Peringatan Keamanan

Symptoms of overexposure include characteristic rigidity of the skeletal muscles, cardiac and respiratory depression, and narrowing of the pupils.

Alfentanil

DB00802

small molecule approved illicit

Deskripsi

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.

Struktur Molekul 2D

Berat 416.5172
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 90-111 minutes
Volume Distribusi * 0.4 to 1 L/kg
Klirens (Clearance) * 5 mL/kg/min

Absorpsi

For intravenous injection or infusion only.

Metabolisme

The liver is the major site of biotransformation.

Rute Eliminasi

Only 1.0% of the dose is excreted as unchanged drug; urinary excretion is the major route of elimination of metabolites.

Interaksi Obat

1582 Data
Ceritinib Alfentanil may increase the bradycardic activities of Ceritinib.
Ivabradine Alfentanil may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Alfentanil.
Valsartan Alfentanil may decrease the antihypertensive activities of Valsartan.
Ramipril Alfentanil may decrease the antihypertensive activities of Ramipril.
Remikiren Alfentanil may decrease the antihypertensive activities of Remikiren.
Guanadrel Alfentanil may decrease the antihypertensive activities of Guanadrel.
Olmesartan Alfentanil may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Alfentanil may decrease the antihypertensive activities of Nitroprusside.
Atenolol Alfentanil may decrease the antihypertensive activities of Atenolol.
Minoxidil Alfentanil may decrease the antihypertensive activities of Minoxidil.
Treprostinil Alfentanil may decrease the antihypertensive activities of Treprostinil.
Fosinopril Alfentanil may decrease the antihypertensive activities of Fosinopril.
Trandolapril Alfentanil may decrease the antihypertensive activities of Trandolapril.
Benazepril Alfentanil may decrease the antihypertensive activities of Benazepril.
Candoxatril Alfentanil may decrease the antihypertensive activities of Candoxatril.
Moexipril Alfentanil may decrease the antihypertensive activities of Moexipril.
Lisinopril Alfentanil may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Alfentanil may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Alfentanil may decrease the antihypertensive activities of Cryptenamine.
Perindopril Alfentanil may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Alfentanil may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Alfentanil may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Alfentanil may decrease the antihypertensive activities of Eprosartan.
Quinapril Alfentanil may decrease the antihypertensive activities of Quinapril.
Telmisartan Alfentanil may decrease the antihypertensive activities of Telmisartan.
Deserpidine Alfentanil may decrease the antihypertensive activities of Deserpidine.
Terazosin Alfentanil may decrease the antihypertensive activities of Terazosin.
Captopril Alfentanil may decrease the antihypertensive activities of Captopril.
Epoprostenol Alfentanil may decrease the antihypertensive activities of Epoprostenol.
Cilazapril Alfentanil may decrease the antihypertensive activities of Cilazapril.
Saprisartan Alfentanil may decrease the antihypertensive activities of Saprisartan.
Spirapril Alfentanil may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Alfentanil may decrease the antihypertensive activities of Dexpropranolol.
Diethylnorspermine Alfentanil may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Alfentanil may decrease the antihypertensive activities of Temocapril.
Trimazosin Alfentanil may decrease the antihypertensive activities of Trimazosin.
Nicorandil Alfentanil may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Alfentanil may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Alfentanil may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Alfentanil may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Alfentanil may decrease the antihypertensive activities of Imidapril.
BQ-123 Alfentanil may decrease the antihypertensive activities of BQ-123.
Dihydralazine Alfentanil may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Alfentanil may decrease the antihypertensive activities of Zofenopril.
Guanoxan Alfentanil may decrease the antihypertensive activities of Guanoxan.
Delapril Alfentanil may decrease the antihypertensive activities of Delapril.
Vincamine Alfentanil may decrease the antihypertensive activities of Vincamine.
Linsidomine Alfentanil may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Alfentanil may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Alfentanil may decrease the antihypertensive activities of Tolonidine.
Endralazine Alfentanil may decrease the antihypertensive activities of Endralazine.
Cadralazine Alfentanil may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Alfentanil may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Alfentanil may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Alfentanil may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Alfentanil may decrease the antihypertensive activities of Guanoclor.
Candesartan Alfentanil may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Alfentanil may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Alfentanil may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Alfentanil may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Alfentanil may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Alfentanil may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Alfentanil may decrease the antihypertensive activities of Quinaprilat.
Enalapril Alfentanil may decrease the antihypertensive activities of Enalapril.
Nimodipine Alfentanil may decrease the antihypertensive activities of Nimodipine.
Carvedilol Alfentanil may decrease the antihypertensive activities of Carvedilol.
Guanethidine Alfentanil may decrease the antihypertensive activities of Guanethidine.
Bepridil Alfentanil may decrease the antihypertensive activities of Bepridil.
Nebivolol Alfentanil may decrease the antihypertensive activities of Nebivolol.
Pinacidil Alfentanil may decrease the antihypertensive activities of Pinacidil.
Riociguat Alfentanil may decrease the antihypertensive activities of Riociguat.
Macitentan Alfentanil may decrease the antihypertensive activities of Macitentan.
Aliskiren Alfentanil may decrease the antihypertensive activities of Aliskiren.
Lacidipine Alfentanil may decrease the antihypertensive activities of Lacidipine.
Niguldipine Alfentanil may decrease the antihypertensive activities of Niguldipine.
Naftopidil Alfentanil may decrease the antihypertensive activities of Naftopidil.
Dexniguldipine Alfentanil may decrease the antihypertensive activities of Dexniguldipine.
Timolol Alfentanil may decrease the antihypertensive activities of Timolol.
Prazosin Alfentanil may decrease the antihypertensive activities of Prazosin.
Bisoprolol Alfentanil may decrease the antihypertensive activities of Bisoprolol.
Acebutolol Alfentanil may decrease the antihypertensive activities of Acebutolol.
Nadolol Alfentanil may decrease the antihypertensive activities of Nadolol.
Debrisoquine Alfentanil may decrease the antihypertensive activities of Debrisoquine.
Celiprolol Alfentanil may decrease the antihypertensive activities of Celiprolol.
Selexipag Alfentanil may decrease the antihypertensive activities of Selexipag.
Talinolol Alfentanil may decrease the antihypertensive activities of Talinolol.
Amlodipine Alfentanil may decrease the antihypertensive activities of Amlodipine.
Metoprolol Alfentanil may decrease the antihypertensive activities of Metoprolol.
Nisoldipine Alfentanil may decrease the antihypertensive activities of Nisoldipine.
Lercanidipine Alfentanil may decrease the antihypertensive activities of Lercanidipine.
Bosentan Alfentanil may decrease the antihypertensive activities of Bosentan.
Propranolol Alfentanil may decrease the antihypertensive activities of Propranolol.
Doxazosin Alfentanil may decrease the antihypertensive activities of Doxazosin.
Losartan Alfentanil may decrease the antihypertensive activities of Losartan.
Tadalafil Alfentanil may decrease the antihypertensive activities of Tadalafil.
Felodipine Alfentanil may decrease the antihypertensive activities of Felodipine.
Irbesartan Alfentanil may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Alfentanil may decrease the antihypertensive activities of Nitrendipine.
Hydralazine Alfentanil may decrease the antihypertensive activities of Hydralazine.

Target Protein

Mu-type opioid receptor OPRM1

Referensi & Sumber

Synthesis reference: Jacob Mathew, J. Killgore, "New methods for the synthesis of alfentanil, sufentanil, and remifentanil." U.S. Patent US20060149071, issued July 06, 2006.

Contoh Produk & Brand

Produk: 6 • International brands: 1
Produk
  • Alfenta
    Injection • 500 ug/1mL • Intravenous • US • Approved
  • Alfenta Inj 500mcg/ml
    Solution • 500 mcg / mL • Intravenous • Canada • Approved
  • Alfentanil
    Injection • 500 ug/1mL • Intravenous • US • Approved
  • Alfentanil Hydrochloride
    Injection • 500 ug/1mL • Intravenous • US • Approved
  • Alfentanil Hydrochloride
    Injection, solution • 500 ug/1mL • Intravenous • US • Generic • Approved
  • Alfentanil Injection USP
    Solution • 500 mcg / mL • Intravenous • Canada • Approved
International Brands
  • Rapifen — Janssen

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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