One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cyclosporine | The serum concentration of Cyclosporine can be increased when it is combined with Acetazolamide. |
| Buprenorphine | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Acetazolamide. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Hydrocodone | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Magnesium sulfate | The therapeutic efficacy of Acetazolamide can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Acetazolamide may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Mirtazapine | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Orphenadrine | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Pramipexole | Acetazolamide may increase the sedative activities of Pramipexole. |
| Ropinirole | Acetazolamide may increase the sedative activities of Ropinirole. |
| Rotigotine | Acetazolamide may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Acetazolamide. |
| Sodium oxybate | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Thalidomide | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Acetazolamide. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Acetazolamide. |
| Nicotine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Nicotine. |
| Mecamylamine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Mecamylamine. |
| Pentolinium | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Pentolinium. |
| Trimethaphan | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Trimethaphan. |
| Hexamethonium | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Hexamethonium. |
| Cyclopentamine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Cyclopentamine. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with Acetazolamide. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Acetazolamide. |
| Fentanyl | The risk or severity of CNS depression can be increased when Fentanyl is combined with Acetazolamide. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Acetazolamide. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Acetazolamide. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Acetazolamide. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Acetazolamide. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Acetazolamide. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Acetazolamide. |
| Mefloquine | The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Mefloquine. |
| Mianserin | The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Mianserin. |
| Orlistat | Orlistat can cause a decrease in the absorption of Acetazolamide resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Topotecan | Acetazolamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
| Flecainide | The excretion of Flecainide can be decreased when combined with Acetazolamide. |
| Memantine | The excretion of Memantine can be decreased when combined with Acetazolamide. |
| Methylphenobarbital | The serum concentration of Methylphenobarbital can be decreased when it is combined with Acetazolamide. |
| Phenobarbital | The serum concentration of Phenobarbital can be decreased when it is combined with Acetazolamide. |
| Quinine | The excretion of Quinine can be decreased when combined with Acetazolamide. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Acetazolamide. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Acetazolamide. |
| Methotrexate | The therapeutic efficacy of Methotrexate can be increased when used in combination with Acetazolamide. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Acetazolamide. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Acetazolamide. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Acetazolamide. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Acetazolamide. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Acetazolamide. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Acetazolamide. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Acetazolamide. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Acetazolamide. |
| Carbamazepine | The serum concentration of Carbamazepine can be increased when it is combined with Acetazolamide. |
| Metformin | The risk or severity of lactic acidosis can be increased when Acetazolamide is combined with Metformin. |
| Tetracosactide | The risk or severity of liver damage can be increased when Tetracosactide is combined with Acetazolamide. |
| Sodium bicarbonate | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium bicarbonate. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Acetazolamide. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Acetazolamide. |
| Ethanol | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Seproxetine. |
| Levomilnacipran | Acetazolamide may increase the excretion rate of Levomilnacipran which could result in a lower serum level and potentially a reduction in efficacy. |
| Indalpine | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Acetazolamide is combined with Alaproclate. |
| Dexketoprofen | The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Acetazolamide. |
| Ketoprofen | The risk or severity of adverse effects can be increased when Ketoprofen is combined with Acetazolamide. |
| Triethylenetetramine | The excretion of Triethylenetetramine can be increased when combined with Acetazolamide. |
| Benzatropine | Acetazolamide may increase the excretion rate of Benzatropine which could result in a lower serum level and potentially a reduction in efficacy. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Acetazolamide. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Acetazolamide. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Acetazolamide. |
| Propantheline | Acetazolamide may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy. |
| Dicyclomine | Acetazolamide may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy. |
| Maprotiline | The risk or severity of CNS depression can be increased when Acetazolamide is combined with Maprotiline. |
| Flavoxate | Acetazolamide may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy. |