Natamycin

DB00826

small molecule approved

Deskripsi

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. PubChem

Struktur Molekul 2D

Berat 665.733
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

37 Data
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Natamycin.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Natamycin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Quinisocaine.
Cisatracurium Natamycin may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Natamycin is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Natamycin.

Target Protein

Ergosterol

Referensi & Sumber

Synthesis reference: Michael A. Eisenschink, Phillip T. Olson, "Fermentation process for producing natamycin." U.S. Patent US5231014, issued July, 1982.

Contoh Produk & Brand

Produk: 3 • International brands: 14
Produk
  • Natacyn
    Suspension / drops • 50 mg/1mL • Ophthalmic • US • Approved
  • Natacyn
    Suspension / drops • 50 mg/1mL • Ophthalmic • US • Approved
  • Natacyn
    Suspension / drops • 50 mg/1mL • Ophthalmic • US • Approved
International Brands
  • Delvocid
  • Fukricin — Sanbe
  • InfectoMyk — Infectopharm
  • N-Mycin — Aristopharma
  • Natadrops — Cipla
  • Natamet — Sun
  • Natamycyna — Unia
  • Natezhen — Alcon
  • Natoph — Ibn Sina
  • Natoptic — FDC

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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