Excessive topical use may lead to marked redness, peeling, or discomfort. Oral ingestion of the drug may affect liver function causing hypertriglyceridemia. Other symptoms may include conjunctival irritation, hair loss, headache, edema, fatigue, dermatitis, nausea, and visual disturbances. Oral administration of this material to rats and rabbits at doses of 0.20 mg/kg/day (rabbits) and 0.25 mg/kg/day (rats) resulted in developmental toxicity. A no effect level of 0.05 mg/kg/day was established. Similar teratogenic effects have been reported for other retinoid compounds.
Tazarotene, commonly marketed as Tazorac®, Avage®, and Zorac®, is member of the acetylenic class of retinoids. It is a prodrug that is found in topical formulations used in the treatment of various conditons, such as psoriasis, acne, and sun damaged skin (photodamage).
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Mifepristone | The serum concentration of Tazarotene can be increased when it is combined with Mifepristone. |
| Estetrol | The therapeutic efficacy of Estetrol can be decreased when used in combination with Tazarotene. |
| Desogestrel | The therapeutic efficacy of Desogestrel can be decreased when used in combination with Tazarotene. |
| Megestrol acetate | The therapeutic efficacy of Megestrol acetate can be decreased when used in combination with Tazarotene. |
| Levonorgestrel | The therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Tazarotene. |
| Norethisterone | The therapeutic efficacy of Norethisterone can be decreased when used in combination with Tazarotene. |
| Ethynodiol diacetate | The therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Tazarotene. |
| Norgestimate | The therapeutic efficacy of Norgestimate can be decreased when used in combination with Tazarotene. |
| Drospirenone | The therapeutic efficacy of Drospirenone can be decreased when used in combination with Tazarotene. |
| Cyproterone acetate | The therapeutic efficacy of Cyproterone acetate can be decreased when used in combination with Tazarotene. |
| Gestodene | The therapeutic efficacy of Gestodene can be decreased when used in combination with Tazarotene. |
| Hydroxyprogesterone caproate | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Tazarotene. |
| Dienogest | The therapeutic efficacy of Dienogest can be decreased when used in combination with Tazarotene. |
| Norethynodrel | The therapeutic efficacy of Norethynodrel can be decreased when used in combination with Tazarotene. |
| Norgestrel | The therapeutic efficacy of Norgestrel can be decreased when used in combination with Tazarotene. |
| Gestrinone | The therapeutic efficacy of Gestrinone can be decreased when used in combination with Tazarotene. |
| Lynestrenol | The therapeutic efficacy of Lynestrenol can be decreased when used in combination with Tazarotene. |
| Chlormadinone | The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Tazarotene. |
| Norgestrienone | The therapeutic efficacy of Norgestrienone can be decreased when used in combination with Tazarotene. |
| Quingestanol | The therapeutic efficacy of Quingestanol can be decreased when used in combination with Tazarotene. |
| Demegestone | The therapeutic efficacy of Demegestone can be decreased when used in combination with Tazarotene. |
| Nomegestrol acetate | The therapeutic efficacy of Nomegestrol acetate can be decreased when used in combination with Tazarotene. |
| Vitamin A | The risk or severity of adverse effects can be increased when Vitamin A is combined with Tazarotene. |
| Secobarbital | The metabolism of Tazarotene can be increased when combined with Secobarbital. |
| Rifampin | The metabolism of Tazarotene can be increased when combined with Rifampicin. |
| Bexarotene | The metabolism of Tazarotene can be decreased when combined with Bexarotene. |
| Diltiazem | The metabolism of Tazarotene can be decreased when combined with Diltiazem. |
| Levothyroxine | The metabolism of Tazarotene can be decreased when combined with Levothyroxine. |
| Loratadine | The metabolism of Tazarotene can be decreased when combined with Loratadine. |
| Quinine | The metabolism of Tazarotene can be decreased when combined with Quinine. |
| Medroxyprogesterone acetate | The therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Tazarotene. |
| Nicardipine | The metabolism of Tazarotene can be decreased when combined with Nicardipine. |
| Efavirenz | The metabolism of Tazarotene can be decreased when combined with Efavirenz. |
| Tamoxifen | The metabolism of Tazarotene can be decreased when combined with Tamoxifen. |
| Ketoconazole | The metabolism of Tazarotene can be decreased when combined with Ketoconazole. |
| Irbesartan | The metabolism of Tazarotene can be decreased when combined with Irbesartan. |
| Oxybutynin | The metabolism of Tazarotene can be decreased when combined with Oxybutynin. |
| Fluvastatin | The metabolism of Tazarotene can be decreased when combined with Fluvastatin. |
| Pioglitazone | The metabolism of Tazarotene can be decreased when combined with Pioglitazone. |
| Saquinavir | The metabolism of Tazarotene can be decreased when combined with Saquinavir. |
| Genistein | The metabolism of Tazarotene can be decreased when combined with Genistein. |
| Topiroxostat | The metabolism of Tazarotene can be decreased when combined with Topiroxostat. |
| Abiraterone | The metabolism of Tazarotene can be decreased when combined with Abiraterone. |
| Eltrombopag | The metabolism of Tazarotene can be decreased when combined with Eltrombopag. |
| Teriflunomide | The metabolism of Tazarotene can be decreased when combined with Teriflunomide. |
| Enzalutamide | The metabolism of Tazarotene can be decreased when combined with Enzalutamide. |
| Trimethoprim | The metabolism of Tazarotene can be decreased when combined with Trimethoprim. |
| Ritonavir | The metabolism of Tazarotene can be decreased when combined with Ritonavir. |
| Fluticasone propionate | The metabolism of Tazarotene can be decreased when combined with Fluticasone propionate. |
| Clopidogrel | The metabolism of Tazarotene can be decreased when combined with Clopidogrel. |
| Candesartan cilexetil | The metabolism of Tazarotene can be decreased when combined with Candesartan cilexetil. |
| Salmeterol | The metabolism of Tazarotene can be decreased when combined with Salmeterol. |
| Felodipine | The metabolism of Tazarotene can be decreased when combined with Felodipine. |
| Gemfibrozil | The metabolism of Tazarotene can be decreased when combined with Gemfibrozil. |
| Fluticasone | The metabolism of Tazarotene can be decreased when combined with Fluticasone. |
| Mometasone furoate | The metabolism of Tazarotene can be decreased when combined with Mometasone furoate. |
| Pyrimethamine | The metabolism of Tazarotene can be decreased when combined with Pyrimethamine. |
| Ticlopidine | The metabolism of Tazarotene can be decreased when combined with Ticlopidine. |
| Cimetidine | The metabolism of Tazarotene can be decreased when combined with Cimetidine. |
| Rofecoxib | The metabolism of Tazarotene can be decreased when combined with Rofecoxib. |
| Quinidine | The metabolism of Tazarotene can be decreased when combined with Quinidine. |
| Ketoprofen | The metabolism of Tazarotene can be decreased when combined with Ketoprofen. |
| Fenofibrate | The metabolism of Tazarotene can be decreased when combined with Fenofibrate. |
| Atazanavir | The metabolism of Tazarotene can be decreased when combined with Atazanavir. |
| Tegaserod | The metabolism of Tazarotene can be decreased when combined with Tegaserod. |
| Cabozantinib | The metabolism of Tazarotene can be decreased when combined with Cabozantinib. |
| Diethylstilbestrol | The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Tazarotene. |
| Terfenadine | The metabolism of Tazarotene can be decreased when combined with Terfenadine. |
| Cerivastatin | The metabolism of Tazarotene can be decreased when combined with Cerivastatin. |
| Raloxifene | The metabolism of Tazarotene can be decreased when combined with Raloxifene. |
| Simvastatin | The metabolism of Tazarotene can be decreased when combined with Simvastatin. |
| Nilutamide | The metabolism of Tazarotene can be decreased when combined with Nilutamide. |
| Metronidazole | The metabolism of Tazarotene can be decreased when combined with Metronidazole. |
| Ethinylestradiol | The therapeutic efficacy of Ethinylestradiol can be decreased when used in combination with Tazarotene. |
| Bezafibrate | The metabolism of Tazarotene can be decreased when combined with Bezafibrate. |
| Deferasirox | The metabolism of Tazarotene can be decreased when combined with Deferasirox. |
| Quercetin | The metabolism of Tazarotene can be decreased when combined with Quercetin. |
| Licofelone | The metabolism of Tazarotene can be decreased when combined with Licofelone. |
| Nilvadipine | The metabolism of Tazarotene can be decreased when combined with Nilvadipine. |
| Sulfaphenazole | The metabolism of Tazarotene can be decreased when combined with Sulfaphenazole. |
| Vemurafenib | The metabolism of Tazarotene can be decreased when combined with Vemurafenib. |
| Lumacaftor | The metabolism of Tazarotene can be decreased when combined with Lumacaftor. |
| Isavuconazole | The metabolism of Tazarotene can be decreased when combined with Isavuconazole. |
| Alpelisib | The metabolism of Tazarotene can be decreased when combined with Alpelisib. |
| Letermovir | The metabolism of Tazarotene can be decreased when combined with Letermovir. |
| Triclabendazole | The metabolism of Tazarotene can be decreased when combined with Triclabendazole. |
| Candesartan | The metabolism of Tazarotene can be decreased when combined with Candesartan. |
| Favipiravir | The metabolism of Tazarotene can be decreased when combined with Favipiravir. |
| Methylene blue | The metabolism of Tazarotene can be decreased when combined with Methylene blue. |
| Mometasone | The metabolism of Tazarotene can be decreased when combined with Mometasone. |
| Pralsetinib | The metabolism of Tazarotene can be decreased when combined with Pralsetinib. |
| Miconazole | The metabolism of Tazarotene can be decreased when combined with Miconazole. |
| Rilpivirine | The metabolism of Tazarotene can be decreased when combined with Rilpivirine. |
| Rifabutin | The metabolism of Tazarotene can be increased when combined with Rifabutin. |
| Cyclophosphamide | The metabolism of Tazarotene can be increased when combined with Cyclophosphamide. |
| Hydrocortisone | The metabolism of Tazarotene can be increased when combined with Hydrocortisone. |
| Probenecid | The metabolism of Tazarotene can be increased when combined with Probenecid. |
| Ifosfamide | The metabolism of Tazarotene can be increased when combined with Ifosfamide. |
| Rifapentine | The metabolism of Tazarotene can be increased when combined with Rifapentine. |
| Dexamethasone | The metabolism of Tazarotene can be increased when combined with Dexamethasone. |