Peringatan Keamanan

Although rare, serious adverse events may be seen with propiomazine. Such events include convulsions (seizures), difficult or unusually fast breathing, fast or irregular heartbeat or pulse, fever (high), high or low blood pressure, loss of bladder control, muscle stiffness (severe), unusual increase in sweating, unusually pale skin, and unusual tiredness or weakness.

Propiomazine

DB00777

small molecule approved

Deskripsi

Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.

Struktur Molekul 2D

Berat 340.482
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Unknown, but most likely hepatic as with other phenothiazines.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1337 Data
Valsartan Propiomazine may decrease the antihypertensive activities of Valsartan.
Remikiren Propiomazine may decrease the antihypertensive activities of Remikiren.
Torasemide Propiomazine may decrease the antihypertensive activities of Torasemide.
Guanadrel Propiomazine may decrease the antihypertensive activities of Guanadrel.
Olmesartan Propiomazine may decrease the antihypertensive activities of Olmesartan.
Nitroprusside Propiomazine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Propiomazine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Propiomazine may decrease the antihypertensive activities of Treprostinil.
Fosinopril Propiomazine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Propiomazine may decrease the antihypertensive activities of Trandolapril.
Benazepril Propiomazine may decrease the antihypertensive activities of Benazepril.
Bosentan Propiomazine may decrease the antihypertensive activities of Bosentan.
Enalapril Propiomazine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Propiomazine may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Propiomazine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Propiomazine may decrease the antihypertensive activities of Mecamylamine.
Losartan Propiomazine may decrease the antihypertensive activities of Losartan.
Moexipril Propiomazine may decrease the antihypertensive activities of Moexipril.
Eplerenone Propiomazine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Propiomazine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Propiomazine may decrease the antihypertensive activities of Nitroglycerin.
Cryptenamine Propiomazine may decrease the antihypertensive activities of Cryptenamine.
Candesartan cilexetil Propiomazine may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Propiomazine may decrease the antihypertensive activities of Eprosartan.
Quinapril Propiomazine may decrease the antihypertensive activities of Quinapril.
Telmisartan Propiomazine may decrease the antihypertensive activities of Telmisartan.
Irbesartan Propiomazine may decrease the antihypertensive activities of Irbesartan.
Deserpidine Propiomazine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Propiomazine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Propiomazine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Propiomazine may decrease the antihypertensive activities of Diazoxide.
Bretylium Propiomazine may decrease the antihypertensive activities of Bretylium.
Guanethidine Propiomazine may decrease the antihypertensive activities of Guanethidine.
Captopril Propiomazine may decrease the antihypertensive activities of Captopril.
Epoprostenol Propiomazine may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Propiomazine may decrease the antihypertensive activities of Hydralazine.
Cilazapril Propiomazine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Propiomazine may decrease the antihypertensive activities of Saprisartan.
Spirapril Propiomazine may decrease the antihypertensive activities of Spirapril.
Tienilic acid Propiomazine may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Propiomazine may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Propiomazine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Propiomazine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Propiomazine may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Propiomazine may decrease the antihypertensive activities of Pinacidil.
Temocapril Propiomazine may decrease the antihypertensive activities of Temocapril.
Riociguat Propiomazine may decrease the antihypertensive activities of Riociguat.
Macitentan Propiomazine may decrease the antihypertensive activities of Macitentan.
Aliskiren Propiomazine may decrease the antihypertensive activities of Aliskiren.
Nicorandil Propiomazine may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Propiomazine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Propiomazine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Propiomazine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Propiomazine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Propiomazine may decrease the antihypertensive activities of Imidapril.
BQ-123 Propiomazine may decrease the antihypertensive activities of BQ-123.
Cicletanine Propiomazine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Propiomazine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Propiomazine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Propiomazine may decrease the antihypertensive activities of Guanoxan.
Delapril Propiomazine may decrease the antihypertensive activities of Delapril.
Vincamine Propiomazine may decrease the antihypertensive activities of Vincamine.
Linsidomine Propiomazine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Propiomazine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Propiomazine may decrease the antihypertensive activities of Tolonidine.
Endralazine Propiomazine may decrease the antihypertensive activities of Endralazine.
Cadralazine Propiomazine may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Propiomazine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Propiomazine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Propiomazine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Propiomazine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Propiomazine may decrease the antihypertensive activities of Muzolimine.
Xipamide Propiomazine may decrease the antihypertensive activities of Xipamide.
Candesartan Propiomazine may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Propiomazine may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Propiomazine may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Propiomazine may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Propiomazine may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Propiomazine may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Propiomazine may decrease the antihypertensive activities of Quinaprilat.
Furosemide Propiomazine may decrease the antihypertensive activities of Furosemide.
Ramipril Propiomazine may decrease the antihypertensive activities of Ramipril.
Perindopril Propiomazine may decrease the antihypertensive activities of Perindopril.
Levamlodipine Propiomazine may decrease the antihypertensive activities of Levamlodipine.
Buthiazide Propiomazine may decrease the antihypertensive activities of Buthiazide.
Azilsartan medoxomil Propiomazine may decrease the antihypertensive activities of Azilsartan medoxomil.
Buprenorphine Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Hydrocodone Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Magnesium sulfate The therapeutic efficacy of Propiomazine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Propiomazine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Mirtazapine Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Propiomazine.
Orphenadrine Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Propiomazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.

Target Protein

Histamine H1 receptor HRH1
Muscarinic acetylcholine receptor CHRM1
Alpha-1A adrenergic receptor ADRA1A
D(2) dopamine receptor DRD2
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 6
International Brands
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  • Serentin

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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