Peringatan Keamanan

LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.

Levorphanol

DB00854

small molecule approved

Deskripsi

A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.

Struktur Molekul 2D

Berat 257.3706
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 11-16 hours
Volume Distribusi * 10 to 13 L/kg
Klirens (Clearance) * 0.78 to 1.1 L/kg/hr

Absorpsi

Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.

Metabolisme

Levorphanol is extensively metabolized in the liver and is eliminated as the glucuronide metabolite.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with or without food. Food does not significantly affect absorption.

Interaksi Obat

915 Data
Buprenorphine Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Hydrocodone Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Magnesium sulfate The therapeutic efficacy of Levorphanol can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Levorphanol may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Orphenadrine Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Pramipexole Levorphanol may increase the sedative activities of Pramipexole.
Ropinirole Levorphanol may increase the sedative activities of Ropinirole.
Rotigotine Levorphanol may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Levorphanol.
Sodium oxybate Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Thalidomide Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Alvimopan The risk or severity of adverse effects can be increased when Levorphanol is combined with Alvimopan.
Desmopressin The risk or severity of hyponatremia can be increased when Levorphanol is combined with Desmopressin.
Morphine The risk or severity of adverse effects can be increased when Morphine is combined with Levorphanol.
Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Levorphanol.
Hydromorphone The risk or severity of adverse effects can be increased when Hydromorphone is combined with Levorphanol.
Meperidine The risk or severity of adverse effects can be increased when Meperidine is combined with Levorphanol.
Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Levorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Levorphanol.
Naltrexone The therapeutic efficacy of Levorphanol can be decreased when used in combination with Naltrexone.
Sufentanil The risk or severity of adverse effects can be increased when Sufentanil is combined with Levorphanol.
Alfentanil The risk or severity of adverse effects can be increased when Alfentanil is combined with Levorphanol.
Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Levorphanol is combined with Remifentanil.
Diphenoxylate The risk or severity of adverse effects can be increased when Levorphanol is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Levorphanol is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Levorphanol is combined with Dezocine.
Methadyl acetate The risk or severity of adverse effects can be increased when Levorphanol is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Diamorphine.
Bezitramide The risk or severity of adverse effects can be increased when Levorphanol is combined with Bezitramide.
Ethylmorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Levorphanol is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Levorphanol is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Levorphanol is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Levorphanol is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Dihydromorphine.
Ketobemidone The risk or severity of adverse effects can be increased when Levorphanol is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Levorphanol is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Levorphanol is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Levorphanol is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Levorphanol is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Levorphanol is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Levorphanol is combined with Alphaprodine.
Nicomorphine The risk or severity of adverse effects can be increased when Levorphanol is combined with Nicomorphine.
Meptazinol The therapeutic efficacy of Levorphanol can be decreased when used in combination with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Levorphanol is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Levorphanol is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Levorphanol is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Levorphanol is combined with Carfentanil, C-11.
Naloxegol The risk or severity of adverse effects can be increased when Levorphanol is combined with Naloxegol.
Benzhydrocodone The risk or severity of adverse effects can be increased when Levorphanol is combined with Benzhydrocodone.
Pegvisomant The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Levorphanol.
Succinylcholine The risk or severity of bradycardia can be increased when Succinylcholine is combined with Levorphanol.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Levorphanol.
Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Levorphanol.
Mirtazapine Levorphanol may increase the serotonergic activities of Mirtazapine.
Fluvoxamine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Fluvoxamine.
Citalopram The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Citalopram.
Duloxetine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Duloxetine.
Paroxetine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Paroxetine.
Sertraline The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Sertraline.
Sibutramine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Sibutramine.
Nefazodone The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Nefazodone.
Zimelidine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Zimelidine.
Dapoxetine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Dapoxetine.
Milnacipran The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Milnacipran.
Desvenlafaxine The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Levorphanol.
Seproxetine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Seproxetine.
Levomilnacipran The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Levomilnacipran.
Indalpine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Indalpine.
Ritanserin The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Ritanserin.
Alaproclate The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Alaproclate.
Ethanol Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Levorphanol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
Phentermine Phentermine may increase the analgesic activities of Levorphanol.
Pseudoephedrine Pseudoephedrine may increase the analgesic activities of Levorphanol.
Benzphetamine Benzphetamine may increase the analgesic activities of Levorphanol.
Diethylpropion Diethylpropion may increase the analgesic activities of Levorphanol.
Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Levorphanol is combined with Lisdexamfetamine.
Mephentermine Mephentermine may increase the analgesic activities of Levorphanol.
MMDA MMDA may increase the analgesic activities of Levorphanol.
Midomafetamine Midomafetamine may increase the analgesic activities of Levorphanol.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Levorphanol.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Levorphanol.

Target Protein

Mu-type opioid receptor OPRM1
Delta-type opioid receptor OPRD1
Kappa-type opioid receptor OPRK1

Referensi & Sumber

Synthesis reference: Joseph P. Haar, "Process for the Production of Levorphanol and Related Compounds." U.S. Patent US20080146805, issued June 19, 2008.

Contoh Produk & Brand

Produk: 18 • International brands: 1
Produk
  • Levo-Dromoran
    Injection, solution • 2 mg/1mL • Parenteral • US • Approved
  • Levo-Dromoran
    Injection, solution • 2 mg/1mL • Parenteral • US • Approved
  • Levo-Dromoran
    Tablet • 2 mg/1 • Oral • US • Approved
  • Levorphanol Tartrate
    Tablet • 2 mg/1 • Oral • US • Generic • Approved
  • Levorphanol Tartrate
    Tablet • 2 mg/1 • Oral • US • Approved
  • Levorphanol Tartrate
    Tablet • 2 mg/1 • Oral • US • Generic • Approved
  • Levorphanol Tartrate
    Tablet • 2 mg/1 • Oral • US • Generic • Approved
  • Levorphanol Tartrate
    Tablet • 1 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 18 produk.
International Brands
  • Aromarone

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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