Peringatan Keamanan

Symptoms of a chlorphenesin overdose include drowsiness and nausea.

Chlorphenesin

DB00856

small molecule approved experimental

Deskripsi

Struktur Molekul 2D

Berat 202.635
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.3-5 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapid and complete.

Metabolisme

Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

28 Data
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Chlorphenesin.
Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Chlorphenesin.
Metoclopramide The risk or severity of sedation can be increased when Metoclopramide is combined with Chlorphenesin.
Lasmiditan The risk or severity of adverse effects can be increased when Lasmiditan is combined with Chlorphenesin.
Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Chlorphenesin.
Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Chlorphenesin.
Ranolazine The metabolism of Ranolazine can be increased when combined with Chlorphenesin.
Tramadol The risk or severity of CNS depression can be increased when Chlorphenesin is combined with Tramadol.
Clindamycin The metabolism of Clindamycin can be increased when combined with Chlorphenesin.
Ziprasidone The risk or severity of adverse effects can be increased when Chlorphenesin is combined with Ziprasidone.
Rimegepant The metabolism of Rimegepant can be increased when combined with Chlorphenesin.
Haloperidol The risk or severity of CNS depression can be increased when Haloperidol is combined with Chlorphenesin.
Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Chlorphenesin.
Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Chlorphenesin.
Fluoxetine Chlorphenesin may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Oliceridine The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Chlorphenesin is combined with Oliceridine.
Tivozanib The metabolism of Tivozanib can be increased when combined with Chlorphenesin.
Ropeginterferon alfa-2b The risk or severity of neuropsychiatric effects can be increased when Ropeginterferon alfa-2b is combined with Chlorphenesin.
Daridorexant The risk or severity of CNS depression can be increased when Chlorphenesin is combined with Daridorexant.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Chlorphenesin.
Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Chlorphenesin.
Clozapine The serum concentration of Clozapine can be decreased when it is combined with Chlorphenesin.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Chlorphenesin.
Midazolam The risk or severity of sedation and CNS depression can be increased when Midazolam is combined with Chlorphenesin.
Doxorubicin The serum concentration of Doxorubicin can be decreased when it is combined with Chlorphenesin.
Ganaxolone The risk or severity of sedation, somnolence, and CNS depression can be increased when Chlorphenesin is combined with Ganaxolone.
Zuranolone The risk or severity of CNS depression can be increased when Zuranolone is combined with Chlorphenesin.
DaxibotulinumtoxinA Chlorphenesin may increase the neuromuscular blocking activities of DaxibotulinumtoxinA.

Referensi & Sumber

Synthesis reference: Parker, H.E.; U S . Patent 3,214,336; October 26, 1965; assigned to The Upjohn Company. Collins, R.J. and Matthews, R.J.; US. Patent 3,161,567; December 15, 1964; assigned to The Upjohn Company.
Artikel (PubMed)
  • PMID: 4105542
    Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8.
  • PMID: 6503049
    Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13.
  • PMID: 3074423
    Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90.

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Sekuens Gen/Protein (FASTA)

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