Peringatan Keamanan

Oral LD50 is 865 mg/kg in rats and 565 mg/kg in mice. Intraperitoneal LD50 is 1210 mg/kg in rats and 695 mg/kg in mice. Subcutaneous LD50 is 872 mg/kg in rats and 665 mg/kg in mice.L32183

There is limited information on tropicamide overdose. Systemic adverse effects, such as tachycardia, central nervous system disturbances, and muscle rigidity have been reported with the use of tropicamide. Psychotic reactions, behavioral disturbances, and vasomotor or cardio-respiratory collapse have been reported with the use of anticholinergic in children.L32103

Tropicamide

DB00809

small molecule approved investigational

Deskripsi

Tropicamide is an alkaloid atropine?derived anticholinergic drug and a non?selective antagonist of muscarinic acetylcholine (mACh) receptors.A230103 Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures.A229958 It is also used in combination with hydroxyamphetamine for the same indication.L32178 Oral tropicamide has been investigated as a potential drug to relieve sialorrhea in patients with Parkinson's Disease.A229958

Struktur Molekul 2D

Berat 284.3529
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Tropicamide has a plasma half-life of 30?minutes.[A230093]
Volume Distribusi No information can be found.
Klirens (Clearance) No information can be found.

Absorpsi

Following ocular administration of 40 ?L drops of 0.5% tropicamide in female subjects, tropicamide reached its mean peak concentration in plasma of 2.8 ± 1.7 ng/mL (mean ± SD) at five minutes.A230173

Metabolisme

No information can be found.

Rute Eliminasi

No information can be found.

Interaksi Obat

230 Data
Tramadol The risk or severity of adverse effects can be increased when Tramadol is combined with Tropicamide.
Trospium The risk or severity of adverse effects can be increased when Trospium is combined with Tropicamide.
Oxyphenonium The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Tropicamide.
Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Tropicamide.
Butalbital The risk or severity of adverse effects can be increased when Butalbital is combined with Tropicamide.
Benzatropine The risk or severity of adverse effects can be increased when Benzatropine is combined with Tropicamide.
Ziprasidone The risk or severity of adverse effects can be increased when Ziprasidone is combined with Tropicamide.
Disopyramide The risk or severity of adverse effects can be increased when Disopyramide is combined with Tropicamide.
Talbutal The risk or severity of adverse effects can be increased when Talbutal is combined with Tropicamide.
Pentobarbital The risk or severity of adverse effects can be increased when Pentobarbital is combined with Tropicamide.
Amitriptyline The risk or severity of adverse effects can be increased when Amitriptyline is combined with Tropicamide.
Ipratropium The risk or severity of adverse effects can be increased when Ipratropium is combined with Tropicamide.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Tropicamide.
Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Tropicamide.
Metixene The risk or severity of adverse effects can be increased when Metixene is combined with Tropicamide.
Terfenadine The risk or severity of adverse effects can be increased when Terfenadine is combined with Tropicamide.
Buclizine The risk or severity of adverse effects can be increased when Buclizine is combined with Tropicamide.
Clozapine The risk or severity of reduced gastrointestinal motility can be increased when Tropicamide is combined with Clozapine.
Doxylamine The risk or severity of adverse effects can be increased when Doxylamine is combined with Tropicamide.
Trihexyphenidyl The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Tropicamide.
Oxyphencyclimine The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Tropicamide.
Procyclidine The risk or severity of adverse effects can be increased when Procyclidine is combined with Tropicamide.
Profenamine The risk or severity of adverse effects can be increased when Profenamine is combined with Tropicamide.
Metocurine iodide The risk or severity of adverse effects can be increased when Metocurine iodide is combined with Tropicamide.
Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Tropicamide.
Promazine The risk or severity of adverse effects can be increased when Promazine is combined with Tropicamide.
Hyoscyamine The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Tropicamide.
Cyproheptadine The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Tropicamide.
Imipramine The risk or severity of adverse effects can be increased when Imipramine is combined with Tropicamide.
Methscopolamine bromide The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Tropicamide.
Metharbital The risk or severity of adverse effects can be increased when Metharbital is combined with Tropicamide.
Fluoxetine The risk or severity of adverse effects can be increased when Fluoxetine is combined with Tropicamide.
Chlorpromazine The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Tropicamide.
Gallamine triethiodide The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Tropicamide.
Darifenacin The risk or severity of adverse effects can be increased when Darifenacin is combined with Tropicamide.
Tridihexethyl The risk or severity of adverse effects can be increased when Tridihexethyl is combined with Tropicamide.
Triflupromazine The risk or severity of adverse effects can be increased when Triflupromazine is combined with Tropicamide.
Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Tropicamide.
Anisotropine methylbromide The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Tropicamide.
Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Tropicamide.
Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Tropicamide.
Cisatracurium The risk or severity of adverse effects can be increased when Cisatracurium is combined with Tropicamide.
Atropine The risk or severity of adverse effects can be increased when Atropine is combined with Tropicamide.
Thiopental The risk or severity of adverse effects can be increased when Thiopental is combined with Tropicamide.
Nicardipine The risk or severity of adverse effects can be increased when Nicardipine is combined with Tropicamide.
Mecamylamine The risk or severity of adverse effects can be increased when Mecamylamine is combined with Tropicamide.
Pirenzepine The risk or severity of adverse effects can be increased when Pirenzepine is combined with Tropicamide.
Paroxetine The risk or severity of adverse effects can be increased when Paroxetine is combined with Tropicamide.
Procaine The risk or severity of adverse effects can be increased when Procaine is combined with Tropicamide.
Homatropine methylbromide The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Tropicamide.
Rocuronium The risk or severity of adverse effects can be increased when Rocuronium is combined with Tropicamide.
Atracurium besylate The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Tropicamide.
Scopolamine The risk or severity of adverse effects can be increased when Scopolamine is combined with Tropicamide.
Isoflurane The risk or severity of adverse effects can be increased when Isoflurane is combined with Tropicamide.
Benzquinamide The risk or severity of adverse effects can be increased when Benzquinamide is combined with Tropicamide.
Clidinium The risk or severity of adverse effects can be increased when Clidinium is combined with Tropicamide.
Propiomazine The risk or severity of adverse effects can be increased when Propiomazine is combined with Tropicamide.
Propantheline The risk or severity of adverse effects can be increased when Propantheline is combined with Tropicamide.
Primidone The risk or severity of adverse effects can be increased when Primidone is combined with Tropicamide.
Dicyclomine The risk or severity of adverse effects can be increased when Dicyclomine is combined with Tropicamide.
Biperiden The risk or severity of adverse effects can be increased when Tropicamide is combined with Biperiden.
Brompheniramine The risk or severity of adverse effects can be increased when Tropicamide is combined with Brompheniramine.
Methylphenobarbital The risk or severity of adverse effects can be increased when Tropicamide is combined with Methylphenobarbital.
Cocaine The risk or severity of adverse effects can be increased when Tropicamide is combined with Cocaine.
Quinidine The risk or severity of adverse effects can be increased when Tropicamide is combined with Quinidine.
Amantadine The risk or severity of adverse effects can be increased when Tropicamide is combined with Amantadine.
Maprotiline The risk or severity of adverse effects can be increased when Tropicamide is combined with Maprotiline.
Methantheline The risk or severity of adverse effects can be increased when Tropicamide is combined with Methantheline.
Hexafluronium The risk or severity of adverse effects can be increased when Tropicamide is combined with Hexafluronium.
Cycrimine The risk or severity of adverse effects can be increased when Tropicamide is combined with Cycrimine.
Desloratadine The risk or severity of adverse effects can be increased when Tropicamide is combined with Desloratadine.
Cyclopentolate The risk or severity of adverse effects can be increased when Tropicamide is combined with Cyclopentolate.
Glycopyrronium The risk or severity of adverse effects can be increased when Tropicamide is combined with Glycopyrronium.
Tolterodine The risk or severity of adverse effects can be increased when Tropicamide is combined with Tolterodine.
Oxybutynin The risk or severity of adverse effects can be increased when Tropicamide is combined with Oxybutynin.
Promethazine The risk or severity of adverse effects can be increased when Tropicamide is combined with Promethazine.
Diphenhydramine The risk or severity of adverse effects can be increased when Tropicamide is combined with Diphenhydramine.
Pentolinium The risk or severity of adverse effects can be increased when Tropicamide is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Tropicamide is combined with Trimethaphan.
Doxacurium The risk or severity of adverse effects can be increased when Tropicamide is combined with Doxacurium.
Doxepin The risk or severity of adverse effects can be increased when Tropicamide is combined with Doxepin.
Flavoxate The risk or severity of adverse effects can be increased when Tropicamide is combined with Flavoxate.
Desipramine The risk or severity of adverse effects can be increased when Tropicamide is combined with Desipramine.
Orphenadrine The risk or severity of adverse effects can be increased when Tropicamide is combined with Orphenadrine.
Phenobarbital The risk or severity of adverse effects can be increased when Tropicamide is combined with Phenobarbital.
Escitalopram The risk or severity of adverse effects can be increased when Tropicamide is combined with Escitalopram.
Tubocurarine The risk or severity of adverse effects can be increased when Tropicamide is combined with Tubocurarine.
Quetiapine The risk or severity of adverse effects can be increased when Tropicamide is combined with Quetiapine.
Mivacurium The risk or severity of adverse effects can be increased when Tropicamide is combined with Mivacurium.
Levacetylmethadol The risk or severity of adverse effects can be increased when Tropicamide is combined with Levacetylmethadol.
Diphenidol The risk or severity of adverse effects can be increased when Tropicamide is combined with Diphenidol.
Aripiprazole The risk or severity of adverse effects can be increased when Tropicamide is combined with Aripiprazole.
Chlorprothixene The risk or severity of adverse effects can be increased when Tropicamide is combined with Chlorprothixene.
Fenoterol The risk or severity of adverse effects can be increased when Tropicamide is combined with Fenoterol.
Metocurine The risk or severity of adverse effects can be increased when Tropicamide is combined with Metocurine.
Pancuronium The risk or severity of adverse effects can be increased when Tropicamide is combined with Pancuronium.
Pipecuronium The risk or severity of adverse effects can be increased when Tropicamide is combined with Pipecuronium.
Vecuronium The risk or severity of adverse effects can be increased when Tropicamide is combined with Vecuronium.
Amobarbital The risk or severity of adverse effects can be increased when Tropicamide is combined with Amobarbital.
Aprobarbital The risk or severity of adverse effects can be increased when Tropicamide is combined with Aprobarbital.

Target Protein

Muscarinic acetylcholine receptor M4 CHRM4
Muscarinic acetylcholine receptor M1 CHRM1
Muscarinic acetylcholine receptor M2 CHRM2
Muscarinic acetylcholine receptor M3 CHRM3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 31082113
    Hong D, Tripathy K: Tropicamide .
  • PMID: -
    Kilic O, Ozturk M, Gozcelioglu EA: Tropicamide ophthalmic solution reduces clozapine-induced sialorrhea: a case report Psychiatry and Clinical Psychopharmacology. 2017 Jul 8;27(4):431-434.
  • PMID: 16700815
    Mouly S, Mahe I, Haouchine B, Sanson-le-Pors MJ, Blain P, Tillet Y, Dewailly J, Mongold JJ, Bergmann JF: Pharmacodynamics of a new ophthalmic mydriatic insert in healthy volunteers: potential alternative as drug delivery system prior to cataract surgery. Basic Clin Pharmacol Toxicol. 2006 Jun;98(6):547-54. doi: 10.1111/j.1742-7843.2006.pto_362.x.
  • PMID: 17594079
    Betz AJ, McLaughlin PJ, Burgos M, Weber SM, Salamone JD: The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. Psychopharmacology (Berl). 2007 Oct;194(3):347-59. Epub 2007 Jun 27.
  • PMID: 8083562
    Vuori ML, Kaila T, Iisalo E, Saari KM: Systemic absorption and anticholinergic activity of topically applied tropicamide. J Ocul Pharmacol. 1994 Summer;10(2):431-7. doi: 10.1089/jop.1994.10.431.
  • PMID: -
    Broadley KJ, Kelly DR: Muscarinic Receptor Agonists and Antagonists Molecules. 2001 Feb 28;6(3):142-193.
  • PMID: 25589275
    McDougal DH, Gamlin PD: Autonomic control of the eye. Compr Physiol. 2015 Jan;5(1):439-73. doi: 10.1002/cphy.c140014.
  • PMID: 32047429
    Sebbag L, Moody LM, Mochel JP: Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs. Front Pharmacol. 2020 Jan 28;10:1560. doi: 10.3389/fphar.2019.01560. eCollection 2019.

Contoh Produk & Brand

Produk: 31 • International brands: 15
Produk
  • Diophenyl-T Solution
    Solution • - • Ophthalmic • Canada • Approved
  • Minims Tropicamide
    Solution / drops • 1 % w/v • Ophthalmic • Canada • Approved
  • Mydcombi
    Spray, metered • - • Ophthalmic • US • Approved
  • Mydriacyl
    Solution • 5 mg/1mL • Ophthalmic • US • Generic • Approved
  • Mydriacyl
    Solution / drops • 10 mg/1mL • Ophthalmic • US • Generic • Approved
  • Mydriacyl
    Solution / drops • 10 mg/1mL • Ophthalmic • US • Generic • Approved
  • Mydriacyl
    Solution • 0.5 % w/v • Ophthalmic • Canada • Approved
  • Mydriacyl
    Solution • 1 % w/v • Ophthalmic • Canada • Approved
Menampilkan 8 dari 31 produk.
International Brands
  • Better — Taiwan Biotech
  • Camide — Ibn Sina
  • Ciclomidrin — Latinofarma
  • Dilate — Incepta
  • Eyetrop — Apex
  • Losemin — Oasis
  • Midax — Rompharm
  • Midric — Sanbe
  • Minims Tropicamide — Bausch & Lomb
  • Mydral — Ocusoft

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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