Minaprine

DB00805

small molecule approved

Deskripsi

Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.

Struktur Molekul 2D

Berat 298.3828
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1615 Data
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Magnesium sulfate The therapeutic efficacy of Minaprine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Minaprine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Minaprine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Orphenadrine Minaprine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Minaprine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Minaprine.
Pramipexole Minaprine may increase the sedative activities of Pramipexole.
Ropinirole Minaprine may increase the sedative activities of Ropinirole.
Rotigotine Minaprine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Minaprine.
Sodium oxybate Minaprine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Minaprine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Minaprine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Minaprine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Desmopressin The risk or severity of hypertension can be increased when Desmopressin is combined with Minaprine.
Icosapent The risk or severity of hypertension can be increased when Icosapent is combined with Minaprine.
Mesalazine The risk or severity of hypertension can be increased when Mesalazine is combined with Minaprine.
Indomethacin The risk or severity of hypertension can be increased when Indomethacin is combined with Minaprine.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Minaprine.
Nabumetone The risk or severity of hypertension can be increased when Nabumetone is combined with Minaprine.
Ketorolac The risk or severity of hypertension can be increased when Ketorolac is combined with Minaprine.
Tenoxicam The risk or severity of hypertension can be increased when Tenoxicam is combined with Minaprine.
Tolmetin The risk or severity of hypertension can be increased when Tolmetin is combined with Minaprine.
Rofecoxib The risk or severity of hypertension can be increased when Rofecoxib is combined with Minaprine.
Piroxicam The risk or severity of hypertension can be increased when Piroxicam is combined with Minaprine.
Fenoprofen The risk or severity of hypertension can be increased when Fenoprofen is combined with Minaprine.
Valdecoxib The risk or severity of hypertension can be increased when Valdecoxib is combined with Minaprine.
Diclofenac The risk or severity of hypertension can be increased when Diclofenac is combined with Minaprine.
Sulindac The risk or severity of hypertension can be increased when Sulindac is combined with Minaprine.
Flurbiprofen The risk or severity of hypertension can be increased when Flurbiprofen is combined with Minaprine.
Etodolac The risk or severity of hypertension can be increased when Etodolac is combined with Minaprine.
Mefenamic acid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Minaprine.
Naproxen The risk or severity of hypertension can be increased when Naproxen is combined with Minaprine.
Sulfasalazine The risk or severity of hypertension can be increased when Sulfasalazine is combined with Minaprine.
Phenylbutazone The risk or severity of hypertension can be increased when Minaprine is combined with Phenylbutazone.
Meloxicam The risk or severity of hypertension can be increased when Minaprine is combined with Meloxicam.
Carprofen The risk or severity of hypertension can be increased when Minaprine is combined with Carprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Minaprine is combined with Phenmetrazine.
Diflunisal The risk or severity of hypertension can be increased when Minaprine is combined with Diflunisal.
Salicylic acid The risk or severity of hypertension can be increased when Minaprine is combined with Salicylic acid.
Meclofenamic acid The risk or severity of hypertension can be increased when Minaprine is combined with Meclofenamic acid.
Oxaprozin The risk or severity of hypertension can be increased when Minaprine is combined with Oxaprozin.
Ketoprofen The risk or severity of hypertension can be increased when Minaprine is combined with Ketoprofen.
Balsalazide The risk or severity of hypertension can be increased when Minaprine is combined with Balsalazide.
Ibuprofen The risk or severity of hypertension can be increased when Minaprine is combined with Ibuprofen.
Dutasteride The risk or severity of hypertension can be increased when Minaprine is combined with Dutasteride.
Finasteride The risk or severity of hypertension can be increased when Minaprine is combined with Finasteride.
Lumiracoxib The risk or severity of hypertension can be increased when Minaprine is combined with Lumiracoxib.
Magnesium salicylate The risk or severity of hypertension can be increased when Minaprine is combined with Magnesium salicylate.
Salsalate The risk or severity of hypertension can be increased when Minaprine is combined with Salsalate.
Choline magnesium trisalicylate The risk or severity of hypertension can be increased when Minaprine is combined with Choline magnesium trisalicylate.
Antrafenine The risk or severity of hypertension can be increased when Minaprine is combined with Antrafenine.
Tiaprofenic acid The risk or severity of hypertension can be increased when Minaprine is combined with Tiaprofenic acid.
Epicaptopril The risk or severity of hypertension can be increased when Minaprine is combined with Epicaptopril.
Taxifolin The risk or severity of hypertension can be increased when Minaprine is combined with Taxifolin.
Oxyphenbutazone The risk or severity of hypertension can be increased when Minaprine is combined with Oxyphenbutazone.
1-benzylimidazole The risk or severity of hypertension can be increased when Minaprine is combined with 1-benzylimidazole.
Benoxaprofen The risk or severity of hypertension can be increased when Minaprine is combined with Benoxaprofen.
Metamizole The risk or severity of hypertension can be increased when Minaprine is combined with Metamizole.
Zomepirac The risk or severity of hypertension can be increased when Minaprine is combined with Zomepirac.
Cimicoxib The risk or severity of hypertension can be increased when Minaprine is combined with Cimicoxib.
Amibegron The risk or severity of hypertension can be increased when Minaprine is combined with Amibegron.
Nylidrin The risk or severity of hypertension can be increased when Minaprine is combined with Nylidrin.
Solabegron The risk or severity of hypertension can be increased when Minaprine is combined with Solabegron.
Lornoxicam The risk or severity of hypertension can be increased when Minaprine is combined with Lornoxicam.
Aceclofenac The risk or severity of hypertension can be increased when Minaprine is combined with Aceclofenac.
Zaltoprofen The risk or severity of hypertension can be increased when Minaprine is combined with Zaltoprofen.
Saralasin The risk or severity of hypertension can be increased when Minaprine is combined with Saralasin.
Azapropazone The risk or severity of hypertension can be increased when Minaprine is combined with Azapropazone.
Parecoxib The risk or severity of hypertension can be increased when Minaprine is combined with Parecoxib.
Salicylamide The risk or severity of hypertension can be increased when Minaprine is combined with Salicylamide.
Tyramine The risk or severity of hypertension can be increased when Minaprine is combined with Tyramine.
Adrafinil The risk or severity of hypertension can be increased when Minaprine is combined with Adrafinil.
Kebuzone The risk or severity of hypertension can be increased when Minaprine is combined with Kebuzone.
Isoxicam The risk or severity of hypertension can be increased when Minaprine is combined with Isoxicam.
Indoprofen The risk or severity of hypertension can be increased when Minaprine is combined with Indoprofen.
Ibuproxam The risk or severity of hypertension can be increased when Minaprine is combined with Ibuproxam.
Floctafenine The risk or severity of hypertension can be increased when Minaprine is combined with Floctafenine.
Fenbufen The risk or severity of hypertension can be increased when Minaprine is combined with Fenbufen.
Etofenamate The risk or severity of hypertension can be increased when Minaprine is combined with Etofenamate.
Etilefrine The risk or severity of hypertension can be increased when Minaprine is combined with Etilefrine.
Epirizole The risk or severity of hypertension can be increased when Minaprine is combined with Epirizole.
Benzydamine The risk or severity of hypertension can be increased when Minaprine is combined with Benzydamine.
Synephrine The risk or severity of hypertension can be increased when Minaprine is combined with Synephrine.
Dexibuprofen The risk or severity of hypertension can be increased when Minaprine is combined with Dexibuprofen.
Dexketoprofen The risk or severity of hypertension can be increased when Minaprine is combined with Dexketoprofen.
Droxicam The risk or severity of hypertension can be increased when Minaprine is combined with Droxicam.
Tolfenamic acid The risk or severity of hypertension can be increased when Minaprine is combined with Tolfenamic acid.
Firocoxib The risk or severity of hypertension can be increased when Minaprine is combined with Firocoxib.
Clonixin The risk or severity of hypertension can be increased when Minaprine is combined with Clonixin.
Morniflumate The risk or severity of hypertension can be increased when Minaprine is combined with Morniflumate.
Talniflumate The risk or severity of hypertension can be increased when Minaprine is combined with Talniflumate.
Dihydroergocornine The risk or severity of hypertension can be increased when Minaprine is combined with Dihydroergocornine.
DL-Methylephedrine The risk or severity of hypertension can be increased when Minaprine is combined with DL-Methylephedrine.

Target Protein

Amine oxidase [flavin-containing] A MAOA
5-hydroxytryptamine receptor 2B HTR2B
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
Acetylcholinesterase ACHE
Sodium-dependent serotonin transporter SLC6A4
D(1A) dopamine receptor DRD1
D(2) dopamine receptor DRD2
Muscarinic acetylcholine receptor M1 CHRM1

Referensi & Sumber

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Contoh Produk & Brand

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International Brands
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