In mice and rats, large intravenous doses of meropenem (2200-4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI). Vabomere consists of meropenem and DB12107 and is intravenously admininstered. The treatment aims to resolve infection-related symptoms and achieve negative urine culture, where the infections are proven or strongly suspected to be caused by susceptible bacteria.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Probenecid | The excretion of Meropenem can be decreased when combined with Probenecid. |
| Valproic acid | The serum concentration of Valproic acid can be decreased when it is combined with Meropenem. |
| BCG vaccine | The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Meropenem. |
| Typhoid vaccine | The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Meropenem. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Meloxicam | The risk or severity of methemoglobinemia can be increased when Meropenem is combined with Meloxicam. |
| Carprofen | Carprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Lopinavir | Lopinavir may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Etoricoxib | Etoricoxib may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Cephalothin Group | Cephalothin Group may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Latamoxef | Latamoxef may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Nimesulide | Nimesulide may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Zomepirac | Zomepirac may decrease the excretion rate of Meropenem which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Meropenem which could result in a higher serum level. |