Peringatan Keamanan

The intraperitoneal LD50 in rats is 2g/kg and 65mg/kg in mice.L9545 The subcutaneous LD50 in rats is 147mg/kg and >3500mg/kg in mice.L9545 The oral LD50 in mice is 1680mg/kg.L9545 In humans, the oral TDLO in men is 9mg/kg/2W and in women is 14mg/kg/13D.L9545

Patients experiencing an overdose of prednisolone may present with gastrointestinal disturbances, insomnia, and restlessness.A187511 Overdose of oral prednisolone may be treated by gastric lavage or inducing vomiting if the overdose was recent, as well as supportive and symptomatic therapy.L9449 Chronic overdosage may be treated by dose reduction or treating patients on alternate days.L9449 An overdose by the ophthalmic route is not expected to cause problems.L9449

Prednisolone

DB00860

small molecule approved vet_approved

Deskripsi

Prednisolone is a glucocorticoid similar to cortisol used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.A187463

Prednisolone was granted FDA approval on 21 June 1955.L9431

Struktur Molekul 2D

Berat 360.444
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Prednisolone has a plasma half life of 2.1-3.5 hours.[A187394] This half life is shorter in children and longer in those with liver disease.[A187394]
Volume Distribusi A 0.15mg/kg dose of prednisolone has a volume of distribution of 29.3L, while a 0.30mg/kg dose has a volume of distribution of 44.2L.[A187394]
Klirens (Clearance) A 0.15mg/kg dose of prednisolone has a clearance of 0.09L/kg/h, while a 0.30mg/kg dose has a clearance of 0.12L/kg/h.[A187394]

Absorpsi

Oral prednisolone reaches a Cmax of 113-1343ng/mL with a Tmax of 1.0-2.6 hours.A187394 Oral prednisolone is approximately 70% bioavailable.A187400

Metabolisme

Prednisolone can be reversibly metabolized to prednisone which is then metabolized to 17?,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII), 20?-dihydro-prednisone (M-V), 6?hydroxy-prednisone (M-XII), 6?-hydroxy-prednisone (M-XIII), or 20?-dihydro-prednisone (M-IV).A187403 20?-dihydro-prednisone is metabolized to 17?,20?,21-trihydroxy-5?-pregn-1-en-3,11-dione(M-XVIII).A187403 Prednisolone is metabolized to ?6-prednisolone (M-XI), 20?-dihydro-prednisolone (M-III), 20?-dihydro-prednisolone (M-II), 6?hydroxy-prednisolone (M-VII), or 6?hydroxy-prednisolone(M-VI).A187403 6?hydroxy-prednisolone is metabolized to 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-X).A187403 6?hydroxy-prednisolone is metabolized to 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-VIII), 6?,11?,17?,20?,21-pentahydroxypregnan-1,4-diene-3-one (M-IX), and 6?,11?,17?,21-tetrahydroxy-5?-pregn-1-en-3,20-dione (M-XIV).A187403 MVIII is metabolized to 6?,11?,17?,20?,21-pentahydroxy-5?-pregn-1-en-3-one (M-XV) and then to MXIV, while MIX is metabolized to 6?,11?,17?,20?,21-pentahydroxy-5?-pregn-1-en-3-one (M-XVI) and then to MXIV.A187403 These metabolites and their glucuronide conjugates are excreted predominantly in the urine.A187403

Rute Eliminasi

Prednisolone is over 98% eliminated in urine.A187394

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food. Food reduces irritation.

Interaksi Obat

1172 Data
Denosumab The risk or severity of adverse effects can be increased when Denosumab is combined with Prednisolone.
Peginterferon alfa-2a The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Prednisolone.
Interferon alfa-n1 The risk or severity of adverse effects can be increased when Interferon alfa-n1 is combined with Prednisolone.
Interferon alfa-n3 The risk or severity of adverse effects can be increased when Interferon alfa-n3 is combined with Prednisolone.
Peginterferon alfa-2b The risk or severity of adverse effects can be increased when Peginterferon alfa-2b is combined with Prednisolone.
Interferon gamma-1b The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Prednisolone.
Interferon alfa-2a The risk or severity of adverse effects can be increased when Interferon alfa-2a is combined with Prednisolone.
Aldesleukin The risk or severity of adverse effects can be increased when Aldesleukin is combined with Prednisolone.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Prednisolone.
Pegaspargase The risk or severity of adverse effects can be increased when Pegaspargase is combined with Prednisolone.
Interferon beta-1b The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Prednisolone.
Interferon alfacon-1 The risk or severity of adverse effects can be increased when Interferon alfacon-1 is combined with Prednisolone.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Prednisolone.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Prednisolone.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Prednisolone.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Prednisolone.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Prednisolone.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Prednisolone.
Alefacept The risk or severity of adverse effects can be increased when Alefacept is combined with Prednisolone.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Prednisolone.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Prednisolone.
Interferon alfa-2b The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Prednisolone.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Prednisolone.
Phenylalanine The risk or severity of adverse effects can be increased when Phenylalanine is combined with Prednisolone.
Cladribine Prednisolone may increase the immunosuppressive activities of Cladribine.
Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Prednisolone.
Amsacrine The risk or severity of adverse effects can be increased when Amsacrine is combined with Prednisolone.
Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Prednisolone.
Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Prednisolone.
Raltitrexed The risk or severity of adverse effects can be increased when Raltitrexed is combined with Prednisolone.
Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Prednisolone.
Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Prednisolone.
Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Prednisolone.
Tioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Prednisolone.
Dexrazoxane The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Prednisolone.
Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Prednisolone.
Trifluridine The risk or severity of adverse effects can be increased when Trifluridine is combined with Prednisolone.
Gemcitabine The risk or severity of adverse effects can be increased when Gemcitabine is combined with Prednisolone.
Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Prednisolone.
Chloramphenicol The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Prednisolone.
Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Prednisolone.
Altretamine The risk or severity of adverse effects can be increased when Altretamine is combined with Prednisolone.
Zidovudine The risk or severity of adverse effects can be increased when Zidovudine is combined with Prednisolone.
Oxaliplatin The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Prednisolone.
Fluorouracil The risk or severity of adverse effects can be increased when Fluorouracil is combined with Prednisolone.
Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Prednisolone.
Pentostatin The risk or severity of adverse effects can be increased when Pentostatin is combined with Prednisolone.
Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Prednisolone.
Clofarabine The risk or severity of adverse effects can be increased when Clofarabine is combined with Prednisolone.
Pemetrexed The risk or severity of adverse effects can be increased when Pemetrexed is combined with Prednisolone.
Mycophenolate mofetil The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Prednisolone.
Dacarbazine The risk or severity of adverse effects can be increased when Dacarbazine is combined with Prednisolone.
Temozolomide The risk or severity of adverse effects can be increased when Temozolomide is combined with Prednisolone.
Penicillamine The risk or severity of adverse effects can be increased when Penicillamine is combined with Prednisolone.
Azacitidine The risk or severity of adverse effects can be increased when Prednisolone is combined with Azacitidine.
Carboplatin The risk or severity of adverse effects can be increased when Prednisolone is combined with Carboplatin.
Dactinomycin The risk or severity of adverse effects can be increased when Prednisolone is combined with Dactinomycin.
Azathioprine The risk or severity of adverse effects can be increased when Prednisolone is combined with Azathioprine.
Hydroxyurea The risk or severity of adverse effects can be increased when Prednisolone is combined with Hydroxyurea.
Mycophenolic acid The risk or severity of adverse effects can be increased when Prednisolone is combined with Mycophenolic acid.
Topotecan The risk or severity of adverse effects can be increased when Prednisolone is combined with Topotecan.
Mercaptopurine The risk or severity of adverse effects can be increased when Prednisolone is combined with Mercaptopurine.
Thalidomide The risk or severity of adverse effects can be increased when Prednisolone is combined with Thalidomide.
Melphalan The risk or severity of adverse effects can be increased when Prednisolone is combined with Melphalan.
Fludarabine The risk or severity of adverse effects can be increased when Prednisolone is combined with Fludarabine.
Flucytosine The risk or severity of adverse effects can be increased when Prednisolone is combined with Flucytosine.
Capecitabine The risk or severity of adverse effects can be increased when Prednisolone is combined with Capecitabine.
Procarbazine The risk or severity of adverse effects can be increased when Prednisolone is combined with Procarbazine.
Arsenic trioxide The risk or severity of adverse effects can be increased when Prednisolone is combined with Arsenic trioxide.
Idarubicin The risk or severity of adverse effects can be increased when Prednisolone is combined with Idarubicin.
Estramustine The risk or severity of adverse effects can be increased when Prednisolone is combined with Estramustine.
Mitoxantrone The risk or severity of adverse effects can be increased when Prednisolone is combined with Mitoxantrone.
Lomustine The risk or severity of adverse effects can be increased when Prednisolone is combined with Lomustine.
Eculizumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Eculizumab.
Decitabine The risk or severity of adverse effects can be increased when Prednisolone is combined with Decitabine.
Nelarabine The risk or severity of adverse effects can be increased when Prednisolone is combined with Nelarabine.
Stepronin The risk or severity of adverse effects can be increased when Prednisolone is combined with Stepronin.
Hydroxychloroquine The risk or severity of adverse effects can be increased when Prednisolone is combined with Hydroxychloroquine.
Castanospermine The risk or severity of adverse effects can be increased when Prednisolone is combined with Castanospermine.
Vorinostat The risk or severity of adverse effects can be increased when Prednisolone is combined with Vorinostat.
2-Methoxyethanol The risk or severity of adverse effects can be increased when Prednisolone is combined with 2-Methoxyethanol.
Brequinar The risk or severity of adverse effects can be increased when Prednisolone is combined with Brequinar.
Pirfenidone The risk or severity of adverse effects can be increased when Prednisolone is combined with Pirfenidone.
Interferon alfa The risk or severity of adverse effects can be increased when Prednisolone is combined with Interferon alfa.
Glatiramer The risk or severity of adverse effects can be increased when Prednisolone is combined with Glatiramer.
Briakinumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Briakinumab.
Human interferon omega-1 The risk or severity of adverse effects can be increased when Prednisolone is combined with Human interferon omega-1.
Mepolizumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Mepolizumab.
Abetimus The risk or severity of adverse effects can be increased when Prednisolone is combined with Abetimus.
Belatacept The risk or severity of adverse effects can be increased when Prednisolone is combined with Belatacept.
Bendamustine The risk or severity of adverse effects can be increased when Prednisolone is combined with Bendamustine.
Pralatrexate The risk or severity of adverse effects can be increased when Prednisolone is combined with Pralatrexate.
Wortmannin The risk or severity of adverse effects can be increased when Prednisolone is combined with Wortmannin.
Eribulin The risk or severity of adverse effects can be increased when Prednisolone is combined with Eribulin.
Belimumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Belimumab.
Teriflunomide The risk or severity of adverse effects can be increased when Prednisolone is combined with Teriflunomide.
Carfilzomib The risk or severity of adverse effects can be increased when Prednisolone is combined with Carfilzomib.
Dimethyl fumarate The risk or severity of adverse effects can be increased when Prednisolone is combined with Dimethyl fumarate.
Obinutuzumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Obinutuzumab.
Vedolizumab The risk or severity of adverse effects can be increased when Prednisolone is combined with Vedolizumab.

Target Protein

Glucocorticoid receptor NR3C1

Referensi & Sumber

Synthesis reference: Gunther Bellmann, "Process for producing a sterile prednisolone gel." U.S. Patent US5811417, issued September 22, 1998.
Artikel (PubMed)
  • PMID: 378499
    Pickup ME: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1979 Mar-Apr;4(2):111-28. doi: 10.2165/00003088-197904020-00004.
  • PMID: 3350994
    Ferry JJ, Horvath AM, Bekersky I, Heath EC, Ryan CF, Colburn WA: Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses. J Clin Pharmacol. 1988 Jan;28(1):81-7. doi: 10.1002/j.1552-4604.1988.tb03105.x.
  • PMID: 25800201
    Matabosch X, Pozo OJ, Perez-Mana C, Papaseit E, Segura J, Ventura R: Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571.
  • PMID: 30285357
    Yasir M, Sonthalia S: Corticosteroid Adverse Effects .
  • PMID: 27789930
    Robinson J, McKenzie C, MacLeod D: Paediatric dosing errors with oral prednisolone mixture. Aust Prescr. 2016 Oct;39(5):176. doi: 10.18773/austprescr.2016.062. Epub 2016 Oct 1.

Contoh Produk & Brand

Produk: 43 • International brands: 17
Produk
  • Cambison
    Ointment • - • Topical • US • OTC
  • Millipred
    Tablet • 5 mg/5mg • Oral • US • Generic • Approved
  • Millipred
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Millipred
    Tablet • 5 mg/1 • Oral • US • Generic • Approved
  • Novo-prednisolone 5mg
    Tablet • 5 mg • Oral • Canada • Generic • Approved
  • Prednisolone
    Tablet • 5 mg/1 • Oral • US • Approved
  • Prednisolone
    Syrup • 15 mg/5mL • Oral • US • Generic • Approved
  • Prednisolone
    Syrup • 5 mg/5mL • Oral • US • Generic • Approved
Menampilkan 8 dari 43 produk.
International Brands
  • Ak-Pred
  • Decortin H
  • Delta-Cortef
  • Deltacortril
  • Hydeltra
  • Hydeltra-TBA
  • Hydeltrasol
  • Inflamase
  • Key-Pred
  • Klismacort

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