Peringatan Keamanan

Symptoms of NSAID overdose include dizziness and nystagmus. Oral LD50 in mouse and rat is 282 mg/kg and 149 mg/kg, respectively.

Carprofen

DB00821

small molecule approved vet_approved withdrawn

Deskripsi

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. It is no longer marketed for human usage, after being withdrawn on commercial grounds.

Struktur Molekul 2D

Berat 273.714
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximately 8 hours (range 4.5–9.8 hours) in dogs.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1428 Data
Amlodipine Carprofen may decrease the antihypertensive activities of Amlodipine.
Porfimer sodium Carprofen may increase the photosensitizing activities of Porfimer sodium.
Verteporfin Carprofen may increase the photosensitizing activities of Verteporfin.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Carprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Carprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Carprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Carprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Carprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Carprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Carprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Carprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Carprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Carprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Carprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Carprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Carprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Carprofen.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Carprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Carprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Carprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Carprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Carprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Carprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Carprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Carprofen.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Carprofen.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Carprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Carprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Carprofen.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Carprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Carprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Carprofen.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Carprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Carprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Carprofen.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Carprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Carprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Carprofen.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Carprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Carprofen is combined with Phenmetrazine.
Trifluoperazine The risk or severity of hypertension can be increased when Carprofen is combined with Trifluoperazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Carprofen is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Carprofen is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Carprofen is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Carprofen is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Carprofen is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Carprofen is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Carprofen is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Carprofen is combined with Diethylpropion.
Salmeterol The risk or severity of hypertension can be increased when Carprofen is combined with Salmeterol.
Naratriptan The risk or severity of hypertension can be increased when Carprofen is combined with Naratriptan.
Formoterol The risk or severity of hypertension can be increased when Carprofen is combined with Formoterol.
Frovatriptan The risk or severity of hypertension can be increased when Carprofen is combined with Frovatriptan.
Methoxyflurane The risk or severity of hypertension can be increased when Carprofen is combined with Methoxyflurane.
Selegiline The risk or severity of hypertension can be increased when Carprofen is combined with Selegiline.
Ergoloid mesylate The risk or severity of hypertension can be increased when Carprofen is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Carprofen is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Carprofen is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Carprofen is combined with Dutasteride.
Halothane The risk or severity of hypertension can be increased when Carprofen is combined with Halothane.
Moclobemide The risk or severity of hypertension can be increased when Carprofen is combined with Moclobemide.
Pergolide The risk or severity of hypertension can be increased when Carprofen is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Carprofen is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Carprofen is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Carprofen is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Carprofen is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Carprofen is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Carprofen is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Carprofen is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Carprofen is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Carprofen is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Carprofen is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Carprofen is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Carprofen is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Carprofen is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Carprofen is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Carprofen is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Carprofen is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Carprofen is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Carprofen is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Carprofen is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Carprofen is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Carprofen is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Carprofen is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Carprofen is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Carprofen is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Carprofen is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Carprofen is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Carprofen is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Carprofen is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Carprofen is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Carprofen is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Carprofen is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Carprofen is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Carprofen is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Carprofen is combined with 1-benzylimidazole.
Iproniazid The risk or severity of hypertension can be increased when Carprofen is combined with Iproniazid.
Nialamide The risk or severity of hypertension can be increased when Carprofen is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Carprofen is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Carprofen is combined with Dronedarone.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Synthesis reference: Berger, L. and Corraz, A.J.; US. Patent 3,896,145; July 22,1975; assigned to Hoffmann- LaRoche, Inc.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • lmadyl — Roche
  • lmafen — Roche
  • Rimadyt — Roche

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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