Peringatan Keamanan

Phenelzine, as must of the monoamine oxidase inhibitors, can cause transient, mild and asymptomatic aminotransferase elevations. It has also been reported to be associated with cases of liver injury after 1-3 months of treatment.A31929

Phenelzine

DB00780

small molecule approved

Deskripsi

Phenelzine, with the formula ?-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder.A15753 It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil.

Struktur Molekul 2D

Berat 136.1943
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) After administration phenelzine presents a very short half-life of 11.6 hours in humans.[L1365]
Volume Distribusi The volume of distribution of phenelzine is hard to determine as drugs from this kind penetrate the CNS very well into the tissue where their activity is desired.[T113]
Klirens (Clearance) -

Absorpsi

Phenelzine is rapidly absorbed from the gastrointestinal tract. The decay of the drug action is not dependent on the pharmacokinetic parameters but on the rate of protein synthesis which restores the functional levels of monoamine oxidase.L1365 The mean Cmax is 19.8 ng/ml and it occurs after 43 minutes of dose administration.FDA label

Metabolisme

For the metabolic studies, it is assumed that phenelzine is acetylated. Some of the metabolites of phenelzine are phenylacetic acid, 2-phenylethylamine and 4-hydroxyphenylacetic acid as major metabolites and N-acetyl-phenelzine as a minor metabolite.A31925

Rute Eliminasi

The elimination of the administered dose is mainly composed of the phenelzine metabolites, phenylacetic acid and parahydroxyphenylacetic acid that constitute 79% of the dose found in the urine in the first 96 hours.A31928

Interaksi Makanan

4 Data
  • 1. Avoid alcohol.
  • 2. Avoid St. John's Wort. Administering phenelzine with St. John's Wort may increase the risk of serotonin syndrome.
  • 3. Avoid tyramine-containing foods and supplements. Tyramine-containing foods and beverages can cause a sudden elevation in blood pressure or a hypertensive crisis. Foods that contain tyramine include aged cheese, ripe bananas, red wine, some alcoholic beverages (beer), cured food, pickled food, and fava beans.
  • 4. Limit caffeine intake. Excess caffeine intake can also cause a hypertensive crisis.

Interaksi Obat

1756 Data
Risperidone Phenelzine may increase the hypotensive activities of Risperidone.
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Phenelzine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Phenelzine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Magnesium sulfate The therapeutic efficacy of Phenelzine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Phenelzine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Orphenadrine Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Phenelzine.
Pramipexole Phenelzine may increase the sedative activities of Pramipexole.
Ropinirole Phenelzine may increase the sedative activities of Ropinirole.
Rotigotine Phenelzine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Phenelzine.
Sodium oxybate Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Thalidomide Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Phenelzine.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Phenelzine.
Succinylcholine Phenelzine may increase the neuromuscular blocking activities of Succinylcholine.
Phenmetrazine The risk or severity of hypertension can be increased when Phenelzine is combined with Phenmetrazine.
Ephedrine The risk or severity of hypertension can be increased when Phenelzine is combined with Ephedrine.
Epicaptopril The risk or severity of hypertension can be increased when Phenelzine is combined with Epicaptopril.
Taxifolin The risk or severity of hypertension can be increased when Phenelzine is combined with Taxifolin.
1-benzylimidazole The risk or severity of hypertension can be increased when Phenelzine is combined with 1-benzylimidazole.
Amibegron The risk or severity of hypertension can be increased when Phenelzine is combined with Amibegron.
Solabegron The risk or severity of hypertension can be increased when Phenelzine is combined with Solabegron.
Saralasin The risk or severity of hypertension can be increased when Phenelzine is combined with Saralasin.
Tyramine The risk or severity of hypertension can be increased when Phenelzine is combined with Tyramine.
Adrafinil The risk or severity of hypertension can be increased when Phenelzine is combined with Adrafinil.
Etilefrine The risk or severity of hypertension can be increased when Phenelzine is combined with Etilefrine.
Synephrine The risk or severity of hypertension can be increased when Phenelzine is combined with Synephrine.
Amitraz The risk or severity of hypertension can be increased when Phenelzine is combined with Amitraz.
Atipamezole The risk or severity of hypertension can be increased when Phenelzine is combined with Atipamezole.
Ractopamine The risk or severity of hypertension can be increased when Phenelzine is combined with Ractopamine.
Tulobuterol The risk or severity of hypertension can be increased when Phenelzine is combined with Tulobuterol.
Dopexamine The risk or severity of hypertension can be increased when Phenelzine is combined with Dopexamine.
Idazoxan The risk or severity of hypertension can be increased when Phenelzine is combined with Idazoxan.
Ebselen The risk or severity of hypertension can be increased when Phenelzine is combined with Ebselen.
Higenamine The risk or severity of hypertension can be increased when Phenelzine is combined with Higenamine.
Reproterol The risk or severity of hypertension can be increased when Phenelzine is combined with Reproterol.
Theodrenaline The risk or severity of hypertension can be increased when Phenelzine is combined with Theodrenaline.
Tramazoline The risk or severity of hypertension can be increased when Phenelzine is combined with Tramazoline.
Octopamine The risk or severity of hypertension can be increased when Phenelzine is combined with Octopamine.
Fenozolone The risk or severity of hypertension can be increased when Phenelzine is combined with Fenozolone.
Norfenefrine The risk or severity of hypertension can be increased when Phenelzine is combined with Norfenefrine.
Oxyfedrine The risk or severity of hypertension can be increased when Phenelzine is combined with Oxyfedrine.
Xenon The risk or severity of adverse effects can be increased when Xenon is combined with Phenelzine.
Rimiterol The risk or severity of hypertension can be increased when Phenelzine is combined with Rimiterol.
Tretoquinol The risk or severity of hypertension can be increased when Phenelzine is combined with Tretoquinol.
Prenalterol The risk or severity of hypertension can be increased when Phenelzine is combined with Prenalterol.
Xamoterol The risk or severity of hypertension can be increased when Phenelzine is combined with Xamoterol.
Mefenorex The risk or severity of hypertension can be increased when Phenelzine is combined with Mefenorex.
Deoxyepinephrine The risk or severity of hypertension can be increased when Phenelzine is combined with Deoxyepinephrine.
Quinoline Yellow WS The risk or severity of hypertension can be increased when Phenelzine is combined with Quinoline Yellow WS.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Phenelzine.
Indacaterol The risk or severity of hypertension can be increased when Phenelzine is combined with Indacaterol.
Nylidrin The risk or severity of hypertension can be increased when Phenelzine is combined with Nylidrin.
Terguride The risk or severity of hypertension can be increased when Phenelzine is combined with Terguride.
Selpercatinib The risk or severity of hypertension can be increased when Phenelzine is combined with Selpercatinib.
Naxitamab The risk or severity of hypertension can be increased when Phenelzine is combined with Naxitamab.
Olodaterol The risk or severity of hypertension can be increased when Phenelzine is combined with Olodaterol.
Dihydroergocornine The risk or severity of hypertension can be increased when Phenelzine is combined with Dihydroergocornine.
Siponimod The risk or severity of hypertension can be increased when Phenelzine is combined with Siponimod.
Dihydroergocristine The risk or severity of hypertension can be increased when Phenelzine is combined with Dihydroergocristine.
Dihydroergocryptine The risk or severity of hypertension can be increased when Phenelzine is combined with Dihydroergocryptine.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Phenelzine.
Salmeterol The risk or severity of hypertension can be increased when Phenelzine is combined with Salmeterol.
Dutasteride The risk or severity of hypertension can be increased when Phenelzine is combined with Dutasteride.
Propafenone The risk or severity of hypertension can be increased when Phenelzine is combined with Propafenone.
Finasteride The risk or severity of hypertension can be increased when Phenelzine is combined with Finasteride.
Arformoterol The risk or severity of hypertension can be increased when Phenelzine is combined with Arformoterol.
Dronedarone The risk or severity of hypertension can be increased when Phenelzine is combined with Dronedarone.
Mirabegron The risk or severity of hypertension can be increased when Phenelzine is combined with Mirabegron.
Anisodamine The risk or severity of hypertension can be increased when Phenelzine is combined with Anisodamine.
Colchicine The metabolism of Colchicine can be decreased when combined with Phenelzine.
Fentanyl The risk or severity of serotonin syndrome can be increased when Phenelzine is combined with Fentanyl.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Phenelzine.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Phenelzine.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Phenelzine.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Phenelzine.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Phenelzine.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Phenelzine.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Phenelzine.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Phenelzine.
Apraclonidine Phenelzine may increase the alpha-adrenergic activities of Apraclonidine.
Atomoxetine The risk or severity of adverse effects can be increased when Phenelzine is combined with Atomoxetine.
Betahistine The metabolism of Betahistine can be decreased when combined with Phenelzine.
Bezafibrate Phenelzine may increase the hepatotoxic activities of Bezafibrate.
Buprenorphine Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Bupropion The risk or severity of adverse effects can be increased when Phenelzine is combined with Bupropion.
Buspirone The risk or severity of hypertension can be increased when Phenelzine is combined with Buspirone.
Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Phenelzine.
Cyclobenzaprine Cyclobenzaprine may increase the serotonergic activities of Phenelzine.
Cyproheptadine Phenelzine may increase the anticholinergic activities of Cyproheptadine.

Target Protein

Amine oxidase [flavin-containing] A MAOA
Amine oxidase [flavin-containing] B MAOB
Amine oxidase [copper-containing] 3 AOC3
4-aminobutyrate aminotransferase, mitochondrial ABAT
Alanine aminotransferase 1 GPT
Alanine aminotransferase 2 GPT2
Glutamic acid decarboxylase GAD65

Referensi & Sumber

Artikel (PubMed)
  • PMID: 14574774
    Nolen WA: Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression. Ned Tijdschr Geneeskd. 2003 Oct 4;147(40):1940-3.
  • PMID: 15462176
    Sowa BN, Holt A, Todd KG, Baker GB: Monoamine oxidase inhibitors, their structural analogues, and neuroprotection. Indian J Exp Biol. 2004 Sep;42(9):851-7.
  • PMID: 19203467
    Todd KG, Baker GB: Neurochemical effects of the monoamine oxidase inhibitor phenelzine on brain GABA and alanine: A comparison with vigabatrin. J Pharm Pharm Sci. 2008 May 16;11(2):14s-21s.
  • PMID: 21103169
    Singh T, Williams K: Atypical depression. Psychiatry (Edgmont). 2006 Apr;3(4):33-9.
  • PMID: 3678293
    Winokur G, Black DW, Nasrallah A: Neurotic depression: a diagnosis based on preexisting characteristics. Eur Arch Psychiatry Neurol Sci. 1987;236(6):343-8.
  • PMID: 6456291
    Benjaminsen S: Primary non-endogenous depression and features attributed to reactive depression. J Affect Disord. 1981 Sep;3(3):245-59.
  • PMID: 1362653
    Baker GB, Coutts RT, McKenna KF, Sherry-McKenna RL: Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review. J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
  • PMID: 4066998
    Robinson DS, Cooper TB, Jindal SP, Corcella J, Lutz T: Metabolism and pharmacokinetics of phenelzine: lack of evidence for acetylation pathway in humans. J Clin Psychopharmacol. 1985 Dec;5(6):333-7.
Menampilkan 8 dari 9 artikel.
Textbook
  • Preskon S., Feighner J., Stanga C. and Ross R. (2004). Antidepressants: Past, Present and Future. Springer-Verlag.
  • Owens D. (2010). Companion to psychiatric studies (8th ed.). Elsevier.

Contoh Produk & Brand

Produk: 8 • International brands: 2
Produk
  • Greenstone Brand Phenelzine Sulfate
    Tablet • 15 mg/1 • Oral • US • Generic • Approved
  • Nardil
    Tablet, film coated • 15 mg/1 • Oral • US • Approved
  • Nardil
    Tablet • 15 mg • Oral • Canada • Approved
  • Nardil Phenelzine Sulfate
    Tablet, film coated • 15 mg/1 • Oral • US • Approved
  • Phenelzine Sulfate
    Tablet • 15 mg/1 • Oral • US • Generic • Approved
  • Phenelzine Sulfate
    Tablet • 15 mg/1 • Oral • US • Generic • Approved
  • Phenelzine Sulfate
    Tablet, film coated • 15 mg/1 • Oral • US • Generic • Approved
  • Phenelzine Sulfate
    Tablet • 15 mg/1 • Oral • US • Generic • Approved
International Brands
  • Margyl — DIM
  • Nardelzine — Pfizer

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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