Peringatan Keamanan

Acute toxicology studies have found that oral fosfomycin doses 50-125 times the human therapeutic dose were well-tolerated in rats and mice, resulted in minor and transient watery stools in rabbits, and caused diarrhea with anorexia in dogs 2-3 days after single-dose administration.L31818

In humans, symptoms of overdose have included impaired hearing, vestibular loss, general decline in taste perception, and metallic taste. In the event of overdose, the patient should be managed with symptomatic and supportive measures.L31818

Fosfomycin

DB00828

small molecule approved

Deskripsi

Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by Streptomyces fradiae.A229338,A230348 It may also be produced synthetically and is commercially available as the disodium salt for intravenous administration and as the calcium or trometamol salt for oral administration.A230348 In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.A230348

Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated urinary tract infections (UTIs) in females.A230378 Despite being FDA approved only for urinary tract infections, fosfomycin actually has a broad spectrum of activity and is active against both gram-positive and gram-negative bacteria.A230348 As such there is great interest in exploring the usefulness of fosfomycin for indications beyond the treatment of UTIs.A230353,A230358

Struktur Molekul 2D

Berat 138.059
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean elimination half-life of fosfomycin is 5.7 (?2.8) hours.[L31818]
Volume Distribusi In healthy subjects, the volume of distribution (Vd) of fosfomycin is approximately 0.3 L/Kg.[A229343] Due to changes in the vascular endothelium, the Vd can be up to 50% higher in critically ill patients.[A229343]
Klirens (Clearance) In one study, the reported CL/F of fosfomycin in healthy volunteers was 17 ? 4.7 L/hour.[A230443]

Absorpsi

Fosfomycin is a low molecular weight and hydrophilic drug. When administered orally, fosfomycin is rapidly absorbed in the small intestine and distributed widely to the tissues.A229338,A229343,A229348,L31818 The oral bioavailability ranges from 34-58%.A229338 Co-administration of fosfomycin with food decreases gastrointestinal absorption to approximately 30%.A229338 The reported AUC = 145-228 mg x h/L, while the reported Cmax = 26.1 (?9.1) mcg/mL.A229338,L31818

Metabolisme

Fosfomycin is not metabolized and is predominantly excreted unchanged in the urine.A229343,A229348

Rute Eliminasi

Fosfomycin is excreted almost entirely by the kidneys.A229343 Factors including administration with food, impaired renal function, and older age may reduce the rate of fosfomycin elimination.A229338

Interaksi Makanan

1 Data
  • 1. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

776 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Fosfomycin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Fosfomycin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Fosfomycin.
Cyclosporine Cyclosporine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Meloxicam The risk or severity of methemoglobinemia can be increased when Fosfomycin is combined with Meloxicam.
Carprofen Carprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.

Target Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA

Referensi & Sumber

Synthesis reference: Graziano Castaldi, Claudio Giordano, "Process for the preparation of intermediates for the synthesis of fosfomycin." U.S. Patent US4937367, issued March, 1972.
Artikel (PubMed)
  • PMID: 26960938
    Falagas ME, Vouloumanou EK, Samonis G, Vardakas KZ: Fosfomycin. Clin Microbiol Rev. 2016 Apr;29(2):321-47. doi: 10.1128/CMR.00068-15.
  • PMID: 31131588
    Rodriguez-Gascon A, Canut-Blasco A: Deciphering pharmacokinetics and pharmacodynamics of fosfomycin. Rev Esp Quimioter. 2019 May;32 Suppl 1:19-24.
  • PMID: 21914036
    Raz R: Fosfomycin: an old--new antibiotic. Clin Microbiol Infect. 2012 Jan;18(1):4-7. doi: 10.1111/j.1469-0691.2011.03636.x. Epub 2011 Sep 13.
  • PMID: 15771570
    Segal AW: How neutrophils kill microbes. Annu Rev Immunol. 2005;23:197-223. doi: 10.1146/annurev.immunol.23.021704.115653.
  • PMID: 31131587
    Diez-Aguilar M, Canton R: New microbiological aspects of fosfomycin. Rev Esp Quimioter. 2019 May;32 Suppl 1:8-18.
  • PMID: 18444827
    Falagas ME, Giannopoulou KP, Kokolakis GN, Rafailidis PI: Fosfomycin: use beyond urinary tract and gastrointestinal infections. Clin Infect Dis. 2008 Apr 1;46(7):1069-77. doi: 10.1086/527442.
  • PMID: 31131589
    Veganzones J, Montero A, Maseda E: New evidence on the use of fosfomycin for bacteremia and infectious endocarditis. Rev Esp Quimioter. 2019 May;32 Suppl 1:25-29.
  • PMID: 30765904
    Gardiner BJ, Stewardson AJ, Abbott IJ, Peleg AY: Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems. Aust Prescr. 2019 Feb;42(1):14-19. doi: 10.18773/austprescr.2019.002. Epub 2019 Feb 1.
Menampilkan 8 dari 9 artikel.

Contoh Produk & Brand

Produk: 15 • International brands: 1
Produk
  • Fosfomycin Powder for Oral Solution
    Powder, for solution • 3 g / sachet • Oral • Canada • Approved
  • Fosfomycin Tromethamine
    Powder • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Powder • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Granule, for solution • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Powder • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Granule, for solution • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Granule, for solution • 3 g/1 • Oral • US • Generic • Approved
  • Fosfomycin Tromethamine
    Granule, for solution • 3 g/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 15 produk.
International Brands
  • Veramina — Roux-Ocefa

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul