LD50 = 40 mg/kg (Pigs, subcutaneous); LD50 = 180 mg/kg (rat, oral)
Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. A178117 It was manufactured by Janssen and first used in 1969 as an agent to treat worm infestationsA178123 Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer.L6232 Prior to this, levamisole was used as an antirheumatic therapy in the 1970s and 1980s for patients with rheumatoid arthritis.A178123
Because of its immunomodulatory effects, this drug has been studied in the treatment of various immune-mediated diseases, with some studies showing positive results. A178117 This drug has also been used in combination with other drugs for the treatment of various cancers. A178117, A178123
Levamisole was withdrawn from the American market in 2000 due to its ability to cause serious adverse effects, including agranulocytosis. A178123 Interestingly, levamisole has been found as an adulterant in cocaine and can lead to a variety of adverse effects in individuals using this drug.A178120
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ivermectin | The bioavailability of Ivermectin can be increased when combined with Levamisole. |
| Albendazole | The bioavailability of Albendazole can be increased when combined with Levamisole. |