Peringatan Keamanan

Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.

Cefaclor

DB00833

small molecule approved

Deskripsi

Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.

Struktur Molekul 2D

Berat 367.807
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 0.6-0.9 hour
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Well absorbed after oral administration, independent of food intake.

Metabolisme

No appreciable biotransformation in liver (approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours).

Rute Eliminasi

Approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours, the greater portion being excreted within the first 2 hours.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

968 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Troglitazone Troglitazone may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Erythromycin Erythromycin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Reserpine Reserpine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Progesterone Progesterone may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Chlorpromazine Chlorpromazine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cimetidine Cimetidine may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Bosentan Bosentan may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Tamoxifen Tamoxifen may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Tipranavir Tipranavir may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Ethinylestradiol Ethinylestradiol may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Glyburide Glyburide may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Ketoconazole Ketoconazole may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Ursodeoxycholic acid Ursodeoxycholic acid may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cholic Acid Cholic Acid may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Fusidic acid Fusidic acid may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Simeprevir Simeprevir may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Lenvatinib Lenvatinib may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Valinomycin Valinomycin may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Nifedipine Cefaclor may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Olmesartan Olmesartan may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Pralsetinib Pralsetinib may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Probenecid The serum concentration of Cefaclor can be increased when it is combined with Probenecid.
Foscarnet The risk or severity of nephrotoxicity can be increased when Cefaclor is combined with Foscarnet.
Mannitol The risk or severity of nephrotoxicity can be increased when Mannitol is combined with Cefaclor.
Tenofovir disoproxil Cefaclor may increase the nephrotoxic activities of Tenofovir disoproxil.
Tenofovir alafenamide The serum concentration of Tenofovir alafenamide can be increased when it is combined with Cefaclor.
Tenofovir Cefaclor may increase the nephrotoxic activities of Tenofovir.
Aspartame The excretion of Cefaclor can be decreased when combined with Aspartame.
Pravastatin The excretion of Cefaclor can be decreased when combined with Pravastatin.
Aminohippuric acid The excretion of Cefaclor can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Cefaclor can be decreased when combined with Lansoprazole.
Zidovudine The excretion of Cefaclor can be decreased when combined with Zidovudine.
Guanidine The excretion of Cefaclor can be decreased when combined with Guanidine.
Enalapril The excretion of Cefaclor can be decreased when combined with Enalapril.
Oxytetracycline The excretion of Cefaclor can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Cefaclor can be decreased when combined with Leucovorin.
Esomeprazole The excretion of Cefaclor can be decreased when combined with Esomeprazole.
Succinic acid The excretion of Succinic acid can be decreased when combined with Cefaclor.
Citrulline The excretion of Citrulline can be decreased when combined with Cefaclor.
Cefdinir The excretion of Cefdinir can be decreased when combined with Cefaclor.
Fluorescein The excretion of Fluorescein can be decreased when combined with Cefaclor.
Hydrocortisone The excretion of Hydrocortisone can be decreased when combined with Cefaclor.
Quinapril The excretion of Quinapril can be decreased when combined with Cefaclor.
Dinoprostone The excretion of Dinoprostone can be decreased when combined with Cefaclor.
Famotidine The excretion of Famotidine can be decreased when combined with Cefaclor.
Fexofenadine The excretion of Fexofenadine can be decreased when combined with Cefaclor.
Benzylpenicillin The excretion of Benzylpenicillin can be decreased when combined with Cefaclor.
Rosuvastatin The excretion of Rosuvastatin can be decreased when combined with Cefaclor.
Captopril The excretion of Captopril can be decreased when combined with Cefaclor.
Tazobactam The excretion of Tazobactam can be decreased when combined with Cefaclor.
Cyclic adenosine monophosphate The excretion of Cyclic adenosine monophosphate can be decreased when combined with Cefaclor.
Glutaric Acid The excretion of Glutaric Acid can be decreased when combined with Cefaclor.
Oxalic Acid The excretion of Oxalic Acid can be decreased when combined with Cefaclor.
Ellagic acid The excretion of Ellagic acid can be decreased when combined with Cefaclor.
Avibactam The excretion of Avibactam can be decreased when combined with Cefaclor.
Eluxadoline The excretion of Eluxadoline can be decreased when combined with Cefaclor.
Silibinin The excretion of Silibinin can be decreased when combined with Cefaclor.
Relebactam The excretion of Relebactam can be decreased when combined with Cefaclor.
Minocycline The excretion of Cefaclor can be decreased when combined with Minocycline.
Novobiocin The excretion of Cefaclor can be decreased when combined with Novobiocin.
Melatonin The excretion of Cefaclor can be decreased when combined with Melatonin.
Ouabain The excretion of Cefaclor can be decreased when combined with Ouabain.
Liotrix The excretion of Cefaclor can be decreased when combined with Liotrix.
Cilastatin The excretion of Cefaclor can be decreased when combined with Cilastatin.
trans-2-hydroxycinnamic acid The excretion of Cefaclor can be decreased when combined with trans-2-hydroxycinnamic acid.
Benzoic acid The excretion of Cefaclor can be decreased when combined with Benzoic acid.
Caprylic acid The excretion of Cefaclor can be decreased when combined with Caprylic acid.
Ataluren The excretion of Cefaclor can be decreased when combined with Ataluren.
Teriflunomide The excretion of Cefaclor can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Cefaclor can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Cefaclor can be decreased when combined with Dolutegravir.
Cabotegravir The excretion of Cefaclor can be decreased when combined with Cabotegravir.
Pradigastat The excretion of Cefaclor can be decreased when combined with Pradigastat.
Enasidenib The excretion of Cefaclor can be decreased when combined with Enasidenib.
Cefotiam The excretion of Cefaclor can be decreased when combined with Cefotiam.
Indomethacin The excretion of Cefaclor can be decreased when combined with Indomethacin.
Cefalotin The excretion of Cefaclor can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Cefaclor can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Cefaclor can be decreased when combined with Cefotaxime.
Piroxicam The excretion of Cefaclor can be decreased when combined with Piroxicam.
Methotrexate The excretion of Cefaclor can be decreased when combined with Methotrexate.
Cephalexin The excretion of Cefaclor can be decreased when combined with Cephalexin.
Valaciclovir The excretion of Valaciclovir can be decreased when combined with Cefaclor.
Diclofenac The excretion of Cefaclor can be decreased when combined with Diclofenac.
Acyclovir The excretion of Cefaclor can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Cefaclor can be decreased when combined with Phenylbutazone.
Oseltamivir The excretion of Oseltamivir can be decreased when combined with Cefaclor.
Pantoprazole The excretion of Cefaclor can be decreased when combined with Pantoprazole.
Liothyronine The excretion of Cefaclor can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Cefaclor can be decreased when combined with Conjugated estrogens.
Piperacillin The excretion of Piperacillin can be decreased when combined with Cefaclor.
Trifluridine The excretion of Trifluridine can be decreased when combined with Cefaclor.
Allopurinol The excretion of Allopurinol can be decreased when combined with Cefaclor.
Levocarnitine The excretion of Levocarnitine can be decreased when combined with Cefaclor.
Tetracycline The excretion of Cefaclor can be decreased when combined with Tetracycline.
Estradiol The excretion of Estradiol can be decreased when combined with Cefaclor.
Ranitidine The excretion of Ranitidine can be decreased when combined with Cefaclor.
Bumetanide The excretion of Bumetanide can be decreased when combined with Cefaclor.

Target Protein

Penicillin-binding protein 3 pbp3
Penicillin-binding protein 1A pbpA

Referensi & Sumber

Synthesis reference: Bing L. Wong, Yong-Qiang Shen, Yung-Pin Chen, "Enzymatic production of cefaclor from cephalexin." U.S. Patent US5939299, issued November, 1987.
Artikel (PubMed)
  • PMID: 1802903
    Hebert AA, Sigman ES, Levy ML: Serum sickness-like reactions from cefaclor in children. J Am Acad Dermatol. 1991 Nov;25(5 Pt 1):805-8.
  • PMID: 1456417
    Parra FM, Igea JM, Martin JA, Alonso MD, Lezaun A, Sainz T: Serum sickness-like syndrome associated with cefaclor therapy. Allergy. 1992 Aug;47(4 Pt 2):439-40.

Contoh Produk & Brand

Produk: 88 • International brands: 11
Produk
  • Apo-cefaclor
    Capsule • 250 mg • Oral • Canada • Generic • Approved
  • Apo-cefaclor
    Capsule • 500 mg • Oral • Canada • Generic • Approved
  • Apo-cefaclor
    Powder • 125 mg / 5 mL • Oral • Canada • Generic • Approved
  • Apo-cefaclor
    Powder • 250 mg / 5 mL • Oral • Canada • Generic • Approved
  • Apo-cefaclor
    Powder • 375 mg / 5 mL • Oral • Canada • Generic • Approved
  • Ceclor
    Powder, for suspension • 375 mg / 5 mL • Oral • Canada • Approved
  • Ceclor
    Capsule • 250 mg • Oral • Canada • Approved
  • Ceclor
    Capsule • 500 mg • Oral • Canada • Approved
Menampilkan 8 dari 88 produk.
International Brands
  • Alenfral — Choseido Pharmaceutical
  • Alfacet — Galenika
  • Alfatil — Dexo
  • Alfatil LP — Dexo
  • Ceclor CD — Lilly
  • Distaclor — Flynn
  • Keflor — Alphapharm
  • Kefral — Shionogi Seiyaku
  • Panacef — Valeas
  • Panoral — Eberth

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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