Haloprogin

DB00793

small molecule approved withdrawn

Deskripsi

Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. Haloprogin is no longer available in the United States and has been discontinued.

Struktur Molekul 2D

Berat 361.391
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

14 Data
Dicoumarol The therapeutic efficacy of Dicoumarol can be increased when used in combination with Haloprogin.
Phenindione The therapeutic efficacy of Phenindione can be increased when used in combination with Haloprogin.
Warfarin The therapeutic efficacy of Warfarin can be increased when used in combination with Haloprogin.
Phenprocoumon The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Haloprogin.
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Haloprogin.
4-hydroxycoumarin The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Haloprogin.
Coumarin The therapeutic efficacy of Coumarin can be increased when used in combination with Haloprogin.
(R)-warfarin The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Haloprogin.
Ethyl biscoumacetate The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Haloprogin.
Fluindione The therapeutic efficacy of Fluindione can be increased when used in combination with Haloprogin.
Clorindione The therapeutic efficacy of Clorindione can be increased when used in combination with Haloprogin.
Diphenadione The therapeutic efficacy of Diphenadione can be increased when used in combination with Haloprogin.
Tioclomarol The therapeutic efficacy of Tioclomarol can be increased when used in combination with Haloprogin.
(S)-Warfarin The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Haloprogin.

Referensi & Sumber

Synthesis reference: U.S. Patent 3,322,813.
Artikel (PubMed)
  • PMID: 5422306
    Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50.
  • PMID: 4608935
    Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Aloprogen — Westwood
  • Halotex — Westwood
  • Mycanden — Schering
  • Mycilan — Schering-Plough
  • Polik — Meiji

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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