
| Moclobemide | The risk or severity of hypertension can be increased when Diflunisal is combined with Moclobemide. |
| Pergolide | The risk or severity of hypertension can be increased when Diflunisal is combined with Pergolide. |
| Desflurane | The risk or severity of hypertension can be increased when Diflunisal is combined with Desflurane. |
| Finasteride | The risk or severity of hypertension can be increased when Diflunisal is combined with Finasteride. |
| Aripiprazole | The risk or severity of hypertension can be increased when Diflunisal is combined with Aripiprazole. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Diflunisal is combined with Isocarboxazid. |
| Ergometrine | The risk or severity of hypertension can be increased when Diflunisal is combined with Ergometrine. |
| Lisdexamfetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Lisdexamfetamine. |
| Fenoterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Fenoterol. |
| Pirbuterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Pirbuterol. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Diflunisal is combined with Ephedra sinica root. |
| Ephedrine | The risk or severity of hypertension can be increased when Diflunisal is combined with Ephedrine. |
| Mephentermine | The risk or severity of hypertension can be increased when Diflunisal is combined with Mephentermine. |
| Procaterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Procaterol. |
| Yohimbine | The risk or severity of hypertension can be increased when Diflunisal is combined with Yohimbine. |
| Methotrimeprazine | The risk or severity of hypertension can be increased when Diflunisal is combined with Methotrimeprazine. |
| Clenbuterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Clenbuterol. |
| Bambuterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Bambuterol. |
| MMDA | The risk or severity of hypertension can be increased when Diflunisal is combined with MMDA. |
| Midomafetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Midomafetamine. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with 2,5-Dimethoxy-4-ethylamphetamine. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with 4-Methoxyamphetamine. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with 4-Bromo-2,5-dimethoxyamphetamine. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Tenamfetamine. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Diflunisal is combined with Chlorphentermine. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Diflunisal is combined with Dextroamphetamine. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Diflunisal is combined with Phendimetrazine. |
| Solifenacin | The risk or severity of hypertension can be increased when Diflunisal is combined with Solifenacin. |
| Periciazine | The risk or severity of hypertension can be increased when Diflunisal is combined with Periciazine. |
| Acepromazine | The risk or severity of hypertension can be increased when Diflunisal is combined with Acepromazine. |
| Thioproperazine | The risk or severity of hypertension can be increased when Diflunisal is combined with Thioproperazine. |
| Zuclopenthixol | The risk or severity of hypertension can be increased when Diflunisal is combined with Zuclopenthixol. |
| Epicaptopril | The risk or severity of hypertension can be increased when Diflunisal is combined with Epicaptopril. |
| Clorgiline | The risk or severity of hypertension can be increased when Diflunisal is combined with Clorgiline. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when Diflunisal is combined with 1-benzylimidazole. |
| Iproniazid | The risk or severity of hypertension can be increased when Diflunisal is combined with Iproniazid. |
| Nialamide | The risk or severity of hypertension can be increased when Diflunisal is combined with Nialamide. |
| Lysergic acid diethylamide | The risk or severity of hypertension can be increased when Diflunisal is combined with Lysergic acid diethylamide. |
| Dronedarone | The risk or severity of hypertension can be increased when Diflunisal is combined with Dronedarone. |
| Flibanserin | The risk or severity of hypertension can be increased when Diflunisal is combined with Flibanserin. |
| Iloperidone | The risk or severity of hypertension can be increased when Diflunisal is combined with Iloperidone. |
| Indacaterol | The risk or severity of hypertension can be increased when Diflunisal is combined with Indacaterol. |
| Rotigotine | The risk or severity of hypertension can be increased when Diflunisal is combined with Rotigotine. |
| Amibegron | The risk or severity of hypertension can be increased when Diflunisal is combined with Amibegron. |