Peringatan Keamanan

LD50=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension.

Disulfiram

DB00822

small molecule approved

Deskripsi

A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.

Struktur Molekul 2D

Berat 296.539
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose).

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol. Avoid alcohol for up to 14 days after discontinuation.
  • 2. Take with or without food. The absorption is unaffected by food.

Interaksi Obat

871 Data
Troglitazone Troglitazone may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Erythromycin The serum concentration of Disulfiram can be increased when it is combined with Erythromycin.
Reserpine Reserpine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Progesterone Progesterone may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Chlorpromazine Chlorpromazine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cimetidine Cimetidine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Bosentan Bosentan may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Ethinylestradiol Ethinylestradiol may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Glyburide Glyburide may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Ursodeoxycholic acid Ursodeoxycholic acid may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Cholic Acid Cholic Acid may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Fusidic acid Fusidic acid may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Simeprevir Simeprevir may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Lenvatinib Lenvatinib may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Letermovir The metabolism of Disulfiram can be decreased when combined with Letermovir.
Valinomycin Valinomycin may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Olmesartan Olmesartan may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Pralsetinib Pralsetinib may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Quinidine Quinidine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Disulfiram.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Disulfiram.
Caffeine The serum concentration of Caffeine can be increased when it is combined with Disulfiram.
Theophylline The serum concentration of Theophylline can be increased when it is combined with Disulfiram.
Dyphylline The serum concentration of Dyphylline can be increased when it is combined with Disulfiram.
Pentoxifylline The serum concentration of Pentoxifylline can be increased when it is combined with Disulfiram.
Mercaptopurine The serum concentration of Mercaptopurine can be increased when it is combined with Disulfiram.
Aminophylline The serum concentration of Aminophylline can be increased when it is combined with Disulfiram.
Oxtriphylline The serum concentration of Oxtriphylline can be increased when it is combined with Disulfiram.
Theobromine The serum concentration of Theobromine can be increased when it is combined with Disulfiram.
Fenethylline The serum concentration of Fenethylline can be increased when it is combined with Disulfiram.
8-azaguanine The serum concentration of 8-azaguanine can be increased when it is combined with Disulfiram.
7,9-Dimethylguanine The serum concentration of 7,9-Dimethylguanine can be increased when it is combined with Disulfiram.
Xanthine The serum concentration of Xanthine can be increased when it is combined with Disulfiram.
7-Deazaguanine The serum concentration of 7-Deazaguanine can be increased when it is combined with Disulfiram.
Guanine The serum concentration of Guanine can be increased when it is combined with Disulfiram.
9-Methylguanine The serum concentration of 9-Methylguanine can be increased when it is combined with Disulfiram.
Peldesine The serum concentration of Peldesine can be increased when it is combined with Disulfiram.
Hypoxanthine The serum concentration of Hypoxanthine can be increased when it is combined with Disulfiram.
9-Deazaguanine The serum concentration of 9-Deazaguanine can be increased when it is combined with Disulfiram.
Propentofylline The serum concentration of Propentofylline can be increased when it is combined with Disulfiram.
Valomaciclovir The serum concentration of Valomaciclovir can be increased when it is combined with Disulfiram.
3-isobutyl-1-methyl-7H-xanthine The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Disulfiram.
Uric acid The serum concentration of Uric acid can be increased when it is combined with Disulfiram.
Doxofylline The serum concentration of Doxofylline can be increased when it is combined with Disulfiram.
6-O-benzylguanine The serum concentration of 6-O-benzylguanine can be increased when it is combined with Disulfiram.
Lisofylline The serum concentration of Lisofylline can be increased when it is combined with Disulfiram.
Lobucavir The serum concentration of Lobucavir can be increased when it is combined with Disulfiram.
Cafedrine The serum concentration of Cafedrine can be increased when it is combined with Disulfiram.
Theodrenaline The serum concentration of Theodrenaline can be increased when it is combined with Disulfiram.
Bamifylline The serum concentration of Bamifylline can be increased when it is combined with Disulfiram.
Proxyphylline The serum concentration of Proxyphylline can be increased when it is combined with Disulfiram.
Acefylline The serum concentration of Acefylline can be increased when it is combined with Disulfiram.
Etamiphylline The serum concentration of Etamiphylline can be increased when it is combined with Disulfiram.
Pentifylline The serum concentration of Pentifylline can be increased when it is combined with Disulfiram.
Bufylline The serum concentration of Bufylline can be increased when it is combined with Disulfiram.
Bromotheophylline The serum concentration of Bromotheophylline can be increased when it is combined with Disulfiram.
Furafylline The serum concentration of Furafylline can be increased when it is combined with Disulfiram.
8-chlorotheophylline The serum concentration of 8-chlorotheophylline can be increased when it is combined with Disulfiram.
PCS-499 The serum concentration of PCS-499 can be increased when it is combined with Disulfiram.
Ritonavir The risk or severity of adverse effects can be increased when Ritonavir is combined with Disulfiram.
Dicoumarol Disulfiram may increase the anticoagulant activities of Dicoumarol.
Phenindione Disulfiram may increase the anticoagulant activities of Phenindione.
Warfarin Disulfiram may increase the anticoagulant activities of Warfarin.
Phenprocoumon Disulfiram may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Disulfiram may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Disulfiram may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Disulfiram may increase the anticoagulant activities of Coumarin.
(R)-warfarin Disulfiram may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Disulfiram may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Disulfiram may increase the anticoagulant activities of Fluindione.
Clorindione Disulfiram may increase the anticoagulant activities of Clorindione.
Diphenadione Disulfiram may increase the anticoagulant activities of Diphenadione.
Tioclomarol Disulfiram may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Disulfiram may increase the anticoagulant activities of (S)-Warfarin.
Atazanavir The therapeutic efficacy of Disulfiram can be decreased when used in combination with Atazanavir.
Carbocisteine The risk or severity of adverse effects can be increased when Disulfiram is combined with Carbocisteine.
Isoniazid The risk or severity of adverse effects can be increased when Disulfiram is combined with Isoniazid.
Paraldehyde The serum concentration of Paraldehyde can be increased when it is combined with Disulfiram.
Sertraline The risk or severity of adverse effects can be increased when Disulfiram is combined with Sertraline.
Tinidazole The risk or severity of adverse effects can be increased when Tinidazole is combined with Disulfiram.
Tipranavir The risk or severity of adverse effects can be increased when Disulfiram is combined with Tipranavir.
Ethanol The risk or severity of adverse effects can be increased when Disulfiram is combined with Ethanol.
Metronidazole The risk or severity of psychotic reaction can be increased when Disulfiram is combined with Metronidazole.
Leuprolide The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Leuprolide.
Goserelin The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Goserelin.
Azithromycin The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Azithromycin.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Moxifloxacin.
Ranolazine Ranolazine may decrease the excretion rate of Disulfiram which could result in a higher serum level.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Sulfisoxazole.
Methadone The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Methadone.
Diltiazem The metabolism of Disulfiram can be decreased when combined with Diltiazem.
Clozapine The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Clozapine.
Sulpiride The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Sulpiride.
Nimodipine The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Nimodipine.
Promazine The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Promazine.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Prochlorperazine.
Droperidol The risk or severity of QTc prolongation can be increased when Disulfiram is combined with Droperidol.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Disulfiram.
Ciprofloxacin The metabolism of Disulfiram can be decreased when combined with Ciprofloxacin.

Target Protein

Dopamine beta-hydroxylase DBH
Aldehyde dehydrogenase family 3 member A2 ALDH3A2
Aldehyde dehydrogenase, mitochondrial ALDH2

Referensi & Sumber

Synthesis reference: Adams, H.S. and Meuser, L.; US.Patent 1,782,111; November 18,1930; assigned to The Naugatuck Chemical Company. Bailey, G.C.; U.S.Patent 1,796,977; March 17,1931; assigned to The Roessler & Hasslacher Chemical Company.
Artikel (PubMed)
  • PMID: 9624499
    Nash T, Rice WG: Efficacies of zinc-finger-active drugs against Giardia lamblia. Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92.
  • PMID: 10052908
    Bouma MJ, Snowdon D, Fairlamb AH, Ackers JP: Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20.
  • PMID: 19720750
    Gaval-Cruz M, Weinshenker D: mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv. 2009 Aug;9(4):175-87. doi: 10.1124/mi.9.4.6.

Contoh Produk & Brand

Produk: 27 • International brands: 7
Produk
  • Antabuse
    Tablet • 250 mg/1 • Oral • US • Generic • Approved
  • Antabuse
    Tablet • 250 mg/1 • Oral • US • Generic • Approved
  • Antabuse
    Tablet • 500 mg/1 • Oral • US • Generic • Approved
  • Antabuse Tab 0.25gm
    Tablet • 250 mg / tab • Oral • Canada • Approved
  • Antabuse Tab 250mg
    Tablet • 250 mg / tab • Oral • Canada • Approved
  • Antabuse Tab 500mg
    Tablet • 500 mg / tab • Oral • Canada • Approved
  • Disulfiram
    Tablet • 250 mg/1 • Oral • US • Generic • Approved
  • Disulfiram
    Tablet • 500 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 27 produk.
International Brands
  • Antabus — Actavis
  • Antaethyl — Sanofi
  • Antalcol — Sintofarm
  • Anticol — Polfa Warszawa
  • Antietanol — Sanofi
  • Chronol — Charoon Bhesaj
  • Esperal — Sanofi

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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