Peringatan Keamanan

Oral (LD50): Acute: 1288 mg/kg Rat

Sodium lauryl sulfate

DB00815

small molecule experimental

Deskripsi

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.

Struktur Molekul 2D

Berat 288.379

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data

1. Take after a meal. When Sodium lauryl sulfate is formulated in paste form for oral health, it should be used after meals.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Albumin ALB

Referensi & Sumber

Synthesis reference: Willi Breitzke, Hermann Hensen, "Aqueous preparations of sodium lauryl sulfate and myristyl sulfate having a low cloud point useful in making toothpastes." U.S. Patent US4876035, issued June, 1960.

Artikel (PubMed)

PMID: 1681644
Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300.
PMID: 16679819
Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4.
PMID: 10344477
Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42.
PMID: 9656847
Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40.
PMID: 8811135
Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3.
PMID: 11899262
Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30.

Contoh Produk & Brand

Produk: 11 • International brands: 5

Produk

Bamboo Salt

Paste, dentifrice • 0.7675 g/100g • Oral • US • OTC
Bamboo Salt 160g

Paste, dentifrice • 1.21 g/160g • Oral • US • OTC
Dr.G Hydra Intensive Moist Cleansing gel

Liquid • 25 g/100mL • Topical • US • OTC
For Sope

Liquid • - • Topical • Canada • OTC • Approved
Liquid

Liquid • - • Cutaneous • US • OTC
Liquid

Lotion • - • Cutaneous • US • OTC
Medi Hydro DP Cleanser

Cream • - • Topical • US • OTC
Plax Anti-plaque Dental Rinse

Liquid • - • Dental • Canada • OTC • Approved

Menampilkan 8 dari 11 produk.

International Brands

Anticerumen
Emal 10
Empicol
Genapol LSS
Irium

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.