Peringatan Keamanan

Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.

Mefenamic acid

DB00784

small molecule approved

Deskripsi

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Struktur Molekul 2D

Berat 241.2851
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2 hours
Volume Distribusi * 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
Klirens (Clearance) * Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]

Absorpsi

Mefenamic acid is rapidly absorbed after oral administration.

Metabolisme

Mefenamic acid undergoes metabolism by CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur. The activity of these metabolites has not been studied. Mefenamic acid is also glucuronidated directly.

Rute Eliminasi

The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.

Interaksi Makanan

2 Data
  • 1. Avoid alcohol.
  • 2. Take with food.

Interaksi Obat

1702 Data
Peginterferon alfa-2b The serum concentration of Mefenamic acid can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Mefenamic acid can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Mefenamic acid can be decreased when it is combined with Teriflunomide.
Amlodipine The metabolism of Mefenamic acid can be decreased when combined with Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Mefenamic acid.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Mefenamic acid.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Mefenamic acid.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Mefenamic acid.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Mefenamic acid.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Mefenamic acid.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Mefenamic acid.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Mefenamic acid.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Mefenamic acid.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Mefenamic acid.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Mefenamic acid.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Mefenamic acid.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Mefenamic acid.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Mefenamic acid.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Mefenamic acid.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Mefenamic acid.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Mefenamic acid.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Mefenamic acid.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Mefenamic acid.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Mefenamic acid.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Mefenamic acid.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Mefenamic acid.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Mefenamic acid.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Mefenamic acid.
Alfentanil The risk or severity of hypertension can be increased when Mefenamic acid is combined with Alfentanil.
Minaprine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Minaprine.
Orciprenaline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Orciprenaline.
Phenmetrazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Phenmetrazine.
Pseudoephedrine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Pseudoephedrine.
Benzphetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Benzphetamine.
Ritodrine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Ritodrine.
Flupentixol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Flupentixol.
Remifentanil The risk or severity of hypertension can be increased when Mefenamic acid is combined with Remifentanil.
Bitolterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Bitolterol.
Oxymetazoline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Oxymetazoline.
Diethylpropion The risk or severity of hypertension can be increased when Mefenamic acid is combined with Diethylpropion.
Naratriptan The risk or severity of hypertension can be increased when Mefenamic acid is combined with Naratriptan.
Ergoloid mesylate The risk or severity of hypertension can be increased when Mefenamic acid is combined with Ergoloid mesylate.
Isoprenaline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Isoprenaline.
Arbutamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Arbutamine.
Dutasteride The risk or severity of hypertension can be increased when Mefenamic acid is combined with Dutasteride.
Pergolide The risk or severity of hypertension can be increased when Mefenamic acid is combined with Pergolide.
Desflurane The risk or severity of hypertension can be increased when Mefenamic acid is combined with Desflurane.
Bromocriptine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Bromocriptine.
Finasteride The risk or severity of hypertension can be increased when Mefenamic acid is combined with Finasteride.
Aripiprazole The risk or severity of hypertension can be increased when Mefenamic acid is combined with Aripiprazole.
Isocarboxazid The risk or severity of hypertension can be increased when Mefenamic acid is combined with Isocarboxazid.
Ergometrine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Ergometrine.
Lisdexamfetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Lisdexamfetamine.
Fenoterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Fenoterol.
Pirbuterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Pirbuterol.
Ephedra sinica root The risk or severity of hypertension can be increased when Mefenamic acid is combined with Ephedra sinica root.
Ephedrine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Ephedrine.
Mephentermine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Mephentermine.
Procaterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Procaterol.
Yohimbine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Yohimbine.
Methotrimeprazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Methotrimeprazine.
Clenbuterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Clenbuterol.
Bambuterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Bambuterol.
MMDA The risk or severity of hypertension can be increased when Mefenamic acid is combined with MMDA.
Midomafetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Midomafetamine.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with 2,5-Dimethoxy-4-ethylamphetamine.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with 4-Methoxyamphetamine.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with 4-Bromo-2,5-dimethoxyamphetamine.
Tenamfetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Tenamfetamine.
Chlorphentermine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Chlorphentermine.
Dextroamphetamine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Dextroamphetamine.
Phendimetrazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Phendimetrazine.
Solifenacin The risk or severity of hypertension can be increased when Mefenamic acid is combined with Solifenacin.
Periciazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Periciazine.
Acepromazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Acepromazine.
Thioproperazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Thioproperazine.
Zuclopenthixol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Zuclopenthixol.
Epicaptopril The risk or severity of hypertension can be increased when Mefenamic acid is combined with Epicaptopril.
Clorgiline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Clorgiline.
1-benzylimidazole The risk or severity of hypertension can be increased when Mefenamic acid is combined with 1-benzylimidazole.
Nialamide The risk or severity of hypertension can be increased when Mefenamic acid is combined with Nialamide.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Mefenamic acid is combined with Lysergic acid diethylamide.
Dronedarone The risk or severity of hypertension can be increased when Mefenamic acid is combined with Dronedarone.
Flibanserin The risk or severity of hypertension can be increased when Mefenamic acid is combined with Flibanserin.
Iloperidone The risk or severity of hypertension can be increased when Mefenamic acid is combined with Iloperidone.
Indacaterol The risk or severity of hypertension can be increased when Mefenamic acid is combined with Indacaterol.
Rotigotine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Rotigotine.
Amibegron The risk or severity of hypertension can be increased when Mefenamic acid is combined with Amibegron.
Naluzotan The risk or severity of hypertension can be increased when Mefenamic acid is combined with Naluzotan.
Cariprazine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Cariprazine.
Pizotifen The risk or severity of hypertension can be increased when Mefenamic acid is combined with Pizotifen.
Solabegron The risk or severity of hypertension can be increased when Mefenamic acid is combined with Solabegron.
Esmirtazapine The risk or severity of hypertension can be increased when Mefenamic acid is combined with Esmirtazapine.
Vilazodone The risk or severity of hypertension can be increased when Mefenamic acid is combined with Vilazodone.
Nitrous oxide The risk or severity of hypertension can be increased when Mefenamic acid is combined with Nitrous oxide.
Xylometazoline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Xylometazoline.
Dexmethylphenidate The risk or severity of hypertension can be increased when Mefenamic acid is combined with Dexmethylphenidate.
Isometheptene The risk or severity of hypertension can be increased when Mefenamic acid is combined with Isometheptene.
Levonordefrin The risk or severity of hypertension can be increased when Mefenamic acid is combined with Levonordefrin.
Naphazoline The risk or severity of hypertension can be increased when Mefenamic acid is combined with Naphazoline.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 23 • International brands: 10
Produk
  • Dom-mefenamic Acid
    Capsule • 250 mg • Oral • Canada • Generic • Approved
  • Mefenamic
    Capsule • 250 mg • Oral • Canada • Approved
  • Mefenamic acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Mefenamic Acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Mefenamic Acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Mefenamic Acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Mefenamic Acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
  • Mefenamic Acid
    Capsule • 250 mg/1 • Oral • US • Generic • Approved
Menampilkan 8 dari 23 produk.
International Brands
  • Coslan — Parke Davis
  • Lysalgo — SIT
  • Mefacit — SecFarm
  • Parkemed — Pfizer
  • Ponalar — Coronet Crown
  • Ponstan Forte — Pfizer
  • Ponstyl — Pfizer
  • Ponstyl Fort — Pfizer
  • Pontal — Daiichi Sankyo
  • Tanston — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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