Halazepam

DB00801

small molecule approved illicit withdrawn

Deskripsi

Halazepam is a benzodiazepine derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.A1212, A178114 It has been shown to be less toxic than chlordiazepoxide or diazepam.A1212 This drug is no longer marketed in the United States, and was withdrawn by Schering, its manufacturer, in 2009.L6226, L6229

Struktur Molekul 2D

Berat 352.738
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

715 Data
Buprenorphine Halazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Hydrocodone Halazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Magnesium sulfate The therapeutic efficacy of Halazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Halazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Halazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Mirtazapine Halazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Orphenadrine Halazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Halazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Pramipexole Halazepam may increase the sedative activities of Pramipexole.
Ropinirole Halazepam may increase the sedative activities of Ropinirole.
Rotigotine Halazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Halazepam.
Suvorexant Halazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Thalidomide Halazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Halazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Clozapine The risk or severity of adverse effects can be increased when Halazepam is combined with Clozapine.
Methadone Halazepam may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Olanzapine The risk or severity of adverse effects can be increased when Halazepam is combined with Olanzapine.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Halazepam.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Halazepam.
Sodium oxybate Halazepam may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Teduglutide The serum concentration of Halazepam can be increased when it is combined with Teduglutide.
Yohimbine The therapeutic efficacy of Halazepam can be increased when used in combination with Yohimbine.
Ethanol Halazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Halazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Zimelidine The risk or severity of adverse effects can be increased when Halazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Halazepam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Halazepam is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Halazepam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Halazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Halazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Halazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Halazepam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Halazepam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Halazepam is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Halazepam is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Halazepam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Halazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Halazepam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Halazepam is combined with Levomilnacipran.
Indalpine The risk or severity of adverse effects can be increased when Halazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Halazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Halazepam is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Halazepam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Halazepam.
Zopiclone The risk or severity of adverse effects can be increased when Halazepam is combined with Zopiclone.
Caffeine The therapeutic efficacy of Halazepam can be decreased when used in combination with Caffeine.
Theophylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Theophylline.
Dyphylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Dyphylline.
Pentoxifylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Pentoxifylline.
Mercaptopurine The therapeutic efficacy of Halazepam can be decreased when used in combination with Mercaptopurine.
Aminophylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Aminophylline.
Oxtriphylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Oxtriphylline.
Theobromine The therapeutic efficacy of Halazepam can be decreased when used in combination with Theobromine.
Fenethylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Fenethylline.
8-azaguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 8-azaguanine.
7,9-Dimethylguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 7,9-Dimethylguanine.
Xanthine The therapeutic efficacy of Halazepam can be decreased when used in combination with Xanthine.
7-Deazaguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 7-Deazaguanine.
Guanine The therapeutic efficacy of Halazepam can be decreased when used in combination with Guanine.
9-Methylguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 9-Methylguanine.
Peldesine The therapeutic efficacy of Halazepam can be decreased when used in combination with Peldesine.
Hypoxanthine The therapeutic efficacy of Halazepam can be decreased when used in combination with Hypoxanthine.
9-Deazaguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 9-Deazaguanine.
Propentofylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Propentofylline.
Valomaciclovir The therapeutic efficacy of Halazepam can be decreased when used in combination with Valomaciclovir.
3-isobutyl-1-methyl-7H-xanthine The therapeutic efficacy of Halazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
Uric acid The therapeutic efficacy of Halazepam can be decreased when used in combination with Uric acid.
Doxofylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Doxofylline.
6-O-benzylguanine The therapeutic efficacy of Halazepam can be decreased when used in combination with 6-O-benzylguanine.
Lisofylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Lisofylline.
Lobucavir The therapeutic efficacy of Halazepam can be decreased when used in combination with Lobucavir.
Cafedrine The therapeutic efficacy of Halazepam can be decreased when used in combination with Cafedrine.
Theodrenaline The therapeutic efficacy of Halazepam can be decreased when used in combination with Theodrenaline.
Bamifylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Bamifylline.
Proxyphylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Proxyphylline.
Acefylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Acefylline.
Etamiphylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Etamiphylline.
Pentifylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Pentifylline.
Bufylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Bufylline.
Bromotheophylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Bromotheophylline.
Furafylline The therapeutic efficacy of Halazepam can be decreased when used in combination with Furafylline.
8-chlorotheophylline The therapeutic efficacy of Halazepam can be decreased when used in combination with 8-chlorotheophylline.
PCS-499 The therapeutic efficacy of Halazepam can be decreased when used in combination with PCS-499.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Halazepam.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Halazepam.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Halazepam.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Halazepam.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Halazepam.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Halazepam.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Halazepam.

Target Protein

Translocator protein TSPO
GABA(A) Receptor GABRA1
GABA(A) Receptor Benzodiazepine Binding Site GABRA1

Referensi & Sumber

Synthesis reference: U.S. Patents 3,429,874 and 3,641,147.
Artikel (PubMed)
  • PMID: 6152591
    Fann WE, Pitts WM, Wheless JC: Pharmacology, efficacy, and adverse effects of halazepam, a new benzodiazepine. Pharmacotherapy. 1982 Mar-Apr;2(2):72-9.
  • PMID: 22258993
    Richards BL, Whittle SL, Buchbinder R: Muscle relaxants for pain management in rheumatoid arthritis. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2.

Contoh Produk & Brand

Produk: 0 • International brands: 3
International Brands
  • Alapryl — Menarini
  • Pacinone — Schering-Plough
  • Paxipam — Schering-Plough

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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