Peringatan Keamanan

Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.

Brompheniramine

DB00835

small molecule approved

Deskripsi

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Struktur Molekul 2D

Berat 319.239
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Antihistamines are well absorbed from the gastrointestinal tract after oral administration.

Metabolisme

Hepatic (cytochrome P-450 system), some renal.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food.

Interaksi Obat

1291 Data
Buprenorphine Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Magnesium sulfate The therapeutic efficacy of Brompheniramine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Brompheniramine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Mirtazapine Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Orphenadrine Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Pramipexole Brompheniramine may increase the sedative activities of Pramipexole.
Ropinirole Brompheniramine may increase the sedative activities of Ropinirole.
Rotigotine Brompheniramine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Brompheniramine.
Sodium oxybate Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Thalidomide Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Aclidinium The risk or severity of adverse effects can be increased when Brompheniramine is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Brompheniramine.
Mirabegron The risk or severity of urinary retention can be increased when Brompheniramine is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Brompheniramine is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Brompheniramine.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Brompheniramine.
Tiotropium The risk or severity of adverse effects can be increased when Brompheniramine is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Brompheniramine is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Brompheniramine is combined with Umeclidinium.
Benzylpenicilloyl polylysine Brompheniramine may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Brompheniramine.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Brompheniramine.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Brompheniramine.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Brompheniramine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Brompheniramine.
Glycopyrronium The risk or severity of adverse effects can be increased when Brompheniramine is combined with Glycopyrronium.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Brompheniramine is combined with Botulinum toxin type A.
Glucagon Brompheniramine may increase the gastrointestinal motility reducing activities of Glucagon.
Sulpiride Brompheniramine may increase the anticholinergic activities of Sulpiride.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Brompheniramine is combined with Botulinum toxin type B.
Eluxadoline The risk or severity of constipation can be increased when Brompheniramine is combined with Eluxadoline.
Ramosetron The risk or severity of constipation can be increased when Brompheniramine is combined with Ramosetron.
Ethanol Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Brompheniramine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Fluvoxamine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Fluvoxamine.
Duloxetine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Paroxetine.
Sibutramine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Sibutramine.
Zimelidine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Brompheniramine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Seproxetine.
Levomilnacipran The risk or severity of Tachycardia can be increased when Brompheniramine is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Brompheniramine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Brompheniramine is combined with Alaproclate.
Citalopram The risk or severity of QTc prolongation can be increased when Brompheniramine is combined with Citalopram.
Escitalopram The risk or severity of adverse effects can be increased when Brompheniramine is combined with Escitalopram.
Nefazodone The risk or severity of adverse effects can be increased when Brompheniramine is combined with Nefazodone.
Amphetamine Amphetamine may decrease the sedative activities of Brompheniramine.
Phentermine Phentermine may decrease the sedative activities of Brompheniramine.
Benzphetamine Benzphetamine may decrease the sedative activities of Brompheniramine.
Diethylpropion Diethylpropion may decrease the sedative activities of Brompheniramine.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Brompheniramine.
Mephentermine Mephentermine may decrease the sedative activities of Brompheniramine.
MMDA MMDA may decrease the sedative activities of Brompheniramine.
Midomafetamine Midomafetamine may decrease the sedative activities of Brompheniramine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Brompheniramine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Brompheniramine.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Brompheniramine.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Brompheniramine.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Brompheniramine.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Brompheniramine.
Metamfetamine Metamfetamine may decrease the sedative activities of Brompheniramine.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Brompheniramine.
Ritobegron Ritobegron may decrease the sedative activities of Brompheniramine.
Mephedrone Mephedrone may decrease the sedative activities of Brompheniramine.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Brompheniramine.
Gepefrine Gepefrine may decrease the sedative activities of Brompheniramine.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Brompheniramine.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Brompheniramine.
Naltrexone The risk or severity of adverse effects can be increased when Brompheniramine is combined with Naltrexone.
Bezitramide The risk or severity of adverse effects can be increased when Brompheniramine is combined with Bezitramide.
Desomorphine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Desomorphine.
Nicomorphine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Nicomorphine.
Morphine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Morphine.
Hydromorphone The risk or severity of adverse effects can be increased when Brompheniramine is combined with Hydromorphone.
Oxycodone The risk or severity of adverse effects can be increased when Brompheniramine is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Brompheniramine is combined with Butorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Brompheniramine is combined with Dextropropoxyphene.
Pentazocine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Pentazocine.
Sufentanil The risk or severity of adverse effects can be increased when Brompheniramine is combined with Sufentanil.
Nalbuphine The risk or severity of adverse effects can be increased when Brompheniramine is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Brompheniramine is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Brompheniramine is combined with Remifentanil.
Diphenoxylate The risk or severity of adverse effects can be increased when Brompheniramine is combined with Diphenoxylate.

Target Protein

Histamine H1 receptor HRH1
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3
Muscarinic acetylcholine receptor M4 CHRM4
Muscarinic acetylcholine receptor M5 CHRM5

Referensi & Sumber

Synthesis reference: Sperber, N., Papa, D. and Schwenk, E.; US. Patent 2,567,245; September 11, 1951; assigned to Schering Corporation. Sperber, N., Papa, D. and Schwenk, E.; U.S. Patent 2,676,964: April 27,1954; assigned to Schering Corporation.

Contoh Produk & Brand

Produk: 315 • International brands: 5
Produk
  • 7 Select Cold and Allergy Childrens
    Liquid • - • Oral • US • OTC
  • Alahist DM
    Liquid • - • Oral • US • OTC
  • Altidec A
    Liquid • - • Oral • US • OTC
  • Altipres-B
    Liquid • - • Oral • US • OTC
  • AP-Hist DM
    Liquid • - • Oral • US • OTC
  • Assured Childrens Cold and Cough
    Liquid • - • Oral • US • OTC
  • Atuss Da
    Liquid • - • Oral • US • OTC
  • Atuss Da
    Liquid • - • Oral • US • OTC
Menampilkan 8 dari 315 produk.
International Brands
  • Bromfed — Wockhardt USA, LLC
  • Bromfenex — Ethex Corporation
  • Brotane
  • Dimetane — Wyeth
  • Lodrane — ECR Pharmaceuticals

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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