Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Phenylbutazone. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Phenylbutazone. |
| Midodrine | The risk or severity of hypertension can be increased when Midodrine is combined with Phenylbutazone. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Phenylbutazone. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Phenylbutazone. |
| Norepinephrine | The risk or severity of hypertension can be increased when Norepinephrine is combined with Phenylbutazone. |
| Phenylephrine | The risk or severity of hypertension can be increased when Phenylephrine is combined with Phenylbutazone. |
| Phenylpropanolamine | The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Phenylbutazone. |
| Droperidol | The risk or severity of hypertension can be increased when Droperidol is combined with Phenylbutazone. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Phenylbutazone. |
| Atropine | The risk or severity of hypertension can be increased when Atropine is combined with Phenylbutazone. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Phenylbutazone. |
| Metaraminol | The risk or severity of hypertension can be increased when Metaraminol is combined with Phenylbutazone. |
| Furazolidone | The risk or severity of hypertension can be increased when Furazolidone is combined with Phenylbutazone. |
| Thioridazine | The risk or severity of hypertension can be increased when Thioridazine is combined with Phenylbutazone. |
| Nicergoline | The risk or severity of hypertension can be increased when Nicergoline is combined with Phenylbutazone. |
| Methoxamine | The risk or severity of hypertension can be increased when Methoxamine is combined with Phenylbutazone. |
| Isoflurane | The risk or severity of hypertension can be increased when Isoflurane is combined with Phenylbutazone. |
| Propiomazine | The risk or severity of hypertension can be increased when Propiomazine is combined with Phenylbutazone. |
| Minaprine | The risk or severity of hypertension can be increased when Minaprine is combined with Phenylbutazone. |
| Orciprenaline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Orciprenaline. |
| Phenmetrazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Phenmetrazine. |
| Trifluoperazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Trifluoperazine. |
| Pseudoephedrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pseudoephedrine. |
| Ritodrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Ritodrine. |
| Flupentixol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Flupentixol. |
| Remifentanil | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Remifentanil. |
| Bitolterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Bitolterol. |
| Oxymetazoline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Oxymetazoline. |
| Diethylpropion | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Diethylpropion. |
| Naratriptan | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Naratriptan. |
| Frovatriptan | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Frovatriptan. |
| Isoprenaline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Isoprenaline. |
| Arbutamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Arbutamine. |
| Desflurane | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Desflurane. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Isocarboxazid. |
| Lisdexamfetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Lisdexamfetamine. |
| Fenoterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Fenoterol. |
| Pirbuterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pirbuterol. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Ephedra sinica root. |
| Ephedrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Ephedrine. |
| Mephentermine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Mephentermine. |
| Procaterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Procaterol. |
| Methotrimeprazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Methotrimeprazine. |
| Clenbuterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Clenbuterol. |
| Bambuterol | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Bambuterol. |
| MMDA | The risk or severity of hypertension can be increased when Phenylbutazone is combined with MMDA. |
| Midomafetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Midomafetamine. |
| 2,5-Dimethoxy-4-ethylamphetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with 2,5-Dimethoxy-4-ethylamphetamine. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with 4-Methoxyamphetamine. |
| 4-Bromo-2,5-dimethoxyamphetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with 4-Bromo-2,5-dimethoxyamphetamine. |
| Tenamfetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Tenamfetamine. |
| Chlorphentermine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Chlorphentermine. |
| Dextroamphetamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Dextroamphetamine. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Phendimetrazine. |
| Periciazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Periciazine. |
| Acepromazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Acepromazine. |
| Thioproperazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Thioproperazine. |
| Epicaptopril | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Epicaptopril. |
| Clorgiline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Clorgiline. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when Phenylbutazone is combined with 1-benzylimidazole. |
| Nialamide | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Nialamide. |
| Amibegron | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Amibegron. |
| Naluzotan | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Naluzotan. |
| Pizotifen | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pizotifen. |
| Solabegron | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Solabegron. |
| Esmirtazapine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Esmirtazapine. |
| Nitrous oxide | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Nitrous oxide. |
| Xylometazoline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Xylometazoline. |
| Dexmethylphenidate | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Dexmethylphenidate. |
| Isometheptene | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Isometheptene. |
| Levonordefrin | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Levonordefrin. |
| Naphazoline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Naphazoline. |
| Tetryzoline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Tetryzoline. |
| Cinitapride | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Cinitapride. |
| Tyramine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Tyramine. |
| Adrafinil | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Adrafinil. |
| Isoxsuprine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Isoxsuprine. |
| Ifenprodil | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Ifenprodil. |
| Hexoprenaline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Hexoprenaline. |
| Etilefrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Etilefrine. |
| Cirazoline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Cirazoline. |
| Synephrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Synephrine. |
| Hydracarbazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Hydracarbazine. |
| Benmoxin | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Benmoxin. |
| Mebanazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Mebanazine. |
| Octamoxin | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Octamoxin. |
| Pheniprazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pheniprazine. |
| Phenoxypropazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Phenoxypropazine. |
| Pivhydrazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Pivhydrazine. |
| Safrazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Safrazine. |
| Caroxazone | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Caroxazone. |
| Doxofylline | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Doxofylline. |
| Iofetamine I-123 | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Iofetamine I-123. |
| Racepinephrine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Racepinephrine. |
| Amitraz | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Amitraz. |
| Medetomidine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Medetomidine. |
| Xylazine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Xylazine. |
| Atipamezole | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Atipamezole. |
| Ractopamine | The risk or severity of hypertension can be increased when Phenylbutazone is combined with Ractopamine. |