Signs of metyrosine overdosage include those central nervous system effects observed in some patients even at low dosages. At doses exceeding 2000 mg/day, some degree of sedation or feeling of fatigue may persist. Doses of 2000-4000 mg/day can result in anxiety or agitated depression, neuromuscular effects (including fine tremor of the hands, gross tremor of the trunk, tightening of the jaw with trismus), diarrhea, and decreased salivation with dry mouth. The acute toxicity of metyrosine was 442 mg/kg and 752 mg/kg in the female mouse and rat respectively.
An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed)
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Fluvoxamine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Fluvoxamine. |
| Citalopram | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Citalopram. |
| Fluoxetine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Fluoxetine. |
| Duloxetine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Duloxetine. |
| Trazodone | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Trazodone. |
| Paroxetine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Paroxetine. |
| Sertraline | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Sertraline. |
| Sibutramine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Sibutramine. |
| Nefazodone | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Nefazodone. |
| Escitalopram | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Escitalopram. |
| Zimelidine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Zimelidine. |
| Dapoxetine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Dapoxetine. |
| Milnacipran | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Seproxetine. |
| Indalpine | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Indalpine. |
| Ritanserin | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Ritanserin. |
| Alaproclate | The risk or severity of extrapyramidal symptoms can be increased when Metyrosine is combined with Alaproclate. |
| Alfuzosin | Alfuzosin may increase the hypotensive activities of Metyrosine. |
| Amifostine | Metyrosine may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Metyrosine. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Metyrosine. |
| Obinutuzumab | Metyrosine may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Metyrosine. |
| Rituximab | Metyrosine may increase the hypotensive activities of Rituximab. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Metyrosine. |
| Cyclosporine | Cyclosporine may decrease the antihypertensive activities of Metyrosine. |
| Phentermine | Phentermine may decrease the antihypertensive activities of Metyrosine. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Metyrosine. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Metyrosine. |
| Methylergometrine | Methylergometrine may decrease the antihypertensive activities of Metyrosine. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Metyrosine. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Metyrosine. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Metyrosine. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Metyrosine. |
| Atropine | Atropine may decrease the antihypertensive activities of Metyrosine. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Metyrosine. |
| Epinephrine | Epinephrine may decrease the antihypertensive activities of Metyrosine. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Metyrosine. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Metyrosine. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Metyrosine. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Metyrosine. |
| Dobutamine | Dobutamine may decrease the antihypertensive activities of Metyrosine. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Metyrosine. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Metyrosine. |
| Terbutaline | Terbutaline may decrease the antihypertensive activities of Metyrosine. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Metyrosine. |
| Quinidine | Quinidine may decrease the antihypertensive activities of Metyrosine. |
| Salmeterol | Salmeterol may decrease the antihypertensive activities of Metyrosine. |
| Formoterol | Formoterol may decrease the antihypertensive activities of Metyrosine. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Metyrosine. |
| Albuterol | Salbutamol may decrease the antihypertensive activities of Metyrosine. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Metyrosine. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Metyrosine. |
| Dutasteride | Dutasteride may decrease the antihypertensive activities of Metyrosine. |
| Propafenone | Propafenone may decrease the antihypertensive activities of Metyrosine. |
| Finasteride | Finasteride may decrease the antihypertensive activities of Metyrosine. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Metyrosine. |
| Arformoterol | Arformoterol may decrease the antihypertensive activities of Metyrosine. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Metyrosine. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Metyrosine. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Metyrosine. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Metyrosine. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Metyrosine. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Metyrosine. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Metyrosine. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Metyrosine. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Metyrosine. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Metyrosine. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Metyrosine. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Metyrosine. |
| Solifenacin | Solifenacin may decrease the antihypertensive activities of Metyrosine. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Metyrosine. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Metyrosine. |
| Dronedarone | Dronedarone may decrease the antihypertensive activities of Metyrosine. |
| Indacaterol | Indacaterol may decrease the antihypertensive activities of Metyrosine. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Metyrosine. |
| Nylidrin | Nylidrin may decrease the antihypertensive activities of Metyrosine. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Metyrosine. |
| Droxidopa | Droxidopa may decrease the antihypertensive activities of Metyrosine. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Metyrosine. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Metyrosine. |
| Levonordefrin | Levonordefrin may decrease the antihypertensive activities of Metyrosine. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Metyrosine. |
| Saralasin | Saralasin may decrease the antihypertensive activities of Metyrosine. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Metyrosine. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Metyrosine. |
| Mirabegron | Mirabegron may decrease the antihypertensive activities of Metyrosine. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Metyrosine. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Metyrosine. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Metyrosine. |
| Olodaterol | Olodaterol may decrease the antihypertensive activities of Metyrosine. |
| Vilanterol | Vilanterol may decrease the antihypertensive activities of Metyrosine. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Metyrosine. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Metyrosine. |
| Moxisylyte | Moxisylyte may decrease the antihypertensive activities of Metyrosine. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Metyrosine. |
| Racepinephrine | Racepinephrine may decrease the antihypertensive activities of Metyrosine. |
| Dihydroergocornine | Dihydroergocornine may decrease the antihypertensive activities of Metyrosine. |
| DL-Methylephedrine | DL-Methylephedrine may decrease the antihypertensive activities of Metyrosine. |