Peringatan Keamanan

Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary- adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients

Flurandrenolide

DB00846

small molecule approved

Deskripsi

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)

Struktur Molekul 2D

Berat 436.5136
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to those of systemically administered corticosteroids

Metabolisme

Primarily hepatic

Rute Eliminasi

Topical corticosteroids can be absorbed from normal intact skin. They are metabolized primarily in the liver and then excreted in the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Interaksi Obat

157 Data
Trastuzumab The risk or severity of neutropenia can be increased when Trastuzumab is combined with Flurandrenolide.
Tacrolimus Tacrolimus may increase the immunosuppressive activities of Flurandrenolide.
Phenylephrine The risk or severity of hypertension can be increased when Flurandrenolide is combined with Phenylephrine.
Aminoglutethimide The therapeutic efficacy of Flurandrenolide can be decreased when used in combination with Aminoglutethimide.
Insulin human The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin human.
Insulin lispro The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin lispro.
Insulin glargine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin glargine.
Insulin pork The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin pork.
Troglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Troglitazone.
Glimepiride The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glimepiride.
Sulfisoxazole The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sulfisoxazole.
Disopyramide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Disopyramide.
Acarbose The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Acarbose.
Metformin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Metformin.
Sulfadiazine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sulfadiazine.
Rosiglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Rosiglitazone.
Acetohexamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Acetohexamide.
Quinine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Quinine.
Miglitol The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Miglitol.
Chlorpropamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Chlorpropamide.
Nateglinide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Nateglinide.
Pentamidine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Pentamidine.
Mifepristone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Mifepristone.
Tolazamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Tolazamide.
Repaglinide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Repaglinide.
Phenformin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Phenformin.
Sulfamethoxazole The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sulfamethoxazole.
Glyburide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glyburide.
Glipizide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glipizide.
Gliclazide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Gliclazide.
Tolbutamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Tolbutamide.
Pioglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Pioglitazone.
Bromocriptine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Bromocriptine.
Gliquidone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Gliquidone.
Mitiglinide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Mitiglinide.
Sitagliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sitagliptin.
Sunitinib The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sunitinib.
Exenatide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Exenatide.
Mecasermin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Mecasermin.
Pramlintide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Pramlintide.
Glisoxepide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glisoxepide.
Insulin aspart The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin aspart.
Insulin detemir The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin detemir.
Insulin glulisine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin glulisine.
Glymidine The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glymidine.
AICA ribonucleotide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with AICA ribonucleotide.
Buformin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Buformin.
Vildagliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Vildagliptin.
Voglibose The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Voglibose.
NN344 The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with NN344.
AMG-222 The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with AMG-222.
Bisegliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Bisegliptin.
Alogliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Alogliptin.
Dapagliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Dapagliflozin.
Saxagliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Saxagliptin.
Liraglutide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Liraglutide.
Gosogliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Gosogliptin.
Linagliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Linagliptin.
Canagliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Canagliflozin.
Glibornuride The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Glibornuride.
Benfluorex The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Benfluorex.
Empagliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Empagliflozin.
Albiglutide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Albiglutide.
Dulaglutide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Dulaglutide.
Lobeglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Lobeglitazone.
Netoglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Netoglitazone.
Rivoglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Rivoglitazone.
Ciglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Ciglitazone.
Lixisenatide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Lixisenatide.
Insulin beef The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin beef.
Insulin degludec The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin degludec.
Insulin peglispro The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin peglispro.
Insulin tregopil The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Insulin tregopil.
Ipragliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Ipragliflozin.
Dutogliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Dutogliptin.
Allicin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Allicin.
Tofogliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Tofogliflozin.
Ertugliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Ertugliflozin.
2,4-thiazolidinedione The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with 2,4-thiazolidinedione.
Teneligliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Teneligliptin.
Omarigliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Omarigliptin.
Carmegliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Carmegliptin.
Gemigliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Gemigliptin.
Anagliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Anagliptin.
Evogliptin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Evogliptin.
Sotagliflozin The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Sotagliflozin.
Balaglitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Balaglitazone.
Remogliflozin etabonate The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Remogliflozin etabonate.
Carbutamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Carbutamide.
Guar gum The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Guar gum.
Metahexamide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Metahexamide.
Semaglutide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Semaglutide.
Taspoglutide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Taspoglutide.
Englitazone The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Englitazone.
Tirzepatide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Tirzepatide.
Gastric inhibitory polypeptide The risk or severity of hyperglycemia can be increased when Flurandrenolide is combined with Gastric inhibitory polypeptide.
Isoniazid The serum concentration of Isoniazid can be decreased when it is combined with Flurandrenolide.
Cyclosporine The risk or severity of adverse effects can be increased when Flurandrenolide is combined with Cyclosporine.
Digoxin The risk or severity of adverse effects can be increased when Flurandrenolide is combined with Digoxin.
Acetyldigitoxin The risk or severity of adverse effects can be increased when Flurandrenolide is combined with Acetyldigitoxin.

Target Protein

Steroid hormone receptor ERR1 ESRRA
Steroid hormone receptor ERR2 ESRRB
Estrogen-related receptor gamma ESRRG
Glucocorticoid receptor NR3C1

Referensi & Sumber

Synthesis reference: Casas-Campillo, C.; U.S. Patent 3,119,748; January 28, 1964; assigned to Syntex Corporation, Panama. Ringold, H.J., Zderic, J.A., Djerassi, C. and Bowers, A.; U.S. Patent 3,126,375; March 24, 1964; assigned to Syntex Corporation, Panama.

Contoh Produk & Brand

Produk: 30 • International brands: 2
Produk
  • Cordran
    Tape • 4 ug/1cm2 • Topical • US • Approved
  • Cordran
    Cream • 0.5 mg/1g • Topical • US • Approved
  • Cordran
    Cream • 0.25 mg/1g • Topical • US • Approved
  • Cordran
    Ointment • 0.5 mg/1g • Topical • US • Approved
  • Cordran
    Ointment • 0.25 mg/1g • Topical • US • Approved
  • Cordran
    Lotion • 0.5 mg/1mL • Topical • US • Approved
  • Cordran
    Lotion • 0.5 mg/1mL • Topical • US • Approved
  • Cordran
    Ointment • 0.25 mg/1g • Topical • US • Approved
Menampilkan 8 dari 30 produk.
International Brands
  • Drenison — Biolab
  • Haelan — Typharm Limited

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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