Peringatan Keamanan

Overdoses lead to diuresis, lethargy progressing to coma, with minimal cardiorespiratory depression and with or without significant serum electrolyte changes or dehydration.

Hydroflumethiazide

DB00774

small molecule approved investigational withdrawn

Deskripsi

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)

Struktur Molekul 2D

Berat 331.292
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) It appears to have a biphasic biological half-life with an estimated alpha-phase of about 2 hours and an estimated beta-phase of about 17 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract

Metabolisme

Essentially unchanged

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Increase consumption of potassium-rich foods. This medication may cause a loss of potassium.

Interaksi Obat

1647 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Hydroflumethiazide is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Hydroflumethiazide is combined with Levodopa.
Risperidone Hydroflumethiazide may increase the hypotensive activities of Risperidone.
Alfuzosin Alfuzosin may increase the hypotensive activities of Hydroflumethiazide.
Amifostine Hydroflumethiazide may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Hydroflumethiazide.
Forasartan Hydroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Forasartan.
Tasosartan Hydroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Tasosartan.
Saralasin Hydroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Saralasin.
Fimasartan Hydroflumethiazide may increase the hypotensive and Electrolyte Disturbance activities of Fimasartan.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Hydroflumethiazide.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Hydroflumethiazide.
Obinutuzumab Hydroflumethiazide may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Hydroflumethiazide.
Rituximab Hydroflumethiazide may increase the hypotensive activities of Rituximab.
Phentermine Phentermine may decrease the antihypertensive activities of Hydroflumethiazide.
Midodrine Midodrine may decrease the antihypertensive activities of Hydroflumethiazide.
Eletriptan Eletriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Methysergide Methysergide may decrease the antihypertensive activities of Hydroflumethiazide.
Cabergoline Cabergoline may decrease the antihypertensive activities of Hydroflumethiazide.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Hydroflumethiazide.
Protriptyline Protriptyline may decrease the antihypertensive activities of Hydroflumethiazide.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Hydroflumethiazide.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Hydroflumethiazide.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Hydroflumethiazide.
Droperidol Droperidol may decrease the antihypertensive activities of Hydroflumethiazide.
Doxapram Doxapram may decrease the antihypertensive activities of Hydroflumethiazide.
Lisuride Lisuride may decrease the antihypertensive activities of Hydroflumethiazide.
Metaraminol Metaraminol may decrease the antihypertensive activities of Hydroflumethiazide.
Ergotamine Ergotamine may decrease the antihypertensive activities of Hydroflumethiazide.
Nicergoline Nicergoline may decrease the antihypertensive activities of Hydroflumethiazide.
Methoxamine Methoxamine may decrease the antihypertensive activities of Hydroflumethiazide.
Trimipramine Trimipramine may decrease the antihypertensive activities of Hydroflumethiazide.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Hydroflumethiazide.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Hydroflumethiazide.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Hydroflumethiazide.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Hydroflumethiazide.
Naratriptan Naratriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Hydroflumethiazide.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Hydroflumethiazide.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Hydroflumethiazide.
Dutasteride Dutasteride may decrease the antihypertensive activities of Hydroflumethiazide.
Propafenone Propafenone may decrease the antihypertensive activities of Hydroflumethiazide.
Pergolide Pergolide may decrease the antihypertensive activities of Hydroflumethiazide.
Finasteride Finasteride may decrease the antihypertensive activities of Hydroflumethiazide.
Ergometrine Ergometrine may decrease the antihypertensive activities of Hydroflumethiazide.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Mephentermine Mephentermine may decrease the antihypertensive activities of Hydroflumethiazide.
Yohimbine Yohimbine may decrease the antihypertensive activities of Hydroflumethiazide.
MMDA MMDA may decrease the antihypertensive activities of Hydroflumethiazide.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Hydroflumethiazide.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Hydroflumethiazide.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Hydroflumethiazide.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Hydroflumethiazide.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Hydroflumethiazide.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Hydroflumethiazide.
Periciazine Periciazine may decrease the antihypertensive activities of Hydroflumethiazide.
Acepromazine Acepromazine may decrease the antihypertensive activities of Hydroflumethiazide.
Thioproperazine Thioproperazine may decrease the antihypertensive activities of Hydroflumethiazide.
Zuclopenthixol Zuclopenthixol may decrease the antihypertensive activities of Hydroflumethiazide.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Hydroflumethiazide.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Hydroflumethiazide.
Lysergic acid diethylamide Lysergic acid diethylamide may decrease the antihypertensive activities of Hydroflumethiazide.
Amineptine Amineptine may decrease the antihypertensive activities of Hydroflumethiazide.
Dronedarone Dronedarone may decrease the antihypertensive activities of Hydroflumethiazide.
Flibanserin Flibanserin may decrease the antihypertensive activities of Hydroflumethiazide.
Iloperidone Iloperidone may decrease the antihypertensive activities of Hydroflumethiazide.
Amibegron Amibegron may decrease the antihypertensive activities of Hydroflumethiazide.
Naluzotan Naluzotan may decrease the antihypertensive activities of Hydroflumethiazide.
Cariprazine Cariprazine may decrease the antihypertensive activities of Hydroflumethiazide.
Mianserin Mianserin may decrease the antihypertensive activities of Hydroflumethiazide.
Nylidrin Nylidrin may decrease the antihypertensive activities of Hydroflumethiazide.
Solabegron Solabegron may decrease the antihypertensive activities of Hydroflumethiazide.
Asenapine Asenapine may decrease the antihypertensive activities of Hydroflumethiazide.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Hydroflumethiazide.
Vilazodone Vilazodone may decrease the antihypertensive activities of Hydroflumethiazide.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Hydroflumethiazide.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Hydroflumethiazide.
Isometheptene Isometheptene may decrease the antihypertensive activities of Hydroflumethiazide.
Naphazoline Naphazoline may decrease the antihypertensive activities of Hydroflumethiazide.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Hydroflumethiazide.
Cinitapride Cinitapride may decrease the antihypertensive activities of Hydroflumethiazide.
Lurasidone Lurasidone may decrease the antihypertensive activities of Hydroflumethiazide.
Tyramine Tyramine may decrease the antihypertensive activities of Hydroflumethiazide.
Adrafinil Adrafinil may decrease the antihypertensive activities of Hydroflumethiazide.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Hydroflumethiazide.
Etilefrine Etilefrine may decrease the antihypertensive activities of Hydroflumethiazide.
Butriptyline Butriptyline may decrease the antihypertensive activities of Hydroflumethiazide.
Cannabidiol Cannabidiol may decrease the antihypertensive activities of Hydroflumethiazide.
Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Hydroflumethiazide.
Cirazoline Cirazoline may decrease the antihypertensive activities of Hydroflumethiazide.
Synephrine Synephrine may decrease the antihypertensive activities of Hydroflumethiazide.
Tianeptine Tianeptine may decrease the antihypertensive activities of Hydroflumethiazide.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Hydroflumethiazide.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Hydroflumethiazide.
Dihydroergocornine Dihydroergocornine may decrease the antihypertensive activities of Hydroflumethiazide.

Target Protein

Solute carrier family 12 member 1 SLC12A1
Carbonic anhydrase 7 CA7
Carbonic anhydrase 9 CA9
Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1
Calcium-activated potassium channel subunit alpha-1 KCNMA1
Carbonic anhydrase 1 CA1
Carbonic anhydrase 2 CA2
Carbonic anhydrase 4 CA4
Carbonic anhydrase 12 CA12

Referensi & Sumber

Synthesis reference: U.S. Patent 3,254,076.
Artikel (PubMed)
  • PMID: 19901136
    Moser M, Feig PU: Fifty years of thiazide diuretic therapy for hypertension. Arch Intern Med. 2009 Nov 9;169(20):1851-6. doi: 10.1001/archinternmed.2009.342.

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • Saluron
    Tablet • 50 mg/1 • Oral • US • Approved
International Brands
  • Leodrine — Leo

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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