Peringatan Keamanan

The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures.

Fenoldopam

DB00800

small molecule approved

Deskripsi

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.

Struktur Molekul 2D

Berat 305.756
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Methylation, glucuronidation, and sulfation are the main routes of conjugation.

Rute Eliminasi

Radiolabeled studies show that about 90% of infused fenoldopam is eliminated in urine, 10% in feces. Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Only 4% of the administered dose is excreted unchanged.

Interaksi Makanan

1 Data
  • 1. Take on an empty stomach. Orally administered fenoldopam should be taken in a fasted state for optimal absorption.

Interaksi Obat

1188 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Fenoldopam is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Fenoldopam is combined with Levodopa.
Risperidone Fenoldopam may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Fenoldopam.
Amifostine Fenoldopam may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Fenoldopam.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Fenoldopam.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Fenoldopam.
Obinutuzumab Fenoldopam may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Fenoldopam.
Rituximab Fenoldopam may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Fenoldopam.
Midodrine Midodrine may decrease the antihypertensive activities of Fenoldopam.
Eletriptan Eletriptan may decrease the antihypertensive activities of Fenoldopam.
Isoetharine Isoetharine may decrease the antihypertensive activities of Fenoldopam.
Methysergide Methysergide may decrease the antihypertensive activities of Fenoldopam.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Fenoldopam.
Protriptyline Protriptyline may decrease the antihypertensive activities of Fenoldopam.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Fenoldopam.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Fenoldopam.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Fenoldopam.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Fenoldopam.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Fenoldopam.
Doxapram Doxapram may decrease the antihypertensive activities of Fenoldopam.
Atropine Atropine may decrease the antihypertensive activities of Fenoldopam.
Metaraminol Metaraminol may decrease the antihypertensive activities of Fenoldopam.
Trazodone Trazodone may decrease the antihypertensive activities of Fenoldopam.
Epinephrine Epinephrine may decrease the antihypertensive activities of Fenoldopam.
Ergotamine Ergotamine may decrease the antihypertensive activities of Fenoldopam.
Nicergoline Nicergoline may decrease the antihypertensive activities of Fenoldopam.
Methoxamine Methoxamine may decrease the antihypertensive activities of Fenoldopam.
Trimipramine Trimipramine may decrease the antihypertensive activities of Fenoldopam.
Alfentanil Alfentanil may decrease the antihypertensive activities of Fenoldopam.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Fenoldopam.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Fenoldopam.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Fenoldopam.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Fenoldopam.
Ritodrine Ritodrine may decrease the antihypertensive activities of Fenoldopam.
Bitolterol Bitolterol may decrease the antihypertensive activities of Fenoldopam.
Oxymetazoline Oxymetazoline may decrease the antihypertensive activities of Fenoldopam.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Fenoldopam.
Salmeterol Salmeterol may decrease the antihypertensive activities of Fenoldopam.
Naratriptan Naratriptan may decrease the antihypertensive activities of Fenoldopam.
Formoterol Formoterol may decrease the antihypertensive activities of Fenoldopam.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Fenoldopam.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Fenoldopam.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Fenoldopam.
Arbutamine Arbutamine may decrease the antihypertensive activities of Fenoldopam.
Dutasteride Dutasteride may decrease the antihypertensive activities of Fenoldopam.
Propafenone Propafenone may decrease the antihypertensive activities of Fenoldopam.
Finasteride Finasteride may decrease the antihypertensive activities of Fenoldopam.
Ergometrine Ergometrine may decrease the antihypertensive activities of Fenoldopam.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Fenoldopam.
Fenoterol Fenoterol may decrease the antihypertensive activities of Fenoldopam.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Fenoldopam.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Fenoldopam.
Ephedrine Ephedrine may decrease the antihypertensive activities of Fenoldopam.
Mephentermine Mephentermine may decrease the antihypertensive activities of Fenoldopam.
Procaterol Procaterol may decrease the antihypertensive activities of Fenoldopam.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Fenoldopam.
Bambuterol Bambuterol may decrease the antihypertensive activities of Fenoldopam.
MMDA MMDA may decrease the antihypertensive activities of Fenoldopam.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Fenoldopam.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Fenoldopam.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Fenoldopam.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Fenoldopam.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Fenoldopam.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Fenoldopam.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Fenoldopam.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Fenoldopam.
Solifenacin Solifenacin may decrease the antihypertensive activities of Fenoldopam.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Fenoldopam.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Fenoldopam.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Fenoldopam.
Amineptine Amineptine may decrease the antihypertensive activities of Fenoldopam.
Dronedarone Dronedarone may decrease the antihypertensive activities of Fenoldopam.
Flibanserin Flibanserin may decrease the antihypertensive activities of Fenoldopam.
Indacaterol Indacaterol may decrease the antihypertensive activities of Fenoldopam.
Amibegron Amibegron may decrease the antihypertensive activities of Fenoldopam.
Naluzotan Naluzotan may decrease the antihypertensive activities of Fenoldopam.
Cariprazine Cariprazine may decrease the antihypertensive activities of Fenoldopam.
Mianserin Mianserin may decrease the antihypertensive activities of Fenoldopam.
Nylidrin Nylidrin may decrease the antihypertensive activities of Fenoldopam.
Pizotifen Pizotifen may decrease the antihypertensive activities of Fenoldopam.
Solabegron Solabegron may decrease the antihypertensive activities of Fenoldopam.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Fenoldopam.
Vilazodone Vilazodone may decrease the antihypertensive activities of Fenoldopam.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Fenoldopam.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Fenoldopam.
Isometheptene Isometheptene may decrease the antihypertensive activities of Fenoldopam.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Fenoldopam.
Naphazoline Naphazoline may decrease the antihypertensive activities of Fenoldopam.
Saralasin Saralasin may decrease the antihypertensive activities of Fenoldopam.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Fenoldopam.
Cinitapride Cinitapride may decrease the antihypertensive activities of Fenoldopam.
Tyramine Tyramine may decrease the antihypertensive activities of Fenoldopam.
Adrafinil Adrafinil may decrease the antihypertensive activities of Fenoldopam.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Fenoldopam.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Fenoldopam.
Etilefrine Etilefrine may decrease the antihypertensive activities of Fenoldopam.

Target Protein

D(1B) dopamine receptor DRD5
D(1A) dopamine receptor DRD1
Alpha-1B adrenergic receptor ADRA1B
Alpha-1D adrenergic receptor ADRA1D
Alpha-1A adrenergic receptor ADRA1A
Alpha-2B adrenergic receptor ADRA2B
Alpha-2C adrenergic receptor ADRA2C
Alpha-2A adrenergic receptor ADRA2A

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 5 • International brands: 0
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Sekuens Gen/Protein (FASTA)

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