Peringatan Keamanan

The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired, of if potassium is administered too rapidly intravenously, potentially fatal hyperkalemia can result. It is important to recognize that hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5-8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-wave, depression of S-T segment, and prolongation of the QT interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9-12 mEq/L).

Potassium chloride

DB00761

small molecule approved withdrawn

Deskripsi

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.

The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium per dosage unit, except for controlled-release dosage forms and those products formulated for preparation of solution prior to ingestion.L43942

Struktur Molekul 2D

Berat 74.551
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Potassium is a normal dietary constituent and under steady-state conditions the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Potassium is a normal dietary constituent and, under steady-state conditions, the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. Potassium depletion will occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake.

Interaksi Makanan

2 Data
  • 1. Take with a full glass of water.
  • 2. Take with food. This reduces gastrointestinal irritation.

Interaksi Obat

949 Data
Tramadol The risk or severity of gastrointestinal ulceration can be increased when Tramadol is combined with Potassium chloride.
Trospium The risk or severity of gastrointestinal ulceration can be increased when Trospium is combined with Potassium chloride.
Benzatropine The risk or severity of gastrointestinal ulceration can be increased when Benzatropine is combined with Potassium chloride.
Ziprasidone The risk or severity of gastrointestinal ulceration can be increased when Ziprasidone is combined with Potassium chloride.
Disopyramide The risk or severity of gastrointestinal ulceration can be increased when Disopyramide is combined with Potassium chloride.
Amitriptyline The risk or severity of gastrointestinal ulceration can be increased when Amitriptyline is combined with Potassium chloride.
Ipratropium The risk or severity of gastrointestinal ulceration can be increased when Ipratropium is combined with Potassium chloride.
Olanzapine The risk or severity of gastrointestinal ulceration can be increased when Olanzapine is combined with Potassium chloride.
Metixene The risk or severity of gastrointestinal ulceration can be increased when Metixene is combined with Potassium chloride.
Terfenadine The risk or severity of gastrointestinal ulceration can be increased when Terfenadine is combined with Potassium chloride.
Buclizine The risk or severity of gastrointestinal ulceration can be increased when Buclizine is combined with Potassium chloride.
Clozapine The risk or severity of gastrointestinal ulceration can be increased when Clozapine is combined with Potassium chloride.
Doxylamine The risk or severity of gastrointestinal ulceration can be increased when Doxylamine is combined with Potassium chloride.
Trihexyphenidyl The risk or severity of gastrointestinal ulceration can be increased when Trihexyphenidyl is combined with Potassium chloride.
Procyclidine The risk or severity of gastrointestinal ulceration can be increased when Procyclidine is combined with Potassium chloride.
Profenamine The risk or severity of gastrointestinal ulceration can be increased when Profenamine is combined with Potassium chloride.
Promazine The risk or severity of gastrointestinal ulceration can be increased when Promazine is combined with Potassium chloride.
Hyoscyamine The risk or severity of gastrointestinal ulceration can be increased when Hyoscyamine is combined with Potassium chloride.
Cyproheptadine The risk or severity of gastrointestinal ulceration can be increased when Cyproheptadine is combined with Potassium chloride.
Imipramine The risk or severity of gastrointestinal ulceration can be increased when Imipramine is combined with Potassium chloride.
Methscopolamine bromide The risk or severity of gastrointestinal ulceration can be increased when Methscopolamine bromide is combined with Potassium chloride.
Chlorpromazine The risk or severity of gastrointestinal ulceration can be increased when Chlorpromazine is combined with Potassium chloride.
Gallamine triethiodide The risk or severity of gastrointestinal ulceration can be increased when Gallamine triethiodide is combined with Potassium chloride.
Darifenacin The risk or severity of gastrointestinal ulceration can be increased when Darifenacin is combined with Potassium chloride.
Triflupromazine The risk or severity of gastrointestinal ulceration can be increased when Triflupromazine is combined with Potassium chloride.
Anisotropine methylbromide The risk or severity of gastrointestinal ulceration can be increased when Anisotropine methylbromide is combined with Potassium chloride.
Nortriptyline The risk or severity of gastrointestinal ulceration can be increased when Nortriptyline is combined with Potassium chloride.
Amoxapine The risk or severity of gastrointestinal ulceration can be increased when Amoxapine is combined with Potassium chloride.
Lamotrigine Potassium chloride may increase the hyperkalemic activities of Lamotrigine.
Atropine The risk or severity of gastrointestinal ulceration can be increased when Atropine is combined with Potassium chloride.
Nicardipine The risk or severity of gastrointestinal ulceration can be increased when Nicardipine is combined with Potassium chloride.
Pirenzepine The risk or severity of gastrointestinal ulceration can be increased when Pirenzepine is combined with Potassium chloride.
Paroxetine The risk or severity of gastrointestinal ulceration can be increased when Paroxetine is combined with Potassium chloride.
Homatropine methylbromide The risk or severity of gastrointestinal ulceration can be increased when Homatropine methylbromide is combined with Potassium chloride.
Rocuronium The risk or severity of gastrointestinal ulceration can be increased when Rocuronium is combined with Potassium chloride.
Scopolamine The risk or severity of gastrointestinal ulceration can be increased when Scopolamine is combined with Potassium chloride.
Benzquinamide The risk or severity of gastrointestinal ulceration can be increased when Benzquinamide is combined with Potassium chloride.
Clidinium The risk or severity of gastrointestinal ulceration can be increased when Clidinium is combined with Potassium chloride.
Propiomazine The risk or severity of gastrointestinal ulceration can be increased when Propiomazine is combined with Potassium chloride.
Biperiden The risk or severity of gastrointestinal ulceration can be increased when Biperiden is combined with Potassium chloride.
Brompheniramine The risk or severity of gastrointestinal ulceration can be increased when Brompheniramine is combined with Potassium chloride.
Flupentixol The risk or severity of gastrointestinal ulceration can be increased when Flupentixol is combined with Potassium chloride.
Cocaine The risk or severity of gastrointestinal ulceration can be increased when Cocaine is combined with Potassium chloride.
Quinidine The risk or severity of gastrointestinal ulceration can be increased when Quinidine is combined with Potassium chloride.
Maprotiline The risk or severity of gastrointestinal ulceration can be increased when Maprotiline is combined with Potassium chloride.
Cycrimine The risk or severity of gastrointestinal ulceration can be increased when Cycrimine is combined with Potassium chloride.
Tolterodine The risk or severity of gastrointestinal ulceration can be increased when Tolterodine is combined with Potassium chloride.
Oxybutynin The risk or severity of gastrointestinal ulceration can be increased when Oxybutynin is combined with Potassium chloride.
Promethazine The risk or severity of gastrointestinal ulceration can be increased when Promethazine is combined with Potassium chloride.
Diphenhydramine The risk or severity of gastrointestinal ulceration can be increased when Diphenhydramine is combined with Potassium chloride.
Doxacurium The risk or severity of gastrointestinal ulceration can be increased when Doxacurium is combined with Potassium chloride.
Doxepin The risk or severity of gastrointestinal ulceration can be increased when Doxepin is combined with Potassium chloride.
Flavoxate The risk or severity of gastrointestinal ulceration can be increased when Flavoxate is combined with Potassium chloride.
Desipramine The risk or severity of gastrointestinal ulceration can be increased when Desipramine is combined with Potassium chloride.
Orphenadrine The risk or severity of gastrointestinal ulceration can be increased when Orphenadrine is combined with Potassium chloride.
Escitalopram The risk or severity of gastrointestinal ulceration can be increased when Escitalopram is combined with Potassium chloride.
Quetiapine The risk or severity of gastrointestinal ulceration can be increased when Quetiapine is combined with Potassium chloride.
Mivacurium The risk or severity of gastrointestinal ulceration can be increased when Mivacurium is combined with Potassium chloride.
Diphenidol The risk or severity of gastrointestinal ulceration can be increased when Diphenidol is combined with Potassium chloride.
Aripiprazole The risk or severity of gastrointestinal ulceration can be increased when Aripiprazole is combined with Potassium chloride.
Chlorprothixene The risk or severity of gastrointestinal ulceration can be increased when Chlorprothixene is combined with Potassium chloride.
Metocurine The risk or severity of gastrointestinal ulceration can be increased when Metocurine is combined with Potassium chloride.
Pancuronium The risk or severity of gastrointestinal ulceration can be increased when Pancuronium is combined with Potassium chloride.
Pipecuronium The risk or severity of gastrointestinal ulceration can be increased when Pipecuronium is combined with Potassium chloride.
Methotrimeprazine The risk or severity of gastrointestinal ulceration can be increased when Methotrimeprazine is combined with Potassium chloride.
Tiotropium The risk or severity of gastrointestinal ulceration can be increased when Tiotropium is combined with Potassium chloride.
Solifenacin The risk or severity of gastrointestinal ulceration can be increased when Solifenacin is combined with Potassium chloride.
Rapacuronium The risk or severity of gastrointestinal ulceration can be increased when Rapacuronium is combined with Potassium chloride.
Pizotifen The risk or severity of gastrointestinal ulceration can be increased when Pizotifen is combined with Potassium chloride.
Fesoterodine The risk or severity of gastrointestinal ulceration can be increased when Fesoterodine is combined with Potassium chloride.
Dimetindene The risk or severity of gastrointestinal ulceration can be increased when Dimetindene is combined with Potassium chloride.
Aclidinium The risk or severity of gastrointestinal ulceration can be increased when Aclidinium is combined with Potassium chloride.
Dexetimide The risk or severity of gastrointestinal ulceration can be increased when Dexetimide is combined with Potassium chloride.
Benactyzine The risk or severity of gastrointestinal ulceration can be increased when Benactyzine is combined with Potassium chloride.
Umeclidinium The risk or severity of gastrointestinal ulceration can be increased when Umeclidinium is combined with Potassium chloride.
Dosulepin The risk or severity of gastrointestinal ulceration can be increased when Dosulepin is combined with Potassium chloride.
Imidafenacin The risk or severity of gastrointestinal ulceration can be increased when Imidafenacin is combined with Potassium chloride.
Butylscopolamine The risk or severity of gastrointestinal ulceration can be increased when Butylscopolamine is combined with Potassium chloride.
Thonzylamine The risk or severity of gastrointestinal ulceration can be increased when Thonzylamine is combined with Potassium chloride.
Revefenacin The risk or severity of gastrointestinal ulceration can be increased when Revefenacin is combined with Potassium chloride.
Propiverine The risk or severity of gastrointestinal ulceration can be increased when Propiverine is combined with Potassium chloride.
Batefenterol The risk or severity of gastrointestinal ulceration can be increased when Batefenterol is combined with Potassium chloride.
Tropatepine The risk or severity of gastrointestinal ulceration can be increased when Tropatepine is combined with Potassium chloride.
Phenglutarimide The risk or severity of gastrointestinal ulceration can be increased when Phenglutarimide is combined with Potassium chloride.
Etybenzatropine The risk or severity of gastrointestinal ulceration can be increased when Etybenzatropine is combined with Potassium chloride.
Emepronium The risk or severity of gastrointestinal ulceration can be increased when Emepronium is combined with Potassium chloride.
Bornaprine The risk or severity of gastrointestinal ulceration can be increased when Bornaprine is combined with Potassium chloride.
Etanautine The risk or severity of gastrointestinal ulceration can be increased when Etanautine is combined with Potassium chloride.
Chlorphenoxamine The risk or severity of gastrointestinal ulceration can be increased when Chlorphenoxamine is combined with Potassium chloride.
Glycopyrronium The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Potassium chloride.
Ramipril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Ramipril.
Fosinopril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Fosinopril.
Trandolapril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Trandolapril.
Benazepril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Benazepril.
Enalapril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Enalapril.
Moexipril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Moexipril.
Lisinopril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Lisinopril.
Perindopril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Perindopril.
Quinapril The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Quinapril.
Omapatrilat The risk or severity of hyperkalemia can be increased when Potassium chloride is combined with Omapatrilat.

Target Protein

Solute carrier family 12 member 2 SLC12A2
Solute carrier family 12 member 1 SLC12A1
Solute carrier family 12 member 5 SLC12A5
Solute carrier family 12 member 6 SLC12A6
Solute carrier family 12 member 7 SLC12A7
Solute carrier family 12 member 4 SLC12A4

Referensi & Sumber

Synthesis reference: Fritz Hagedorn, Gerd Peuschel, Arno Singewald, "Method for the production of potassium chloride with K.sub.2 O content of more than 55 weight percent." U.S. Patent US5057208, issued July, 1955.

Contoh Produk & Brand

Produk: 1588 • International brands: 5
Produk
  • (20 Mmol/l) Potassium Chloride In 3.3% Dextrose and 0.3% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20 Mmol/l) Potassium Chloride In 5% Dextrose and 0.9% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20 Mmol/l) Potassium Chloride In 5% Dextrose Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 5% Dextrose and 0.2% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (20mmol/l) Potassium Chloride In 5% Dextrose and 0.45% Sodium Chloride Injection USP
    Solution • - • Intravenous • Canada • Approved
  • (40 Mmol/l) Potassium Chloride In 0.9% Sodium Chloride Injection USP
    Liquid • - • Intravenous • Canada • Approved
  • (40 Mmol/l) Potassium Chloride In 5% Dextrose Injection USP
    Solution • - • Intravenous • Canada • Approved
Menampilkan 8 dari 1588 produk.
International Brands
  • Kaon Cl
  • Kaon-CL 10
  • Micro-K
  • Sando-K
  • Slow-K

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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