Peringatan Keamanan

Adult monkeys have an LD50 of 15 to 20 mg/kg, whereas for young monkeys the LD50 is only 5 mg/kg. Symptoms of overdose include acute central nervous system stimulation, cardiotoxicity causing tachycardia, arrhythmias, hypertension, and cardiovascular collapse. Whilst some patients show signs of toxicity at blood concentrations of 20 µg/L, chronic abusers of amphetamine have been known to have blood concentration of up to 3000 µg/L.

Phenmetrazine

DB00830

small molecule approved illicit

Deskripsi

A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine.

Struktur Molekul 2D

Berat 177.2429
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 16 to 31 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Readily absorbed from the gastro-intestinal tract and buccal mucosa.

Metabolisme

Primarily hepatic (via CYP3A and CYP2D6). Resistant to metabolism by monoamine oxidase. Metabolism involves deamination to para-hydroxyamphetamine and phenylacetone; this latter compound is subsequently oxidize to benzoic acid and excreted as glucuronide or glycine (hippuric acid) conjugate. Smaller amounts of amphetamine are converted to norephedrine by oxidation.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

721 Data
Valsartan Phenmetrazine may decrease the antihypertensive activities of Valsartan.
Ramipril Phenmetrazine may decrease the antihypertensive activities of Ramipril.
Esmolol Phenmetrazine may decrease the antihypertensive activities of Esmolol.
Betaxolol Phenmetrazine may decrease the antihypertensive activities of Betaxolol.
Reserpine Phenmetrazine may decrease the antihypertensive activities of Reserpine.
Remikiren Phenmetrazine may decrease the antihypertensive activities of Remikiren.
Torasemide Phenmetrazine may decrease the antihypertensive activities of Torasemide.
Guanadrel Phenmetrazine may decrease the antihypertensive activities of Guanadrel.
Metoprolol Phenmetrazine may decrease the antihypertensive activities of Metoprolol.
Isradipine Phenmetrazine may decrease the antihypertensive activities of Isradipine.
Olmesartan Phenmetrazine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Phenmetrazine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Phenmetrazine may decrease the antihypertensive activities of Nitroprusside.
Atenolol Phenmetrazine may decrease the antihypertensive activities of Atenolol.
Diltiazem Phenmetrazine may decrease the antihypertensive activities of Diltiazem.
Minoxidil Phenmetrazine may decrease the antihypertensive activities of Minoxidil.
Timolol Phenmetrazine may decrease the antihypertensive activities of Timolol.
Treprostinil Phenmetrazine may decrease the antihypertensive activities of Treprostinil.
Amlodipine Phenmetrazine may decrease the antihypertensive activities of Amlodipine.
Nimodipine Phenmetrazine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Phenmetrazine may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Phenmetrazine may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Phenmetrazine may decrease the antihypertensive activities of Prazosin.
Fosinopril Phenmetrazine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Phenmetrazine may decrease the antihypertensive activities of Trandolapril.
Metolazone Phenmetrazine may decrease the antihypertensive activities of Metolazone.
Lercanidipine Phenmetrazine may decrease the antihypertensive activities of Lercanidipine.
Benazepril Phenmetrazine may decrease the antihypertensive activities of Benazepril.
Bosentan Phenmetrazine may decrease the antihypertensive activities of Bosentan.
Propranolol Phenmetrazine may decrease the antihypertensive activities of Propranolol.
Enalapril Phenmetrazine may decrease the antihypertensive activities of Enalapril.
Doxazosin Phenmetrazine may decrease the antihypertensive activities of Doxazosin.
Cyclothiazide Phenmetrazine may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Phenmetrazine may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Phenmetrazine may decrease the antihypertensive activities of Candoxatril.
Nicardipine Phenmetrazine may decrease the antihypertensive activities of Nicardipine.
Mecamylamine Phenmetrazine may decrease the antihypertensive activities of Mecamylamine.
Losartan Phenmetrazine may decrease the antihypertensive activities of Losartan.
Moexipril Phenmetrazine may decrease the antihypertensive activities of Moexipril.
Eplerenone Phenmetrazine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Phenmetrazine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Phenmetrazine may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Phenmetrazine may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Phenmetrazine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Phenmetrazine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Phenmetrazine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Phenmetrazine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Phenmetrazine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Phenmetrazine may decrease the antihypertensive activities of Indapamide.
Tadalafil Phenmetrazine may decrease the antihypertensive activities of Tadalafil.
Alprenolol Phenmetrazine may decrease the antihypertensive activities of Alprenolol.
Eprosartan Phenmetrazine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Phenmetrazine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Phenmetrazine may decrease the antihypertensive activities of Quinapril.
Pindolol Phenmetrazine may decrease the antihypertensive activities of Pindolol.
Telmisartan Phenmetrazine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Phenmetrazine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Phenmetrazine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Phenmetrazine may decrease the antihypertensive activities of Trichlormethiazide.
Felodipine Phenmetrazine may decrease the antihypertensive activities of Felodipine.
Irbesartan Phenmetrazine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Phenmetrazine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Phenmetrazine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Phenmetrazine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Phenmetrazine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Phenmetrazine may decrease the antihypertensive activities of Diazoxide.
Carvedilol Phenmetrazine may decrease the antihypertensive activities of Carvedilol.
Bretylium Phenmetrazine may decrease the antihypertensive activities of Bretylium.
Terazosin Phenmetrazine may decrease the antihypertensive activities of Terazosin.
Guanethidine Phenmetrazine may decrease the antihypertensive activities of Guanethidine.
Captopril Phenmetrazine may decrease the antihypertensive activities of Captopril.
Nadolol Phenmetrazine may decrease the antihypertensive activities of Nadolol.
Epoprostenol Phenmetrazine may decrease the antihypertensive activities of Epoprostenol.
Bepridil Phenmetrazine may decrease the antihypertensive activities of Bepridil.
Hydralazine Phenmetrazine may decrease the antihypertensive activities of Hydralazine.
Bevantolol Phenmetrazine may decrease the antihypertensive activities of Bevantolol.
Practolol Phenmetrazine may decrease the antihypertensive activities of Practolol.
Polythiazide Phenmetrazine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Phenmetrazine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Phenmetrazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Phenmetrazine may decrease the antihypertensive activities of Spirapril.
Penbutolol Phenmetrazine may decrease the antihypertensive activities of Penbutolol.
Mibefradil Phenmetrazine may decrease the antihypertensive activities of Mibefradil.
Oxprenolol Phenmetrazine may decrease the antihypertensive activities of Oxprenolol.
Dexpropranolol Phenmetrazine may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Phenmetrazine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Phenmetrazine may decrease the antihypertensive activities of Debrisoquine.
Nebivolol Phenmetrazine may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Phenmetrazine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Phenmetrazine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Phenmetrazine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Phenmetrazine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Phenmetrazine may decrease the antihypertensive activities of Pinacidil.
Bupranolol Phenmetrazine may decrease the antihypertensive activities of Bupranolol.
Temocapril Phenmetrazine may decrease the antihypertensive activities of Temocapril.
Riociguat Phenmetrazine may decrease the antihypertensive activities of Riociguat.
Macitentan Phenmetrazine may decrease the antihypertensive activities of Macitentan.
Indenolol Phenmetrazine may decrease the antihypertensive activities of Indenolol.
Hexamethonium Phenmetrazine may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Phenmetrazine may decrease the antihypertensive activities of Aliskiren.

Target Protein

Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent dopamine transporter SLC6A3

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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